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| 1 | 睾酮缺乏症的诊断和治疗显示文摘近些年来,随着睾酮缺乏症(TD)发病率的上升、新药的不断开发、以及商业推广的深入,睾酮替代疗法(TST)的临床应用显著增多。然而,关于睾酮缺乏症的诊断标准以及TST的应用和监测,仍然不是很明确。此种现象主要源于睾酮的多重作用靶点。在人体内,睾酮参与了很多生理过程的调节,同时睾酮的表达水平也受很多疾病及药物的影响。因此,睾酮缺乏症的临床症状和体征具有多样性和非特异性,也就增加了睾酮缺乏症的诊断难度,尤其在老年人群中。临床上,关于血清睾酮水平的检测也存在争议,不同实验室之间存在一定的差异,因此也很难界定睾酮水平的诊断标准。很多医学专业组织试图制定睾酮缺乏症的诊断指南,但彼此间很难达成统一。另外,临床使用的睾酮制剂也层出不穷,相应的TST治疗方案也像TD的诊断标准一样不断更新和变化。临床上,随着TST的不断推进,专科医师必须不断更新对于TD和HTST的了解和治疗及应用。本文旨在阐述TD的最新概念及其诊断和治疗的新进展。 | James A McBride Culley C Carson Robert M Coward | 2015 | Asian Journal of Andrology2015，17，2： | 5 |
| 2 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 3 | The evidence for dietary prevention and treatment of cardiovascular disease 显示文摘 | van Horn L McCoin M Kris-Etherton P M Burke F Carson J A S Champagne C M | 2008 | Journal of the American Dietetic Association2008，108，： | 1 |
| 4 | MUC1:A multifunctional cell surface component of reproductive tissue epithelia显示文摘 | Brayman M Thathiah A Carson DD | 2004 | Repro Biol & Endocrin2004，2，： | 1 |
| 5 | 'Unexplained' somatic symptoms, functional syndromes, and somatization: do we need a paradigm shift?显示文摘 | Sharp M Carson A | 2001 | Ann Intern Med2001，134，2： | 1 |
| 6 | Late-onset chronic inflammatory encephalopathy in immune competent and severe combined-immune deficient (SCID) mice with astrocyte-targeted expression of tumor necrosis factor显示文摘 | Stalder AK Carson M J Pagenstecher A at el | 1998 | AmJ Pathol1998，153，3： | 1 |
| 7 | Is maximum conservative management an equivalent treatment option to dialysis for elderly patients with significant comorbid disease? 显示文摘 | Carson RC Juszczak M Davenport A | 2009 | Clin J Am Soc Nephrol2009，4，10： | 1 |
| 8 | Inhibition of HER-kinase activation prevents ERK-mediated degradation of PPARgamma 显示文摘 | Hedvat M Jain A Carson D A st al | 2004 | Cancer Cell2004，5，6： | 1 |
| 9 | Atrial fibrillation in pregnancy associated with oral terbutaline显示文摘 | Carson M P Fisher A J Scorza W E | 2002 | Obstet Gynecol2002，100，5： | 1 |
| 10 | The effect of gastric bypass surgery on hypertension in morbidlyobese patients 显示文摘 | Carson J L Ruddy M E Duff A E | 2004 | Arch Intern Med2004，154，2： | 1 |
| 11 | Inhibiting sulfate reducing bacteria in biofilms on steel with antimierobial pep tides generated in situ显示文摘 | Jayaraman A Halloek P J Carson R M | 1999 | Applied Microbiology and Biotechnology1999，52，2： | 1 |
| 12 | Regulation of sex hormone-binding globulin production by isoflavonoids and patterns of isoflavonoid conjugation in HepG2 cell cultures显示文摘 | Loukovaara M Carson M Palotie A | 1995 | Steroids1995，60，9： | 1 |
| 13 | Functional mapping of an AcNPV immediate early gene which augments expression of the IE-1 transactivated 39k gene显示文摘 | Carson D D Guarino L A Summers M O | 1988 | Virology1988，162，： | 1 |
| 14 | Effect of supplementation with barium selenate on the fertility, prolificacy and lambing performance of hill sheep 显示文摘 | Mufioz C Carson A F McCoy M A Dawson L E Irwin D Gordon A W Kilpatriek D J | 2009 | The Veterniary Record2009，164，9： | 1 |
| 15 | Transient expression of the Autographa californica nuclear polyhedrosis virus immediate-early gene,IE-N,is regulated by three viral elements显示文摘 | Carson D D Summers M D Guarino L A | 1991 | J Virol1991，65，： | 1 |
| 16 | Expression profilingof cytokinin action in Arabidopsis显示文摘 | RASHOTTE A M CARSON S D B TO J P C | 2003 | Plant Physiol2003，132，： | 1 |
| 17 | Is maximum conservative management an equivalent treatment option to dialysis for eld- erly patients with significant comorbid disease显示文摘 | Carson R C Juszczak M Davenport A | 2009 | Clin J Am Soc Nephrol2009，4，： | 1 |
| 18 | The biotic response to the late Cenomanian oceanic anoxic event, integrated evidence from Dover, SE England 显示文摘 | Leary P N Carson G A Cooper M K E | 1989 | Journal of the Geological Society1989，146，： | 1 |
| 19 | Apoptosis and disease显示文摘 | Carson D A Ribeiro J M | 1993 | Lancet1993，341，8855： | 1 |
| 20 | The Impact of Health Literacy on Desire for Participation in Heahhcare, Medical Visit Communication, and Patient Reported Outcomes among Patients with Hypertension显示文摘 | Aboumatar H J Carson K A Beach M C | 2013 | Journal of general internal medicine2013，28，11： | 1 |
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