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239篇 您的检索式：作者名="Cardone M"

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	题名	作者	年代	出处	被引量
1	Evidence for the involvement of NOD2 in regulating colonic epithelial cell growth and survival显示文摘AIM: To investigate the function of NOD2 in colonic epithelial cells (CEC). METHODS: A combination of in vivo and in vitro analyses of epithelial cell turnover in the presence and absence of a functional NOD2 protein and, in response to enteric Salmonella typhimurium infection, were used. shRNA interference was also used to investigate the consequences of knocking down NOD2 gene expression on the growth and survival of colorectal carcinoma cell lines. RESULTS:In the colonic mucosa the highest levels of NOD2 expression were in proliferating crypt epithelial cells. Muramyl dipeptide (MDP), that is recognized by NOD2, promoted CEC growth in vitro . By contrast,the growth of NOD2-deficient CECs was impaired. In vivo CEC proliferation was also reduced and apoptosis increased in Nod2-/- mice, which were also evident following enteric Salmonella infection. Furthermore, neutralization of NOD2 mRNA expression in human colonic carcinoma cells by shRNA interference resulted in decreased survival due to increased levels of apoptosis. CONCLUSION: These findings are consistent with the involvement of NOD2 protein in promoting CEC growth and survival. Defects in proliferation by CECs in cases of CD may contribute to the underlying pathology of disrupted intestinal homeostasis and excessive inflammation.	Sheena M Cruickshank Louise Wakenshaw John Cardone Peter D Howdle Peter J Murray Simon R Carding	2008	World Journal of Gastroenterology2008，14，38：	3
2	TBM performance estimation using rock mass classifications显示文摘	M Sapigni M Berti E Bethaz A Busillo G Cardone	2002	International Journal of Rock Mechanics and Mining Sciences2002，，6：	3
3	Val66Met BDNFGenotypes in melancholic depression: effects on brain struc-ture and treatment outcome显示文摘	Cardoner N Soria V Gratacos M	2013	Depress Anxiety2013，30，3：	1
4	Shaking table tests on reinforced concrete frames with different isolation systems显示文摘	Dolce M Cardone D Ponzo F	2007	Earthquake Engineering and Structural Dynamics2007，36，5：	1
5	Mechanical behavior of shape memory alloys for seismic applications 2: austenite NiTi wires subjected to tension显示文摘	Dolce M Cardone D	2001	International Journal of Mechanical Sciences2001，43，11：	1
6	Infrared thermography for convective heat transfer measurements 显示文摘	Carlomagno G M Cardone G	2010	Experiments in Fluids2010，49，6：	1
7	Reciprocal activating interaction between dendritic cells and pamidronate-stimulated gamma delta T cells:role of CD86and inflammatory cytokines显示文摘	Conti L Casetti R Cardone M Varano B Martino A Belardelli F Poccia F Gessani S	2005	J Immunol2005，174，1：	1
8	Identification of small-molecule inhibitors of in- teraction between the BH3 domain and Bcl-XL 显示文摘	DEGTEREV A LUGOVSKOY A CARDONE M	2001	Nat Cell Bio12001，3，2：	1
9	Comparative evaluation of standard criteria and CA-125 in ovarian cancers treated with platinum or paclitaxel 显示文摘	Balbi GC Cardone A Passaro M	2005	Eur J Gynaecol Oncol2005，26，3：	1
10	A study on the mechanical behaviour of cement-bitumen treated materials显示文摘	BOCCI M GRILLI A CARDONE F	2011	Construction and Building Materials2011，25，2：	1
11	Genome-wide association studies for complex traits: consensus, uncertainty and challenges 显示文摘	MCCARTHY M I ABECASIS G R CARDON L R	2008	Nat Rev Genet2008，9，：	1
12	Implementation and Testing of Passive Control Devices Based on Shape Memory Alloys 显示文摘	Dolce M Cardone D Marnetto R	2000	Earthquake Engineering and Structural Dynamics2000，29，：	1
13	Implementation and tes- ting of passive control devices based on shape memory al- loys 显示文摘	Dolce M Cardone D Marnetto R	2000	Earthquake Engineering and Structural Dyna- mics2000，29，：	1
14	Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL显示文摘	Degterev A Lugovskoy A Cardone M	2001	Nat Cell Biol2001，3，2：	1
15	Adopting HRM practices and their effectiveness in small firms facing product-market zompetition显示文摘	Patel P C Cardon M S	2010	Human Resource Management2010，49，2：	1
16	Implementation and testing of passive control devices based on shape memory alloys 显示文摘	Dolce M Cardone D Mametto R	2000	Earthquake engineering and structuraldynamics2000，29，：	1
17	Misfortunes or Mistakes? Cultural Sensemaking of Entrepreneurial Failure 显示文摘	CARDON M S STEVENS C E POTTER D R	2011	Journal of Business Venturing2011，26，1：	1
18	Infrared thermography for convective heat transfer measurements 显示文摘	Carlomagno G M Cardone G	2010	Experiments in Fluids2010，49，6：	1
19	Identification of small molecule inh ibitors of interaction between the BH3 domain and Bcl-XL显示文摘	Degterev A Lugovskoy A Cardone M	2001	Nat Cell Biol2001，3，：	1
20	Reciprocal acti- vating interaction between dendritic cells and pamidr- onate-stimulated gammade!ta T cells; role of CD8fi and inflammatory cytokines显示文摘	Conti L Casetti R Cardone M	2005	J Immunol2005，174，1：	1

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