|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 2 | Analysis of peridural scar formation and its prevention after lumbar laminotomy and discectomy in dogs显示文摘 | SONGER M N RAUSCHNING W CARSON E W | 1995 | Spine1995，20，5： | 1 |
| 3 | Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinasdmTOR inhibitor显示文摘 | Van Aller G S Carson J D Tang W | 2011 | Biochem Biophys Res Cornmun2011，406，2： | 1 |
| 4 | Gasometric determination of nitrite and sulfamate显示文摘 | CARSON W N | 1951 | Analytical Chemistry1951，23，7： | 1 |
| 5 | Structural variation in the human genome显示文摘 | FEUK L CARSON A R Scherer S W | 2006 | Nat Rev Genet2006，7，2： | 1 |
| 6 | Drought stress and tropical for-est woody seedlings:Effect on community structure and composi-tion显示文摘 | BUNKER D E CARSON W P | 2005 | Journal of Ecology2005，93，4： | 1 |
| 7 | A modular spinal rod linkage system to provide rotational stability显示文摘 | Asher M Carson W Heinig C | 1988 | Spine1988，13，3： | 1 |
| 8 | A Faraday effect optical isolator显示文摘 | L J Aplet J W Carson | 1964 | Appl Opt1964，3，4： | 1 |
| 9 | 显示文摘 | Jolly M R Bender J W Carson J | 1998 | SPIE1998，3327，： | 1 |
| 10 | Results of aggressive treatment of gastric sarcoma显示文摘 | Carson W Karakousis C Douglass H | 1994 | Surg Oncol1994，1，： | 1 |
| 11 | Reversible mid- dle cerebral artery occlusion without cranieetomy in rats 显示文摘 | Longa E Z W einstein P R Carson S | 1989 | Stroke1989，20，1： | 1 |
| 12 | Bin loads-Part 2: concepts 显示文摘 | A W Jenike J R Johanson and J W Carson | 1973 | Journal of Engineering for Industry1973，，： | 1 |
| 13 | Voltage Stability Analysis:V-Q Power Flow Simulation versus Dynamic Simulation显示文摘 | Badrul H Chowdhury Carson W Taylor | 2001 | IEEE Transactions on Power SystemS2001，15，4： | 1 |
| 14 | The Importance of Storage, Transfer and Collection 显示文摘 | KNOWLTON T M CARSON J W KLINZING G E | 1994 | Chemical Engineering Progress1994，90，1： | 1 |
| 15 | Analysis of peridural scar formation and its prevention after lumbar:laminotomy and discectomy in dogs显示文摘 | Rauschning W Carson EW | 1995 | Spine1995，20，5： | 1 |
| 16 | The Effects of Positiveand Negative Online Customer Reviews : do Brand Strength andCategory Maturity Matter显示文摘 | Ho-Dac N N Carson S J Moore W L | 2013 | Journal of Marketing2013，77，6： | 1 |
| 17 | Atrial fibrillation in pregnancy associated with oral terbutaline显示文摘 | Carson M P Fisher A J Scorza W E | 2002 | Obstet Gynecol2002，100，5： | 1 |
| 18 | Development of an InternationalStandard for Shear Testing显示文摘 | CARSON J W HARALD W | 2006 | Powder Technology2006，167，： | 1 |
| 19 | Extended Antkumor Response of a BRAF V600E Papillary Thyroid Carcinoma to Vemurafenib显示文摘 | Ali SM He J Carson W | 2014 | Case Rep Oncol2014，7，： | 1 |
| 20 | Uptake and Excretion of Chlorinated Diphenyl Ether Sand Brominated Toluenes by Fish显示文摘 | CARSON W G | 1977 | Chemosphere1977，6，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员