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| 1 | Matrix metalloproteinase gene expressions might be oxidative stress targets in gastric cancer cell lines显示文摘Objective: Oxidative stress is linked to increased risk of gastric cancer and matrix metalloproteinases (MMPs) are important in the invasion and metastasis of gastric cancer. We aimed to analyze the effect of the accumulation of oxidative stress in the gastric cancer MKN-45 and 23132/87 cells following hydrogen peroxide (H 2 O 2 ) exposure on the expression patterns of MMP-1, MMP-3, MMP-7, MMP-9, MMP-10, MMP- 11, MMP-12, MMP-14, MMP-15, MMP-17, MMP-23, MMP-28, and β-catenin genes. Methods: The mRNA transcripts in the cells were determined by RT-PCR. Following H 2 O 2 exposure, oxidative stress in the viable cells was analyzed by 2',7'-dichlorofluorescein diacetate (DCFH-DA). Caffeic acid phenethyl ester (CAPE) was used to eliminate oxidative stress and the consequence of H 2 O 2 exposure and its removal on the expressions of the genes were evaluated by quantitative real-time PCR. Results: The expressions of MMP-1, MMP-7, MMP-14, MMP-15, MMP-17 and β-catenin in MKN-45 cells and only the expression of MMP-15 in 23132/87 cells were increased. Removal of the oxidative stress resulted in decrease in the expressions of MMP genes of which the expressions were increased after H 2 O 2 exposure. β-catenin, a transcription factor for many genes including MMPs, also displayed decreased levels of expression in both of the cell lines following CAPE treatment. Conclusions: Our data suggest that there is a remarkable link between the accumulation of oxidative stress and the increased expressions of MMP genes in the gastric cancer cells and MMPs should be considered as potential targets of therapy in gastric cancers due to its continuous exposure to oxidative stress. | Salih Gencer Anil Cebeci Meliha Burcu Irmak-Yazicioglu | 2013 | Chinese Journal of Cancer Research2013，25，3： | 13 |
| 2 | Skin disorders in peritoneal dialysis patients:An underdiagnosed subject显示文摘AIM: To examine all skin changes in peritoneal dialysis(PD) patients followed up in our unit.METHODS: Patients on PD program for at least three months without any known chronic skin disease were included in the study. Patients with already diagnosed skin disease, those who have systemic diseases that may cause skin lesions, patients with malignancies and those who did not give informed consent were excluded from the study. All patients were examined by the same predetermined dermatologist with all findings recorded. The demographic, clinical and laboratory data including measures of dialysis adequacy of patients were recorded also. Statistical Package for Social Sciences(SPSS) for Windows 16.0 standard version was used for statistical analysis.RESULTS: Among the patients followed up in our PD unit, those without exclusion criteria who gave informed consent, 38 patients were included in the study with male/female ratio and mean age of 26/12 and 50.3 ± 13.7 years, respectively. The duration of CKD was 7.86 ± 4.16 years and the mean PD duration was 47.1 ± 29.6 mo. Primary kidney disease was diabetic nephropathy in 11, nephrosclerosis in six, uropathologies in four, chronic glomerulonephritis in three, chronic pyelonephritis in three, autosomal dominant polycystic kidney disease in three patients while cause was unknown in eight patients. All patients except for one patient had at least one skin lesion. Loss of lunula, onychomycosis and tinea pedis are the most frequent skin disorders recorded in the study group. Diabetic patients had tinea pedis more frequently(P = 0.045). No relationship of skin findings was detected with primary renal diseases, comorbidities and medications that the patients were using.CONCLUSION: Skin abnormalities are common in in PD patients. The most frequent skin pathologies are onychomycosis and tinea pedis which must not be overlooked. | Meltem Gursu Sami Uzun Derya Topcuoglu Leyli Kadriye Koc Lamiye Yucel Abdullah Sumnu Egemen Cebeci Oktay Ozkan Ahmet Behlul Leyla Koc Savas Ozturk Rumeyza Kazancioglu | 2016 | World Journal of Nephrology2016，5，4： | 3 |
| 3 | A study on the relationship between critical surface tension of wetting and oil agglomeration recovery of calcite显示文摘 | Yakup Cebeci Ibrahim Snmez | 2004 | Journal of Colloid and Interface Science2004，273，： | 1 |
| 4 | Aircraft icing显示文摘 | Cebeci T Kafyeke F | 2003 | Annu Rev Fluid Mech2003，35，： | 1 |
| 5 | Nanoporosity-driven superhydrophilicity: a means to create multifunctional antifogging coatings显示文摘 | CEBECI FC WU Z ZHAI L | 2006 | Langmuir2006，22，6： | 1 |
| 6 | Life experienees of women with breast cancer in Soutll Western Turkey: a qualitative stucly显示文摘 | Cebeci F Yangin HB Tekeli A | 2012 | Europcan Journal of Oncology Nursing2012，16，4： | 1 |
| 7 | Investigation of pollution flashover on high voltage insulators using artificial neural network显示文摘 | GENOLU M T CEBECI M | 2009 | Expert Systems with Applications2009，36，4： | 1 |
| 8 | Silencing of the MMP-3 gene by siRNA transfection in gastric cancer AGS cells 显示文摘 | Gencer S Cebeci A Rada JA | 2011 | J Gastrointestin Liver Dis2011，，1： | 1 |
| 9 | Nanoporosity-driven su- perhydrophilicity:a means to create multifunctional anti- fogging coatings显示文摘 | Cebeci F C Wu Z Zhai L | 2006 | Langmuir2006，22，： | 1 |
| 10 | The investigation of the floatability improvement of Yozgat Ayridam lignite using various collectors显示文摘 | Cebeci Y | | 0，，03： | 1 |
| 11 | On stability and transition in three dimensional flos 显示文摘 | | | AIAA Journal0，18，： | 1 |
| 12 | Prognostic significance of ischemia-modified albumin in patients with acute coronary syndrome显示文摘 | Mustafa Aparci Ejder Kardesoglu Namk Ozmen ?mer Ozcan Bekir Stk Cebeci Bekr Ylmaz Cingozbay Mehmet Dincturk | 2007 | Coronary Artery Disease2007，，5： | 1 |
| 13 | Multi-attribute com- parison of catering service companies using fuzzy AHP:the case of Turkey 显示文摘 | Kahraman C Cebeci U Ruan D | 2004 | International Journal of Production Economics2004，87，2： | 1 |
| 14 | The investigation of the floatability improvement of YozgatAyridam lignite using various collectors 显示文摘 | CEBECI Y | 2002 | Fuel2002，81，3： | 1 |
| 15 | Prenatal diagnosis of 13q- syndrome in a fetus with Dandy-Walker malformation 显示文摘 | Gul A Cebeci A Erol O | 2005 | Obstet Gyneco12005，105，： | 1 |
| 16 | Prevalence and distribution of oral mucosal lesions in an adult Turkish population显示文摘 | Cebeci AR Gülsahi A Kamburoglu K | 2009 | Med Oral Patol Oral Cir Bucal2009，14，： | 1 |
| 17 | Multi - criteria supplier selection using fuzzy- AHP显示文摘 | Kahraman C Cebeci U Ulukan Z | 2003 | Logistics Information Management2003，16，6： | 1 |
| 18 | Fuzzy AHP-based decision support system for selecting ERP systems in textile industry by using balanced scorecard 显示文摘 | Cebeci U | 2009 | Expert Systems with Applica- tions2009，36，5： | 1 |
| 19 | Comparison of sucrose, expressed breast milk,and breast-feeding on the neonatal responses to heel prick显示文摘 | Bilgen H Ozek E Cebeci D | 2001 | J Pain2001，2，5： | 1 |
| 20 | Association between chronic urticaria and thyroid autoimmunity显示文摘 | Cebeci F Tanrikut A Topcu E | 2006 | Eur J Dermatol2006，16，4： | 1 |
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