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| 1 | 散鳞镜鲤与兴国红鲤、龙州镜鲤的杂种优势以及鳞被、体色的遗传显示文摘本研究希望通过鲤鱼品种间杂交出现的杂种优势来提高鲤鱼的产量以及在杂种的后代中选择具有优良的经济性状的类型培育出新的鲤鱼品种。两组杂交的杂种一代具有明显的杂种优势,可以直接应用于渔业生产上并可望获得增产效果。根据对鳞被和体色的遗传特性的研究结果断定散鳞镜鲤与兴国红鲤的杂种二代中出现的红色镜鲤的鳞被和体色是由纯合型隐性基因控制的,可以预期它的后代不再出现分离而可能成为一个稳定的新品种。研究了不同品种及其杂种的血清蛋白聚丙烯酰胺盘状电泳图谱,希望借此作为一种选种的工具。 | Subgroup of Carp Studies,Section of Fish Breeding,Laboratory of Fish Genetics Breeding,Institute of Hydrobiology,Hupei Province | 1975 | 水生生物学集刊1975，5，4： | 11 |
| 2 | Insulin-mimetic compound hexaquis(benzylammonium) decavanadate is antilipolytic in human fat cells显示文摘AIM To assess in rodent and human adipocytes the antilipolytic capacity of hexaquis(benzylammonium) decavanadate(B6V10), previously shown to exert antidiabetic effects in rodent models, such as lowering free fatty acids(FFA) and glucose circulating levels.METHODS Adipose tissue(AT) samples were obtained after informed consent from overweight women undergoing plastic surgery. Comparison of the effects of B6V10 and reference antilipolytic agents(insulin,benzylamine,vanadate) on the lipolytic activity was performed on adipocytes freshly isolated from rat, mouse and human AT. Glycerol release was measured using colorimetric assay as an index of lipolytic activity. The influence of B6V10 and reference agents on glucose transport into human fat cells was determined using the radiolabelled 2-deoxyglucose uptake assay.RESULTS In all the species studied, B6V10 exhibited a dosedependent inhibition of adipocyte lipolysis when triglyceride breakdown was moderately enhanced by β-adrenergic receptor stimulation. B6V10 exerted on human adipocyte a maximal lipolysis inhibition of glycerol release that was stronger than that elicited by insulin. However, B6V10 did not inhibit basal and maximally stimulated lipolysis. When incubated at dose ≥ 10 μmol/L, B6V10 stimulated by twofold the glucose uptake in human fat cells, but-similarly to benzylamine-without reaching the maximal effect of insulin, while it reproduced one-half of the insulin-stimulation of lipogenesis in mouse fat cells. CONCLUSION B6V10 exerts insulin-like actions in adipocytes, including lipolysis inhibition and glucose transport activation. B6V10 may be useful in limiting lipotoxicity related to obesity and insulin resistance. | Christian Carpéné Silvia Garcia-Vicente Marta Serrano Luc Marti ChloéBelles Miriam Royo Jean Galitzky Antonio Zorzano Xavier Testar | 2017 | World Journal of Diabetes2017，8，4： | 2 |
| 3 | Vanadium-dependent activation of glucose transport in adipocytes by catecholamines is not mediated via adrenoceptor stimulation or monoamine oxidase activity显示文摘BACKGROUND Benzylamine and methylamine activate glucose uptake in adipocytes.For tyramine,this effect has even been extended to cardiomyocytes.AIM To investigate the effects of catecholamines and other amines on glucose uptake.METHODS A screening compared 25 biogenic amines on 2-deoxyglucose(2-DG)uptake activation in rat adipocytes.Pharmacological approaches and transgenic mouse models were then used to decipher the mode of action of several hits.RESULTS In rat adipocytes,insulin stimulation of 2-DG uptake was reproduced with catecholamines.100μmol/L or 1 mmol/L adrenaline,noradrenaline,dopamine and deoxyepinephrine,maximally activated hexose transport only when sodium orthovanadate was added at 100μmol/L.Such activation was similar to that already reported for benzylamine,methylamine and tyramine,well-recognized substrates of semicarbazide-sensitive amine oxidase(SSAO)and monoamine oxidase(MAO).Several,but not all,tested agonists ofβ-adrenoreceptors(β-ARs)also activated glucose transport whileα-AR agonists were inactive.Lack of blockade byα-andβ-AR antagonists indicated that catecholamine-induced 2-DG uptake was not mediated by AR stimulation.Adipocytes from mice lackingβ1-,β2-andβ3-ARs(triple KO)also responded to millimolar doses of adrenaline or noradrenaline by activating hexose transport in the presence of 100μmol/L vanadate.The MAO blocker pargyline,and SSAO inhibitors did not block the effects of adrenaline or noradrenaline plus vanadate,which were blunted by antioxidants.CONCLUSION Catecholamines exert unexpected insulin-like actions in adipocytes when combined with vanadium.For limiting insulin resistance by activating glucose consumption at least in fat stores,we propose that catecholamine derivatives combined with vanadium can generate novel complexes that may have low toxicity and promising anti-diabetic properties. | Jessica Fontaine Geneviève Tavernier Nathalie Morin Christian Carpéné | 2020 | World Journal of Diabetes2020，11，12： | 2 |
| 4 | Photoinduced reactivity of titanium dioxide显示文摘 | O. Carp C.L. Huisman A. Reller | 2004 | Progress in Solid State Chemistry2004，，1： | 2 |
| 5 | Photoinduced reactivity of titanium dioxide 显示文摘 | Carp O Huisman L Relier A | 2004 | Progress in Solid State Chemistry2004，32，： | 1 |
| 6 | Photoinduced reactivityof titanium dioxide显示文摘 | Carp O Huisman C L Reller A | 2004 | Progress in Solid State Chemis-try2004，32，12： | 1 |
| 7 | Pregnancy complicated by aortic dissection: caesarean delivery during extradural anaesthesia显示文摘 | Jayaram A Carp HM Davis L | 1995 | Br J Anaesth1995，75，3： | 1 |
| 8 | Parental karyotype andsubsequentlive births in recurrent misearriage显示文摘 | CARP H FELDMAN B OELSNER Q | 2004 | Fertility and Sterifity2004，81，5： | 1 |
| 9 | Cytokines in reccurrent miscarriage 显示文摘 | Carp H | 2004 | Lupus2004，13，9： | 1 |
| 10 | Parental karyotype and subsequent live births in recurrent miscarriage 显示文摘 | Carp H Feldman B Oelsner Q | 2004 | Fertil Steril2004，81，5： | 1 |
| 11 | TNF-ain prognancy loss and embryo maldevelopment: a mediator of detrimental stimuli or a protector of the fetoplacental unit显示文摘 | Toder V Fein A Carp H at al | 2003 | Assisted Reproduction and Genetics2003，20，2： | 1 |
| 12 | Recurent miscarriage:Genetic factors and assessment ofthe embryo显示文摘 | Carp H J | 2008 | IMAJ2008，10，3： | 1 |
| 13 | Thromboprophylaxis improves the live birth rate in women with consecutive recurrent miscarriages and he- reditary thrombophilia 显示文摘 | Carp H Dolitzky M Inbal A | 2003 | J Thromb Haemost2003，1，3： | 1 |
| 14 | Cytokines in recurrent miscarriage显示文摘 | Carp H | 2004 | Lupus2004，13，： | 1 |
| 15 | Autoantibodies as predic- tors of pregnancy complications显示文摘 | Carp HJA Meroni PL Shoenfeld Y | 2008 | Rheumatology2008，47，： | 1 |
| 16 | Karyotype of the abortus in recurrent miscarriage显示文摘 | Carp H Toder V Aviram A et aI | 2001 | Fertil Steril2001，75，： | 1 |
| 17 | Photoinduced reactivity of titanium dioxide显示文摘 | CARP O HUISMAN C L RELLER A | 2004 | A Progress In Solid Chemistry2004，32，： | 1 |
| 18 | Optimization of an offset reflector antenna using genetic algorithms显示文摘 | Avila S L Carpes W P Vasconcelos J A | 2004 | IEEE Trans on Magnetics2004，40，2： | 1 |
| 19 | Effects of granulocyte-macrophage colony-stimulating factor on wound contraction显示文摘 | Robson M Kucukcelebi A Carp SS | 1994 | Eur J Clin Microbiol Infect Dis1994，132，： | 1 |
| 20 | Parental karyotype and subsequentlive births in recurrent miscarriage 显示文摘 | Carp H Feldman B Oelsner Q | 2004 | Fertility and Sterility2004，81，5： | 1 |
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