|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impact of asialoglycoprotein receptor deficiency on the development of liver injury显示文摘The asialoglycoprotein (ASGP) receptor is a wellcharacterized hepatic receptor that is recycled via the common cellular process of receptor-mediated endocytosis (RME). The RME process plays an integral part in the proper traff icking and routing of receptors and ligands in the healthy cell. Thus, the missorting or altered transport of proteins during RME is thought to play a role in several diseases associated with hepatocyte and liver dysfunction. Previously, we examined in detail alterations that occur in hepatocellular RME and associated receptor functions as a result of one particular liver injury, alcoholic liver disease (ALD). The studies revealed profound ethanolmediated impairments to the ASGP receptor and the RME process, indicating the importance of this receptor and the maintenance of proper endocytic events in normal tissue. To further clarify these observations, studies were performed utilizing knockout mice (lacking a functional ASGP receptor) to which were administered several liver toxicants. In addition to alcohol, we examined the effects following administration of antiFas (CD95) antibody, carbon tetrachloride (CCl4) and lipopolysaccharide (LPS)/galactosamine. The results of these studies demonstrated that the knockout mice sustained enhanced liver injury in response to all of the treatments, as shown by increased indices of liver damage, such as enhancement of serum enzyme levels, histopathological scores, as well as hepatocellular death. Overall, the work completed to date suggests a possible link between hepatic receptors and liver injury. In particular, adequate function and content of the ASGP receptor may provide protection against various toxinmediated liver diseases. | Serene ML Lee Carol A Casey Benita L McVicker | 2009 | World Journal of Gastroenterology2009，15，10： | 2 |
| 2 | Regulation of monocyte chemotactic protein-1 gene expression in human endometrial cells in cul-ture显示文摘 | Arici A MacDonald PC Casey ML | 1995 | Mol Cell Endocrinol1995，107，： | 1 |
| 3 | Modulation of the levels of transforming growth factor-b mRNA in human endometrial stromal cells显示文摘 | Arici A MacDonald PC Casey ML | 1996 | Biol Reprod1996，54，： | 1 |
| 4 | Endothelin-1 gene expression and biosynthesis in human endothmetrical HEC-1 A cancer cell显示文摘 | Economos K Macdondd PC Casey ML | | 0，，03： | 1 |
| 5 | Cachetin/tumor necrosis factor - α formation in human deciduas potential role of cytokine in fection induced preterm labour显示文摘 | Casey ML Cox SM Beuther B | 1989 | J Clin Invest1989，33，： | 1 |
| 6 | Formation of deoxycorticosterone from progesterone in extraadrenal tissues:demonstration of steroid 21-hydroxylase activity in human aorta显示文摘 | Casey ML Macdonald PC | 1982 | J Clin Endocrinol Metab1982，55，4： | 1 |
| 7 | Modulation of the levels of interleukin-8 messenger ribonucleic acid and intcrleukin-8 protein synthesis in human endometrial stromal cells by transforming growth factor-beta 1 显示文摘 | Arici A MacDonald PC Casey ML | 1996 | J Clin Endocrinol Mel:ab1996，81，： | 1 |
| 8 | Interstitial collagen synthesis and processing in human amnion : A property of the mesenchymal cells 显示文摘 | Casey ML MacDonald PC | 1996 | Biol Reprod1996，55，： | 1 |
| 9 | Phospholipid and neutral lipid separation by one-dimensional thin-layer chromatography 显示文摘 | Korte K Casey ML | 1982 | J Chromatography1982，232，1： | 1 |
| 10 | Interstitial collagen synthesis and processing in human amnion: a property of the mesenchymal cells显示文摘 | Casey ML MacDonald PC | 1996 | Biol Reprod1996，55，6： | 1 |
| 11 | Interstitial collagen synthesis and processing in human amnion:a property of the mesenchymal cells显示文摘 | Casey ML MacDonald PC | 1996 | Biol Reprod1996，55，6： | 1 |
| 12 | Characterization of catechol-O-methyltrans- ferase activity in human uterine decidua vera tissue显示文摘 | Casey ML MacDonald C | 1983 | Am J Obstet Gynecol1983，145，4： | 1 |
| 13 | White blood cell count can aid judicious antibiotic prescribing in acute upper respiratory infections in children 显示文摘 | Casey JR Marsocci SM Murphy ML | 2003 | Clin Pediatr (Phila)2003，42，： | 1 |
| 14 | Structure and developmental Expression of the Mouse CCK-B Receptor Gene显示文摘 | Jean ML Casey J Lennart FH | 2000 | Biochem Biophys Res Commun2000，272，： | 1 |
| 15 | Maintenance and characterization of human myometrial smooth muscle cell in monolayer culture显示文摘 | Casey ML MacDonald PC Mitchell MD | 1984 | In vitro1984，20，5： | 1 |
| 16 | Interstitial collagen synthesis and pro- cessing in human amnion:a property of the mesenchymal cells显示文摘 | Casey ML MacDonald PC | 1996 | Biol Reprod1996，55，6： | 1 |
| 17 | Extraadrenal formation of a mlneraloco- rticosteroid: deoxycorticosterone and deoxycorticosterone sulfate biosynthesis and metabolism 显示文摘 | Casey ML MacDonald PC | 1982 | Endocr Rev1982，3，4： | 1 |
| 18 | Maintenance and characterization of human myometrial smooth muscle cell in monolayer culture显示文摘 | Casey ML MacDonald PC Mitchell MD | 1984 | In vitro1984，20，5： | 1 |
| 19 | Extraadrenal formation of a mineralocorticosteroid:deoxycor-ticosterone and deoxycorticosterone sulfate biosynthesis and metabolism显示文摘 | Casey ML MacDonald PC | 1982 | Endocr Rev1982，3，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员