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| 1 | Liver Nuclear Activation of Carbon Tetrachloride or Bromotrichloromethane to Trichloromethyl and Trichloromethylperoxyl Free Radicals.Their Reactions With Lipids and Proteins显示文摘The formation of·CCl3 radicals in liver nuclei was suggested by spin trapping of them with N-t-butyl-α-phenylnitrone followed by GC/MS detection of the resulting adduct. Comparison of its formation in microsomal biotransformation of CCl4 was made. In aerobic nuclear activation mixtures containing NADPH and CCl4, significant decrease in the arachidonic acid content of nuclear lipids was observed (27. 8%, compared to control), the intensity of this decrease was lower than that occurring in the corresponding microsomal incubation mixtures (29.1%). Significant decreases in arachidonic acid content of nuclear and endoplasmic reticulum lipids were also observed in animals at 6 hours of poisoning with the haloalkane. During aerobic nuclear metabolism of CCl4 or CBrCl3, cholesterol oxidation products were detected: a ketocholesterol, an epoxide like structure and 7-ketocholesterol. Nuclear protein carbonyl formation was not promoted during nuclear CCl4 biotransformation. NADPH by itself may lead to protein carbonyl formation during prolonged periods of incubation. CBrCl3 in contrast, led to decreased protein carbonyl formation. No increase in nuclear protein carbonyl formation was observed in CCl4 intoxicated animals during periods of time between 1 to 6 hours after treatment. The results indicate that during nuclear biotransformation of CCl4 or CBrCl3 reactive free radicals, PUFA degradation, reactive aldehydes and cholesterol oxidation products are formed, nearby DNA and regulatory proteins. | S. L. FANELLI G. D. CASTRO M. E. GALELLI AND J. A. CASTRO (Centro de Investigaciones Toxicologicas(CEITOX)-CITEFA/CONICET, Zufriategui 4380, 1603 Villa Martelli,Buenos Aires, Argentina)(Send correspondence to Dr. Jose Alberto Castro, Zufriategui 4380, 1 | 1998 | Biomedical and Environmental Sciences1998，11，2： | 4 |
| 2 | Statistical analysis for improving data precision in the SPME GC-MS analysis of black berry (Rubus ulmifolius Schott) volatiles显示文摘 | D’Agostino M F Sanz J Castro Mart 1 nez | 2014 | Talanta2014，125，： | 1 |
| 3 | Genetic and epigenetic silencing of microRNA - 203 enhances ABLl and BCR - ABLl oncogene expression 显示文摘 | BUENO M 1 PEREZ DE CASTRO I G6MEZ DE CEDR6N M et aI | 2008 | Cancer Cell2008，13，6： | 1 |
| 4 | Interleukin-2 receptor signaling: at the interface between tolerance and immunity 显示文摘 | Malek TR Castro 1 | 2010 | Immunity2010，33，2： | 1 |
| 5 | Structural insight into the transglyeosylation step of bacterial cell-wall biosyn- thesis 显示文摘 | Lovering AI de Castro LH Lim 1) | 2007 | Scient e2007，315，： | 1 |
| 6 | Mechanisms of bee venom-induced acute renal failure显示文摘 | Crisotto Mendes CE Castro 1 | 2006 | Toxicon2006，48，1： | 1 |
| 7 | Microsurgical coil remov- al afier coiling a carotid t)ifurcation aneurysm 显示文摘 | Christoph DH Castro 1 Siqueira SB | 2010 | Arq Neurop- siquiatr2010，68，5： | 1 |
| 8 | Evaluation of an enzyme im- munoassay teehnipue for detection of antibodies Treponema palli-dum显示文摘 | Castro R Prieto ES Santo 1 | 2003 | J Clin Microbiol2003，41，1： | 1 |
| 9 | Occurrence of polychlorinated dibenzo - p - dioxins and dibenzofurans ( PCDD/Fs ), polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in Lake Maggiore (Italy and Switzerland) 显示文摘 | Vives 1 Canuti E Castro - Jimenez J | 2007 | J Environ Monit2007，9，6： | 1 |
| 10 | Anaerobic sludge granulation 显示文摘 | Hulshoff Pol L W de Castro Lopes S 1 Lettinga G | 2004 | Water Res2004，38，6： | 1 |
| 11 | Renal dysfunction potentiates foamcell fonnation l)y repressing ABCA1 显示文摘 | Zuo Y Yancey P Castro 1 | 2009 | Ailerioscler Thromb Vase Bi-ol2009，29，9： | 1 |
| 12 | Thermoeconomic analysis applied in cold water production system using biogas combustion 显示文摘 | Irai'des Aparecida de Castro Villela Jose' Luz Silveira 1 | 2005 | Applied Thermal Engineering2005，25，： | 1 |
| 13 | A theoretical study of abiotic methylation reactions of gaseous elemental mercury by halogen- containing molecules显示文摘 | Castro L Dommergue A 1 Larose C | 2011 | The Joumal of Physical Chemistry A2011，115，22： | 1 |
| 14 | Unsteady numerical simulation of the cooling process of vertical storage tanks under laminar natural convection显示文摘 | Rodriguez 1 CASTRO J P6rez-Segarra C D | 2009 | International Journal of Thermal Science2009，48，4： | 1 |
| 15 | Evaluation of the passive particle agglutination test in the serodiagnosis and follow-up of syphilis显示文摘 | Castro RR Prieto ES Santo 1 | 2001 | Am J Clin Patho12001，116，4： | 1 |
| 16 | Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease显示文摘 | Castro R Rivera 1 Struys EA | | 0，，08： | 1 |
| 17 | A census of mitotic cancer genes new insights into tumor cell biology and cancer therapy显示文摘 | P6rez de Castro 1 de Circer G Malumbres M | 2007 | Carcinogenesis2007，28，5： | 1 |
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