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| 1 | Intestinal barrier: A gentlemen's agreement between microbiota and immunity显示文摘Our body is colonized by more than a hundred trillion commensals, represented by viruses, bacteria and fungi. This complex interaction has shown that the microbiome system contributes to the host's adaptation to its environment, providing genes and functionality that give flexibility of diet and modulate the immune system in order not to reject these symbionts. In the intestine,specifically, the microbiota helps developing organ structures, participates of the metabolism of nutrients and induces immunity. Certain components of the microbiota have been shown to trigger inflammatory responses, whereas others, anti-inflammatory responses.The diversity and the composition of the microbiota,thus, play a key role in the maintenance of intestinal homeostasis and explain partially the link between intestinal microbiota changes and gut-related disorders in humans. Tight junction proteins are key molecules for determination of the paracellular permeability. In the context of intestinal inflammatory diseases, the intestinal barrier is compromised, and decreased expression and differential distribution of tight junction proteins is observed. It is still unclear what is the nature of the luminal or mucosal factors that affect the tight junctionproteins function, but the modulation of the immune cells found in the intestinal lamina propria is hypothesized as having a role in this modulation. In this review,we provide an overview of the current understanding of the interaction of the gut microbiota with the immune system in the development and maintenance of the intestinal barrier. | Andrea Moro Caricilli Angela Castoldi Niels Olsen Saraiva Cmara | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，1： | 11 |
| 2 | Topira- mate treatment improves hypothalamic insulin and leptin sig- naling and action and reduces obesity in mice 显示文摘 | Caricilli AM Penteado E de Abreu LL | 2012 | Endocri nology2012，153，44： | 1 |
| 3 | C-ut micro biota is a key modulator of insulin resistance in TLR 2 knockout mice显示文摘 | Caricilli AM Picardi PK De Abreu L L | 2011 | PLoS Biol2011，9，12： | 1 |
| 4 | Gut mierobiota composition and its effects on obesity and insulin resistance显示文摘 | Caricilli AM Saad MJ | 2014 | Curr Opin Clin Nutr Metab Care2014，17，4： | 1 |
| 5 | Inhibition of toll like receptor 2 expression improves insulin sensitiv ity and singnaling in muscle and white adipose tissue of mice fed a high-fat diet 显示文摘 | Caricilli AM Nascimento PH Pauli JR | 2008 | Journal of Endocrinology2008，199，3： | 1 |
| 6 | Inhibi- tion of toll like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet显示文摘 | Caricilli AM Nascimento PH Pauli JR | 2008 | Journal of Endo- crinology2008，199，3： | 1 |
| 7 | Topical insulin accelerates wound healing in diabetes by enhancing the AKT and ERK pathways:a double-blind placebo-controlled clinical trial显示文摘 | Lima MH Caricilli AM de Abreu LL | 2012 | PLoS One2012，7，36： | 1 |
| 8 | Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice显示文摘 | Caricilli AM Picardi PK de Abreu LL | 2011 | PLoS Biol2011，9，10： | 1 |
| 9 | The role of gut microbiota on insulin resistance显示文摘 | Caricilli A M Saad M J | | 0，，03： | 1 |
| 10 | Topical in- sulin accelerates wound healing in diabetes by enhancing the AKT and ERK pathways: a double-blind placebo-controlled clinical trial显示文摘 | Lima M H Caricilli A M de Abreu L L | 2012 | PLoS One2012，7，36： | 1 |
| 11 | Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet显示文摘 | Caricilli AM Nascimento PH Pauli JR | 2008 | J Endocrinol2008，199，3： | 1 |
| 12 | Topiramate treatment improves hypothalamic insulin and leptin signaling and action and re- duces obesity in mice 显示文摘 | Caricilli AM Penteado E de Abreu LL | 2012 | Endocrinology2012，153，9： | 1 |
| 13 | Topiramate treat-ment improves hypothalamic insulin and leptin signaling and ac-tion and reduces obesity in mice显示文摘 | Caricilli AM Penteado E de Abreu LL | 2012 | Endocrinology2012，153，9： | 1 |
| 14 | Gut microbiota is a key modulator of insulin resistance in TLR2 knockout mice显示文摘 | Caricilli AM Picardi PK de Abreu LL | | 0，，： | 1 |
| 15 | Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet显示文摘 | Caricilli AM Nascimento PH Pauli JR | 2008 | J Endocrinol2008，199，3： | 1 |
| 16 | Inhibi- tion of Toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet显示文摘 | CARICILLI A M NASCIMENTO P H PAULI J R | 2008 | J Endocrino12008，199，3： | 1 |
| 17 | Gut mi- crobiota is a key modulator of insulin resistance in TLR 2 knock- out mice显示文摘 | CARICILLI A M PICARDI P K DE ABREU L L | 2011 | PLoS Biol2011，9，10： | 1 |
| 18 | The role of gut microbiota on in- sulin resistance显示文摘 | CARICILLI AM SAAD MJ | 2013 | Nutrients2013，5，3： | 1 |
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