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| 1 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 2 | Analysis of peridural scar formation and its prevention after lumbar laminotomy and discectomy in dogs显示文摘 | SONGER M N RAUSCHNING W CARSON E W | 1995 | Spine1995，20，5： | 1 |
| 3 | Sequencing and Valuating Public Goods显示文摘 | Carson R T Flores N E Hanemann M | 1998 | Journal of Environmental Eeonomics and Management1998，，36： | 1 |
| 4 | A Method to Make Use of Thermal Infrared Temperature and NDVI Measurements to Infer Surface Soil Water Content and Fractional Vegetation Cover 显示文摘 | Carson T N Gillies R R Perry E M | 1994 | Remote Sensing Reviews1994，，9： | 1 |
| 5 | Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial显示文摘 | Meduri GU Golden E Freire AX Taylor E Zaman M Carson S J | 2007 | Chest2007，131，4： | 1 |
| 6 | The Importance of Storage, Transfer and Collection 显示文摘 | KNOWLTON T M CARSON J W KLINZING G E | 1994 | Chemical Engineering Progress1994，90，1： | 1 |
| 7 | Efficacy and pharmaeokinetics of bacteriophage therapy in treatment of subciinieal Staphylococcus aureus mastitis in lactating dairy cattle 显示文摘 | Gill J J Paean J C Carson M E eta/ | 2006 | Antimicrobial Agents and Chemotherapy2006，50，9： | 1 |
| 8 | Contingent Valuation and Revealed Preference Methodologies: Com- paring the Estimates for Quasi-public Goods 显示文摘 | Carson R T Flores N E Martin K M | 1996 | Land Economics1996，71，1： | 1 |
| 9 | Atrial fibrillation in pregnancy associated with oral terbutaline显示文摘 | Carson M P Fisher A J Scorza W E | 2002 | Obstet Gynecol2002，100，5： | 1 |
| 10 | Efficacy and pharmacokinetics of bacteriophage therapy in treatment of subclinical Staphylococcus aureus mastitis in lactating dairy cattle显示文摘 | GILL J J PACAN J C CARSON M E | 2006 | Antimicrob Agents Chemother2006，50，9： | 1 |
| 11 | The effect of gastric bypass surgery on hypertension in morbidlyobese patients 显示文摘 | Carson J L Ruddy M E Duff A E | 2004 | Arch Intern Med2004，154，2： | 1 |
| 12 | Contingent valuation and revealed preference methodologies: Comparing the estimates for quasi public goods显示文摘 | Carson R T Flores N E Martin K M | 1996 | Land Economics1996，72，1： | 1 |
| 13 | Irbesartan in patients with heart failure an perserved ejection fraction显示文摘 | MASSIE B M CARSON P E MCMURRAY J J | 2008 | N Engl J Med2008，359，23： | 1 |
| 14 | Effect of supplementation with barium selenate on the fertility, prolificacy and lambing performance of hill sheep 显示文摘 | Mufioz C Carson A F McCoy M A Dawson L E Irwin D Gordon A W Kilpatriek D J | 2009 | The Veterniary Record2009，164，9： | 1 |
| 15 | The biotic response to the late Cenomanian oceanic anoxic event, integrated evidence from Dover, SE England 显示文摘 | Leary P N Carson G A Cooper M K E | 1989 | Journal of the Geological Society1989，146，： | 1 |
| 16 | Genome sequence of Streptococcus mutans UA159,a cariogenic dental pathogen 显示文摘 | Ajdic D McShan W M McLaughlin R E Savie G Chang J Carson M B | 2002 | Proc Natl Aead Sci USA2002，99，14： | 1 |
| 17 | Nurses' work: balancing personaland professional caregiving careers 显示文摘 | Ross MM Rideout E Carson M | 1994 | Can J Nurs Res1994，26，4： | 1 |
| 18 | Use of portion-controlled entrees enhances weight loss in women 显示文摘 | HANNUM S M CARSON L EVANS E M | 2004 | Obes Res2004，12，3： | 1 |
| 19 | Interleuldn IL - 15 is a novel cytokine that activates human natural killer cells via compo- nents of the IL - 2 receptor显示文摘 | Carson W E Lindemann 1~1 J Linett M L | 1994 | J Exp Ned1994，180，： | 1 |
| 20 | Hydrodynamics in three Arctic lakes 显示文摘 | CARSON C E HUSSEY K M | 1960 | The Journal of Geology1960，68，： | 1 |
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