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| 1 | Effect of perioperative blood transfusion on clinical outcomes in hepatic surgery for cancer显示文摘Allogeneic blood transfusion during liver resection for malignancies has been associated with an increased incidence of different types of complications: infectious complications, tumor recurrence, decreased survival. Even if there is clear evidence of transfusion-induced immunosuppression, it is difficult to demonstrate that transfusion is the only determinant factor that decisively affects the outcome. In any case there are several motivations to reduce the practice of blood transfusion. The advantages and drawbacks of different transfusion alternatives are reviewed here, emphasizing that surgeons and anesthetists who practice in centers with a high volume of liver resections, should be familiar with all the possible alternatives. | Gianlorenzo Dionigi Luigi Boni Francesca Rovera Stefano Rausei Salvatore Cuffari Giovanni Cantone Alessandro Bacuzzi Renzo Dionigi | 2009 | World Journal of Gastroenterology2009，15，32： | 10 |
| 2 | Therapeutic options for HER-2 positive breast cancer: Perspectives and future directions显示文摘During the last 15 years we have witnessed an unprecedented expansion in the drugs developed to target human epidermal growth factor receptor-2(HER-2) positive breast cancer. Trastuzumab, pertuzumab, adotrastuzumab emtansine and lapatinib are currently food and drug administration(FDA)-approved for the treatment of breast cancer patients with HER-2 overexpressed. However, given the amount of information gathered from years of uninterrupted clinical research, it is essential to have periodic updates that succinctly recapitulate what we have learnt over these last years and help us to apply that information in our daily practice. This review will pursue that objective. We will summarize the most relevant and updated informationrelated to the state of the art management of HER-2 positive breast cancer in all the clinical scenarios including the adjuvant, neoadjuvant and metastatic settings. But we will also critically appraise that literature in order to highlight some key clinical concepts that should not be overlooked. Lastly, this review will also point out some of the most promising strategies that are currently being tested and may soon become available. | Gonzalo Recondo Jr Enrique Dìaz Canton Màximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Clinical Oncology2014，5，3： | 7 |
| 3 | 基于U-Net神经网络的多模态MR颈动脉血管成像的分割方法研究显示文摘目的 探讨基于U-Net神经网络的多模态MR影像颈动脉血管分割方法的价值.方法 回顾性分析了2012年至2015年中国动脉粥样硬化风险评估研究项目中,经标准多模态MR扫描,且两周内出现缺血性脑卒中或短暂性脑缺血的患者.经纳入标准和排除标准筛选后,有658例患者共17 568层颈动脉血管壁影像纳入研究.应用定制设计的心血管疾病评估计算机辅助系统(CASCADE,华盛顿大学血管成像实验室,西雅图)对所有影像数据进行分析.按照训练集、验证集和测试集6∶2∶2的比例,随机选取10 592个样本作为训练集,3 488个样本作为验证集,3 488个样本作为测试集.为防止模型过拟合,提高模型泛化能力,对原始的多模态血管斑块MR影像进行数据增强.应用经过微调的U-Net神经网络构建多模态MR影像颈动脉血管分割模型,在训练集上训练,在验证集上验证并优化训练超参数,在测试集上测试并计算像素级别的颈动脉血管分割的敏感度、特异度和Dice系数,并计算U-Net分割方法和手工分割方法下的最大管壁厚度和管壁面积,利用组内相关系数和Bland-Altman分析来验证两种方法的一致性.结果 在测试集上应用训练得到的U-Net神经网络模型进行颈动脉血管分割,计算敏感度为0.878,特异度为0.986,Dice系数为0.858.最大管壁厚度的组内相关系数(95%可信区间)为0.921(0.915~0.925),管壁面积的组内相关系数(95%可信区间)为0.929 (0.924~0.933),Bland-Altman分析中最大管壁厚度差值为(0.037±0.316)mm,管壁面积差值为(1.182± 4.953)mm2,U-Net分割方法和手工分割方法具有较高一致性.结论 应用U-Net神经网络的方法,在大规模经过专业医师标注的数据集上进行训练和验证,可以实现对多模态MR影像颈动脉血管自动分割. | 李继凡 陈硕 章强 宋焱 Gador Canton 孙杰 许东翔 赵锡海 苑纯 李睿 | 2019 | 中华放射学杂志2019，53，12： | 7 |
| 4 | MODELING OF CONTROLLED THERMO-MECHANICAL PROCESSING OF TUBES FOR ENHANCED MANUFACTURING AND PERFORMANCE显示文摘An integrated mathematical model to simulate seamless tube rolling processes has been developed at The Timken Company. The model is capable of simulating the thermal, deformation and microstructure evolution in the piercing, elongating and reducing/sizing and the austenite decomposition in the mill annealing and cooling operations. Finite difference schemes are employed to model cooling, reducing/sizing and stretch reducing, and finite-element schemes are employed to simulate piercing and elongating. The model predicts the thermal history, deformation, rolling load, torque, recrystallization and grain growth in hot tube rolling, austenite decomposition in cooling or annealing, and the final structure-properties. In this paper mathematical models which are employed to describe the thermal, deformation and microstructure evolution along with the modeling results are presented. The developed 'tube rolling mill in the computer' provides a powerful tool for engineers for product and process development, process control, process optimization and quality control. | D. Jin E. D. Dominik R. V. Kolarik II J. E. Ives and E. B. Damm (The Timken Company, 1835 Dueber Avenue, S.W., Canton, Ohio 44706-0932, U.S.A.) | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 5 |
| 5 | Epidemiology of extended-spectrum beta-lactamase-producing Enterobacter isolates in a Spanish hospital during a 12-year period 显示文摘 | Canton R Oliver A Coque T M | 2002 | J Clin Microbiol2002，40，： | 3 |
| 6 | 合成氨工业催化剂的一种新型前躯体—维氏体显示文摘关于合成氨铁系催化剂最佳氧化态前躯体相矛盾的实验结果推动了当前以维氏体和磁铁矿为母体的催化剂的比较研究。测定了两种催化剂的许多物理性质(密度、孔结构、晶相、还原速率、金属表面、磨耗量)和催化性能(动力学常数、耐热性)。证明了以维氏体为母体的催化剂具有更高的活性,尤其是在低温下,除了在高转化率情况下之外,可以达到Ru/C催化剂的性能。本文讨论了以维氏体为母体的催化剂具有这种特性的可能原因,并且建议有必要对合成氨铁系催化剂现有统一的理论知识进行重新考虑。 | N. Pernicone F. Ferrero I. Rossetti L. Forni P. Canton P. Riello G. Fagherazzi M. Signoretto F. Pinna | 2004 | 浙江工业大学学报2004，32，2： | 3 |
| 7 | Quantitative structure-activity relationships and mixture-toxicity studies of alcohols and chlorohydrocarbons: reproducibility of effects on growth and reproduction of Daphnia magna 显示文摘 | Wolf De W Canton J H Deneer J W | 1988 | Aquatic Toxicology1988，12，1： | 1 |
| 8 | Comparison of the susceptibility of 22 freshwater species to 15 chemicalcompounds Ⅰ(sub) acute toxicity tests显示文摘 | Sloof W Canton JH Hermens JLM | 1983 | Aquatic Toxicol1983，，4： | 1 |
| 9 | Inhibition and introduction of aromatase activity by brominated flame retardants in H295 human adrenocortical carcinoma cells 显示文摘 | Canton R F Sanderson J T Letcher R J | 2005 | Toxicological Sciences2005，88，2： | 1 |
| 10 | Candidemia at a tertiary-care hospital: epidemiology, treatment, clinical outcome and risk factors for death 显示文摘 | Viudes A Peman J Canton E | 2002 | Eur J Clin Microbiol Infect Dis2002，21，： | 1 |
| 11 | Nationwide study of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum beta-lactamases in Spain 显示文摘 | Hernandez JR Martinez-Martinez L Canton R | 2005 | Antimicrob Agents Chemother2005，49，5： | 1 |
| 12 | Hemodynamic changes due to stent placement in bifurcating intracranial aneurysms 显示文摘 | Canton G Levy DI Lasheras JC | 2005 | J Neurosurg2005，103，1： | 1 |
| 13 | Selenium sediment toxicity thresholds and derivation of water quality criteria for freshwater biota of western显示文摘 | Van Derveer WD Canton SP | 1997 | Environ Toxicol Chem1997，16，： | 1 |
| 14 | Joint effects of a mixture of 14chemicals on mortality an inhibition of reproduction of Daphnia magna 显示文摘 | Hermens J Canton H Steyger N | 1984 | Aquatic Toxicology1984，4，： | 1 |
| 15 | Clinical applications of growth factors in bone injuries:experience with BMPs显示文摘 | Ronga M Fagetti A Canton G | 2013 | Injury2013，44，1： | 1 |
| 16 | Influence of particle size and crystal orientation on the electrochemical behavior of carbon-coated LiFePO4 显示文摘 | FERRAR1 S LAVALL R L CAPAONI D QUARTARONE E MAGISTRIS A MUSTARELLI P CANTON P | 2010 | J Phys Chem C2010，114，12： | 1 |
| 17 | Long -term exposure of European flounder (Platichthys flesus) to the flame-retardants tetrabromobisphenol A (TBBPA) and hexabromocyclododecane (HBCD) 显示文摘 | Kuiper R V Canton R F Leonards P E G | 2007 | Ecotoxicol Environ Saf2007，67，3： | 1 |
| 18 | Functional changes in the aging kidney 显示文摘 | Esposito C Dal Canton A | 2010 | J Nephrol2010，23，15： | 1 |
| 19 | Spray depoxit sampling technique to evaluate electrostatic aerial spray-charging显示文摘 | CANTON J B BOUSE L F | 1978 | ASAE1978，21，1： | 1 |
| 20 | Efficient encapsulation of plasmid DNA in pH-sensitive PMPC-PDPA polymersomes:study of the effect of pdpa block length on copolymer-dna binding affinity显示文摘 | Lomas H Du JZ Canton I | 2010 | Macromolecular Bioscience2010，10，5： | 1 |
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