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| 1 | Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know显示文摘Granulocyte 巨噬细胞刺激殖民地的因素(GM-CSF ) 是一个重要造血的生长因素和有免疫力的调节的人。GM-CSF 也在各种各样的传播白血球的功能的活动有深刻效果。它被许多房间类型在收到有免疫力的刺激之上包括 T 房间,巨噬细胞, endothelial 房间和成纤维细胞生产。尽管 GM-CSF 局部地被生产,它能以一种 paracrine 方式行动到在主人防卫提高他们的功能的成员传播 neutrophils,单核白血球和淋巴细胞。最近的集中的调查为它增加树枝状的房间(DC ) 成熟和功能以及巨噬细胞活动的能力作为一个有免疫力的助手在 GM-CSF 的应用程序上被集中。在经历化疗的癌症病人对待嗜中性白血球减少症临床上被使用,在在治疗期间的爱滋病病人,并且在在骨髓移植以后的病人。有趣地, GM-CSF-deficient 老鼠的造血的系统看起来正常;最重要的变化在一些特定的 T 房间回答。尽管 GM-CSF 的分子的克隆用 T 房间的 cDNA 图书馆被执行, T 房间在激活以后生产 GM-CSF,是众所周知的,在 T 房间功能上有在由 T 房间和它的效果的生产的这 cytokine 的系统的调查的缺乏。在这篇文章,我们将在 T 房间主要集中于 GM-CSF 的免疫生物学。 | Yufang Shi Catherine H Liu Arthur I Roberts Jyoti Das Guangwu Xu Guangwen Ren Yingyu Zhang Liying Zhang Zeng Rong Yuan Hung Sheng William Tan Gobardhan Das Satish Devadas | 2006 | Cell Research2006，16，2： | 22 |
| 2 | Quasispecies evolution in NS5A region of hepatitis C virus genotype 1b during interferon or combined interferon-ribavirin therapy显示文摘AIM: To evaluate the implication of substitutions in the hepatitis C virus (HCV) non-structural 5A (NS5A) protein in the resistance of HCV during mono-interferon (IFN) or combined IFN-ribavirin (IFN-R) therapy. Although NS5A has been reported to interact with the HCV RNA- dependent RNA polymerase, NS5B, as well as with many cellular proteins, the function of NS5A in the life cycle of HCV remains unclear. METHODS: HCV quasispecies were studied by clon- ing and sequencing of sequential isolates from patients infected by HCV genotype 1b. Patients were treated by IFN-α2b for 3 mo followed by IFN-α2b alone or com- bined IFN-R therapy for 9 additional months. Patients were categorized intro two groups based on their re- sponse to the treatments: 7 with sustained virological re- sponse (SVR) (quasispecies = 150) and 3 non-respond- ers (NR) to IFN-R (quasispecies = 106). RESULTS: Prior to treatment, SVR patients displayed a lower complexity of quasispecies than NR patients. Most patients had a decrease in the complexity of quasispe- cies during therapy. Analysis of amino acids substitu- tions showed that the degree of the complexity of the interferon sensitivity-determining region (ISDR) and the V3 domain of NS5A protein was able to discriminate thetwo groups of patients. Moreover, SVR patients displayed more variability in the NS5A region than NR patients. CONCLUSION: These results suggest that detailed mo- lecular analysis of the NS5A region may be important for understanding its function in IFN response during HCV 1b infection. | Pascal Veillon Christopher Payan Hélène Le Guillou-Guillemette Catherine Gaudy Franoise Lunel | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 3 | Animal models for the study of hepatitis C virus infection and replication显示文摘Hepatitis C virus (HCV) hepatitis, initially termed non-A, non-B hepatitis, has become one of the leading causes of cirrhosis and hepatocellular carcinoma worldwide. With the help of animal models, our understanding of the virus has grown substantially from the time of initial discovery. There is a paucity of available animal models for the study of HCV, mainly because of the selective susceptibility limited to humans and primates. Recent work has focused modification of animals to permit HCV entry, replication and transmission. In this review, we highlight the currently available models for the study of HCV including chimpanzees, tupaia, mouse and rat models. Discussion will include methods of model design as well as the advantages and disadvantages of each model. Particular focus is dedicated to knowledge of pathophysiologic mechanisms of HCV infection that have been elucidated through animal studies. Research within animal models is critically important to establish a complete understanding of HCV infection, which will ultimately form the basis for future treatments and prevention of disease. | Kristin L MacArthur Catherine H Wu George Y Wu | 2012 | World Journal of Gastroenterology2012，18，23： | 6 |
| 4 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 5 | Inhibition of hepatitis C virus replication by single-stranded RNA structural mimics显示文摘AIM: To examine the effect of hepatitis C virus (HCV) structural mimics of regulatory regions of the genome on HCV replication.METHODS: HCV RNA structural mimics were constructed and tested in a HCV genotype 1b aBB7 replicon,and a Japanese fulminant hepatitis-1 (JFH-1) HCV genotype 2a infection model.All sequences were computer-predicted to adopt stem-loop structures identical to the corresponding elements in full-length viral RNA.Huh7.5 cells bearing the BB7 replicon or infected with JFH-1 virus were transfected with expression vectors generating HCV mimics and controls.Cellular HCV RNA and protein levels were quantified by real-time polymerase chain reaction and Western blotting,respectively.To evaluate possible antisense effects,complementary RNAs spanning a mimic were prepared.RESULTS: In the BB7 genotype 1b replicon system,mimics of the polymerase (NS-5B),X and BA regions inhibited replication by more than 90%,50%,and 60%,respectively.In the JFH-1 genotype 2 infection system,mimics that were only 74% and 46% identical in sequence relative to the corresponding region in JFH-1 inhibited HCV replication by 91.5% and 91.2%,respectively,as effectively as a mimic with complete identity to HCV genotype 2a.The inhibitory effects were confirmed by NS3 protein levels.Antisense RNA molecules spanning the 74% identical mimic had no significant effects.CONCLUSION: HCV RNA structural mimics can inhibit HCV RNA replication in replicon and infectious HCV systems and do so independent of close sequence identity with the target. | Robert Smolic Martina Smolic John H Andorfer Catherine H Wu Robert M Smith George Y Wu | 2010 | World Journal of Gastroenterology2010，16，17： | 2 |
| 6 | Effect of Cyclosporine on Left Ventricular Remodeling After Reperfused Myocardial Infarction显示文摘 | Nathan Mewton Pierre Croisille Gerald Gahide Gilles Rioufol Eric Bonnefoy Ingrid Sanchez Thien Tri Cung Catherine Sportouch Denis Angoulvant Gérard Finet Xavier André-Fou?t Geneviève Derumeaux Christophe Piot Hélène Vernhet Didier Revel Michel Ovize | 2010 | Journal of the American College of Cardiology2010，，12： | 2 |
| 7 | 肝纤维化显示文摘 | 陆伦根 Catherine H Wu George Y Wu | 2000 | 胃肠病学2000，5，2： | 2 |
| 8 | Hepatitis C and renal disease: an update 1 1 Summary of a workshop held October 21 to 22, 2002, in the Lister Hill Auditorium, The National Institutes of Health, Bethesda, MD.显示文摘 | Catherine M Meyers Leonard B Seeff Catherine O Stehman-Breen Jay H Hoofnagle | 2003 | American Journal of Kidney Diseases2003，，4： | 2 |
| 9 | Rheological behavior of water-in-oil emulsions stabilized by hydrophobic bentonite particles显示文摘 | Bernard P Binks John H Chnt Catherine P Whitby | 2005 | Langmuir2005，21，21： | 1 |
| 10 | Neoadjuvant Chemotherapy plus Cystectomy Compared with Cystectomy Alone for Locally Advanced Bladder Cancer显示文摘 | H BARTON GROSSMAN RONALD B NATALE CATHERINE M | 2003 | N Engl J Med2003，349，： | 1 |
| 11 | High throughput sequencing reveals a complex pattern of dynamic interrelationships among human Tcell subsets显示文摘 | Wang C Catherine M Jian H | 2010 | Prec Nail Acad Sei U S A2010，107，4： | 1 |
| 12 | New chiral olgopyridines- 4,4 ~ - his ( disaccharide)-functionalized 2,2 ' - bipyridines and 4 ' - (disaccharide) functionalized 2,2 ' : 6 ', 2' terpyridines 显示文摘 | Edwin C C Catherine E H Azad M | 2008 | Carbohydrate Research2008，343，： | 1 |
| 13 | Methylenetetrahydrofolate reductase 677C→T genotype modulates homocysteine responses to a folate-rich diet or a low-dose folic acid supplement: a randomized controlled trial 显示文摘 | Pauline A L Ashfield-Watt Catherine H Pullin | 2002 | Am J Clin Nutr2002，76，1： | 1 |
| 14 | Molecular analysis of sorghum resistance to greenbug(Homoptera:Aphididae) 显示文摘 | CATHERINE S KATSAR ANDREW H | 1999 | Journal of Economic Entomology1999，4，7： | 1 |
| 15 | The Activity and Mechanism of Uranium Oxide Catalysts for the Oxidative Destruction of Volatile Organic Compounds显示文摘 | CATHERINE S H GRAHAM J H | 2000 | Catalysis Today2000，59，： | 1 |
| 16 | Glutamate dehy--drogenase activity: a major criterion for the selection of flavour-produc-ing lactic acid bacteria strains显示文摘 | CATHERINE T AGNIESZKA K SANDRA H | 2002 | Antonie Van Leeuwenhoek2002，82，4： | 1 |
| 17 | Ethanol production in China: potential and technologies 显示文摘 | Li S Z Catherine C H | 2009 | Applied Energy2009，，： | 1 |
| 18 | Thymoma: trends over time显示文摘 | Katrina H Moore Paul R McKenzie Catherine W Kennedy Brian C McCaughan | 2001 | The Annals of Thoracic Surgery2001，，1： | 1 |
| 19 | Inverse association between the effect of carbohydrates on blood glucose and subsequent short term food intake in young men 显示文摘 | Anderson G H Catherine N L Woodend D M | 2002 | American Journal of Clinical Nutrition2002，76，5： | 1 |
| 20 | Single risk fact or interventions to promote physical activity among patients with chronic disease显示文摘 | Catherine H Martin F Hassan S | 2008 | Cana Fami Physiei2008，54，8： | 1 |
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