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| 1 | 睾酮缺乏症的诊断和治疗显示文摘近些年来,随着睾酮缺乏症(TD)发病率的上升、新药的不断开发、以及商业推广的深入,睾酮替代疗法(TST)的临床应用显著增多。然而,关于睾酮缺乏症的诊断标准以及TST的应用和监测,仍然不是很明确。此种现象主要源于睾酮的多重作用靶点。在人体内,睾酮参与了很多生理过程的调节,同时睾酮的表达水平也受很多疾病及药物的影响。因此,睾酮缺乏症的临床症状和体征具有多样性和非特异性,也就增加了睾酮缺乏症的诊断难度,尤其在老年人群中。临床上,关于血清睾酮水平的检测也存在争议,不同实验室之间存在一定的差异,因此也很难界定睾酮水平的诊断标准。很多医学专业组织试图制定睾酮缺乏症的诊断指南,但彼此间很难达成统一。另外,临床使用的睾酮制剂也层出不穷,相应的TST治疗方案也像TD的诊断标准一样不断更新和变化。临床上,随着TST的不断推进,专科医师必须不断更新对于TD和HTST的了解和治疗及应用。本文旨在阐述TD的最新概念及其诊断和治疗的新进展。 | James A McBride Culley C Carson Robert M Coward | 2015 | Asian Journal of Andrology2015，17，2： | 5 |
| 2 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 3 | Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings显示文摘 | Adler D D Carson P L Rubin J M | 1990 | Ultrasound MedBiol1990，16，6： | 1 |
| 4 | Analysis of peridural scar formation and its prevention after lumbar laminotomy and discectomy in dogs显示文摘 | SONGER M N RAUSCHNING W CARSON E W | 1995 | Spine1995，20，5： | 1 |
| 5 | Smac is required for cytochrome C - induced apoptosis in prostate cancer LNCaP cells 显示文摘 | Carson JP Behnam M Jennifer N | 2002 | Cancer Research2002，62，： | 1 |
| 6 | Gene vaccination with naked plasmid DNA: mechanism of CTL priming 显示文摘 | Corr M Lee DJ Carson DA | 1996 | J Exp Med1996，184，： | 1 |
| 7 | Role of Bentonite in Prevention of T-2 Toxicosis in Rats显示文摘 | Carson M S Smith T K | 1983 | J Anim Sci1983，57，6： | 1 |
| 8 | Association between BRAFV600E mutation and recurrence of papillary thyroid cancer 显示文摘 | Xing M Alzahrani AS Carson KA | 2015 | J Clin Oncol2015，33，1： | 1 |
| 9 | Hyperbaric oxygen therapy for stroke: A systematic review of the evidence显示文摘 | Carson S McDonagh M Russman B | 2005 | Clin Rehabil2005，19，8： | 1 |
| 10 | Analysis of disconnected diallel mating designs II : results from a third generation progeny test of New Zealand Radiata pine improvemenet programme 显示文摘 | J N King M J Carson | 1998 | Silvae Genetica1998，47，23： | 1 |
| 11 | Sequencing and Valuating Public Goods显示文摘 | Carson R T Flores N E Hanemann M | 1998 | Journal of Environmental Eeonomics and Management1998，，36： | 1 |
| 12 | The deformational history of the Larsemann Hills,Prydz Bay:the importance of the Pan-African (500 Ma) in East Antarctica显示文摘 | Dirks P H G M Carson C J Wilson C J L | 1993 | Antarctic Science1993，5，2： | 1 |
| 13 | A new gene in maize conferring the chlorotic halo reac- tion to infection by exserohilum-tureicum显示文摘 | Carson M L | 1995 | Plant Disease1995，79，： | 1 |
| 14 | The evidence for dietary prevention and treatment of cardiovascular disease 显示文摘 | van Horn L McCoin M Kris-Etherton P M Burke F Carson J A S Champagne C M | 2008 | Journal of the American Dietetic Association2008，108，： | 1 |
| 15 | A Method to Make Use of Thermal Infrared Temperature and NDVI Measurements to Infer Surface Soil Water Content and Fractional Vegetation Cover 显示文摘 | Carson T N Gillies R R Perry E M | 1994 | Remote Sensing Reviews1994，，9： | 1 |
| 16 | Doppler ultrasound flow imaging in the study of breast cancer:Preliminary findings显示文摘 | Alder D D Carson P L Rubin J M | 1990 | UItrasound Med Biol1990，16，6： | 1 |
| 17 | Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings显示文摘 | Alder D D Carson P L Rubin J M | 1990 | Ultrasound Med boi11990，16，4： | 1 |
| 18 | A modular spinal rod linkage system to provide rotational stability显示文摘 | Asher M Carson W Heinig C | 1988 | Spine1988，13，3： | 1 |
| 19 | Use of a polymerase chain reaction assay to detect infection with Eperythrozoon wenyoni in cattle显示文摘 | VANDERVOOT J M BOURNE C CARSON R L | 2001 | Am Vet Med Assoc2001，219，10： | 1 |
| 20 | Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings 显示文摘 | ADLER D D CARSON P L RUBIN J M | 1990 | Utrasound Med Biol1990，16，： | 1 |
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