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| 1 | Colon cancer and the immune system:The role of tumor invading T cells显示文摘Colon cancer is still one of the leading causes of cancer death worldwide. Although the host immune system has been shown to react against tumor cells, mainly through tumor infi ltrating lymphocytes and NK cells, tumor cells may utilize different ways to escape anti-tumor immune response. Tumor infi ltration of CD8+ and CD4+ (T-bet+) effector T cells has been attributed to a beneficial outcome, and the enhancement of T cell activation through T cell receptor stimulation and co-stimulatory signals provides promising strategies for immunotherapy of colon cancer. Growing evidence supports a role for the Fas/FasL system in tumor immunology, although the mechanisms and consequences of FasL activation in colon cancer are not completely understood. In animal models, depletion of regulatory T cells (CD4+ CD25+ T cells) can enhance the anti-tumor immune response under certain conditions. Taken together, recent insights in the immune reaction against colon carcinoma have provided new approaches to immunotherapy, although much remains to be learned about the exact mechanisms. | Maximilian Waldner Carl C Schimanski Markus F Neurath | 2006 | World Journal of Gastroenterology2006，12，45： | 15 |
| 2 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 3 | Osteoclast activity modulates B-cell development in the bone marrow显示文摘B 房间开发开是依赖的在 B 房间先锋和骨头髓 stromal 房间之间的相互作用,而是在这的骨破折(OCL ) 的角色处理未知的遗体。B lymphocytopenia 是 osteopetrosis 的一个特征,建议由 OCL 活动的 B 淋巴细胞增殖的调整。探讨这个问题,我们首先由树枝状的房间转移在 osteopetrotic oc/oc 鼠标救了 OCL 功能,导致骨头显型和 B 房间开发的恢复。为了推进,探索在 OCL 活动和 B 淋巴细胞增殖之间的连接,我们由 zoledronic 酸(ZA ) 的注射在正常老鼠导致了 osteopetrosis,骨头再吞的一个禁止者。B 房间数字在对待 ZA 的老鼠的骨头髓明确地减少了。ZA 直接没影响 B 房间区别,增长和 apoptosis,但是由 stromal 房间在 CXCL12 和 IL-7 的表示导致减少,与减少的 osteoblastic 约会联系了。在 oc/oc 老鼠的相等的低 osteoblastic 约会证实它在造骨细胞上源于减少的 OCL 活动而非从 ZA 的直接效果。骨头微型环境的这些戏剧的改变为 B 淋巴细胞增殖是不利的,导致在他们在导致 ZA 的 osteopetrotic 模型的骨头髓壁龛外面的 B 房间祖先的保留。总的来说,我们的数据表明 OCL 由控制骨头微型环境和造骨细胞的命运在骨头髓调制 B 房间开发。他们由 OCL 活动在他们的壁龛为 B 房间的保留的规定提供新奇基础。 | Anna Mansour | 2011 | Cell Research2011，21，7： | 6 |
| 4 | Environmental production functions and environmental directional distance functions显示文摘 | Rolf F?re Shawna Grosskopf Carl A. Pasurka | 2006 | Energy2006，，7： | 2 |
| 5 | History - high Speed Network Monitoring and Analysis 显示文摘 | DRESSLER F CARLE G | 2005 | In Proceedings of the 24th IEEE Conference on Computer Communications (IEEE INFOCOM 2005)2005，，： | 1 |
| 6 | Three-Dimensional Hydrofacies Modeling Based on Soil Surveys and Transition Probability Geostatistics显示文摘 | Weissmann G S Carle S F Fogg G E | 1999 | Water Resources Research1999，35，： | 1 |
| 7 | LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator显示文摘 | Davide N Mauri Reinhard Ebner Rebecca I Montgomery Kristine D Kochel Timothy C Cheung Guo-Liang Yu Steve Ruben Marianne Murphy Roselyn J Eisenberg Gary H Cohen Patricia G Spear Carl F Ware | 1998 | Immunity1998，，： | 1 |
| 8 | Construction of sand shinnery oak communities of the Llano Estacado: Animal disturbances, plant community structure, and restoration显示文摘 | Shivcharn S Dhillion Mark A McGinley Carl F Friese | 1994 | Restoration Ecology1994，2，1： | 1 |
| 9 | Functional properties of anthocyanins and betalains in plants, food, and in human nutrition 显示文摘 | Stintzing F C Carle R | 2004 | Trends Food Sci Technol2004，15，： | 1 |
| 10 | Functional properities of antho- cyanins and betalains in plants, food,and in human nutrition 显示文摘 | STINGZING F C CARLE R | 2004 | Trends in Food Science and Technology2004，15，3： | 1 |
| 11 | New Percutaneous Access Method for Minimally Invasive Anterior Lumbosacral Surgery显示文摘 | CRAGG A CARL A CASTENEDA F | 2004 | J Spinal Disord Tech2004，17，1： | 1 |
| 12 | Pathogen analysis and genetic predisposition testing using microelectronic arrays and isothermal amplification显示文摘 | Carl F Edman | 2000 | J Invest Med2000，32，： | 1 |
| 13 | Pthogen analysis and genetic predisposition testing using microelectronic arrays and isothermal amplification显示文摘 | Carl F Edman | 2000 | Invest Med2000，2，： | 1 |
| 14 | Heterogeneity ofgenome sizes within the genus Spiroplasma显示文摘 | Carle P Laigret F Tully JG | 1995 | International Journal of Systematic Bacteriology1995，45，1： | 1 |
| 15 | Quality and authenticity control of fruit purées,fruit preparations and jams:a review显示文摘 | F(U)GEL R CARLE R SCHIEBER A | 2005 | Trends in Food Science & Technology2005，16，： | 1 |
| 16 | New percutaneous access method for minimally invasive anterior lumbosacral surgery显示文摘 | Cragg A Carl A Casteneda F | 2004 | J Spinal Disord Tech2004，17，1： | 1 |
| 17 | Helerogeneity of genome sizes within the genus spiroplasma显示文摘 | Carle P Laigret F Tully J G | 1995 | J System Bacteriol1995，45，： | 1 |
| 18 | Lung protective mechanical ventilation in acute respiratory distress syndrome显示文摘 | Carl F | 2003 | Respir Care Clin2003，9，： | 1 |
| 19 | Evolution of the structure of a gas-liquid two-phase flow in a large vertical pipe 显示文摘 | Prasser H M Beyer M Carl H Gregor S Lucas D Pietruske H Schutz P Weiss F P | 2007 | Nuclear Engineering and Design2007，237，： | 1 |
| 20 | Transition probability based indicator geostatistics显示文摘 | Carle S F Fogg G E | 1996 | Mathematical Geology1996，28，4： | 1 |
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