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| 1 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 2 | 强化降压对高血压患者左心室肥厚的影响显示文摘目前尚不清楚超出推荐值的强化降压是否更能降低高血压患者的左心室肥厚(left ventricular hypertrophy,LVH)发生风险,以及LVH风险降低能否解释强化降压的益处。Soliman等纳入收缩压干预试验(systolic blood pressure intervention,SPRINT)中患有高血压但无糖尿病的8164例受试者(平均年龄67.9岁,女性35.3%,31.2%为非洲裔), | 刘莉 叶鹏 Soliman EZ Ambrosius WT Cushman WC Zhang ZM Bates JT Neyra JA Carson TY Tamariz L Ghazi L Cho ME Shapiro BP He J Fine LJ Lewis CE SPRINT Research Study Group | 2017 | 中华高血压杂志2017，25，6： | 2 |
| 3 | Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings显示文摘 | Adler D D Carson P L Rubin J M | 1990 | Ultrasound MedBiol1990，16，6： | 1 |
| 4 | Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinasdmTOR inhibitor显示文摘 | Van Aller G S Carson J D Tang W | 2011 | Biochem Biophys Res Cornmun2011，406，2： | 1 |
| 5 | Red blood cell transfusion: a clinical practice guideline from the AABB 显示文摘 | Carson JL Grossman B J Kleinman S | 2012 | Ann Intern Med2012，157，： | 1 |
| 6 | Analysis of disconnected diallel mating designs II : results from a third generation progeny test of New Zealand Radiata pine improvemenet programme 显示文摘 | J N King M J Carson | 1998 | Silvae Genetica1998，47，23： | 1 |
| 7 | The deformational history of the Larsemann Hills,Prydz Bay:the importance of the Pan-African (500 Ma) in East Antarctica显示文摘 | Dirks P H G M Carson C J Wilson C J L | 1993 | Antarctic Science1993，5，2： | 1 |
| 8 | Particle sizing using passive ultrasonic measurement of particle-wall impact vibrations显示文摘 | Carson G Mulholland A J Nordon A | 2008 | Journal of Sound and Vibration2008，317，12： | 1 |
| 9 | Uncertainty,Opportunism and Governance:The Effects of Volatility and Ambiguity on Formal and Relational Contracting显示文摘 | CARSON S J MADHOK A WU T | 2006 | Academy of Management Journal2006，49，5： | 1 |
| 10 | Chinese students' perception of ESL peer response group interaction显示文摘 | Carson J G Nelson G L | | 0，，01： | 1 |
| 11 | The evidence for dietary prevention and treatment of cardiovascular disease 显示文摘 | van Horn L McCoin M Kris-Etherton P M Burke F Carson J A S Champagne C M | 2008 | Journal of the American Dietetic Association2008，108，： | 1 |
| 12 | Chemistry and biological properties of onions and garlic显示文摘 | Carson J F | 1987 | Food Reviews International1987，3，12： | 1 |
| 13 | Doppler ultrasound flow imaging in the study of breast cancer:Preliminary findings显示文摘 | Alder D D Carson P L Rubin J M | 1990 | UItrasound Med Biol1990，16，6： | 1 |
| 14 | Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings显示文摘 | Alder D D Carson P L Rubin J M | 1990 | Ultrasound Med boi11990，16，4： | 1 |
| 15 | Mechanism of action of Melaleuca alternifolia(tea tree) oil on Staphylococcus aureus determined by time-kill,Lysis,leakage,and salt tolerance assays and electron microscopy显示文摘 | Carson C F Mee B J Riley T V | 2002 | Antimicrob Agents Chemother2002，46，6： | 1 |
| 16 | Use of a polymerase chain reaction assay to detect infection with Eperythrozoon wenyoni in cattle显示文摘 | VANDERVOOT J M BOURNE C CARSON R L | 2001 | Am Vet Med Assoc2001，219，10： | 1 |
| 17 | Meta-analysis of the efficacy of aripiprazole in schizophrenia显示文摘 | Lieberman J Carson WH Sada AR | 2002 | Int J Neuropsychopharmcol2002，，： | 1 |
| 18 | A multilevel investigation of antecedents and consequences of team member boundary-spanning behavior显示文摘 | Marrone J A Tesluk P E Carson J B | 2007 | Academy of Management Journal2007，50，6： | 1 |
| 19 | A Faraday effect optical isolator显示文摘 | L J Aplet J W Carson | 1964 | Appl Opt1964，3，4： | 1 |
| 20 | A Multilevel Investigation of Antecedents and Conse- quences of Team Member Boundary-Spanning Behav- ior显示文摘 | MARRONE J A TESLUK P E CARSON J B | 2007 | Academy of Management Journal2007，50，6： | 1 |
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