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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Effects of intrathecal bupi- vaeaine and bupivacaine plus sufentanil in elderly patients un- dergoing transurethralresection显示文摘 | Doger C YUksel BE Canoler O | 2014 | Niger J Clin Pract2014，17，2： | 1 |
| 3 | A review of malignant meningiomas: diagnosis, characteristics and treatment 显示文摘 | Hanft S Canoll P Bruce JN | 2010 | J Neurooncol2010，99，： | 1 |
| 4 | Cancer-testis and melanocyte-differentiation antigen expression in malignant glioma and meningioma显示文摘 | Omar N. Syed Christopher E. Mandigo Brendan D. Killory Peter Canoll Jeffrey N. Bruce | 2011 | Journal of Clinical Neuroscience2011，，7： | 1 |
| 5 | Differential regulation by pro- tein kinases of activity and cell surface expression of glutamate trans- porters in neuron-enriched cultures 显示文摘 | Guillet BA Velly LJ Canolle B | 2005 | Neurochem Int2005，46，： | 1 |
| 6 | Synchronization in chaotic system显示文摘 | PECORA L M CANOLL T L | 1990 | Physical Review Letters1990，64，8： | 1 |
| 7 | Selective destruction of glioblastoma cells by interference with the activity or expression of ATF5显示文摘 | Angelastro JM Canoll PD Kuo J | 2006 | Oncogene2006，25，6： | 1 |
| 8 | The Determinants of Executive Salaries:A Econometric Survey显示文摘 | Ciscell D H Canoll T M | | 0，，61： | 1 |
| 9 | GGF/neuregulin induces a phenotypic reversion of oligodendrocytes 显示文摘 | Canoll P D Kraemer R Teng K K | 1999 | Mol Cell Neurosci1999，13，2： | 1 |
| 10 | Synchronization in chaotic system显示文摘 | Pecora L M Canoll T L | 1990 | Physical Review Letters1990，64，8： | 1 |
| 11 | GGF/neuregulin induces a phenotypic reversion of oligodendrocytes显示文摘 | Canoll P Kreamer R Teng K | 1999 | Mol Cell Neurosci1999，13，： | 1 |
| 12 | Interferon beta adennoviral gene therapy in a patient with ovarian cancer显示文摘 | Sterman DH Gillespie CT Canoll RG | 2006 | Nat Clin Pract Oncol2006，3，11： | 1 |
| 13 | Assessing the quality of reports of randomized clinical trials is blinding necessary 显示文摘 | Jadad AR Moore RA Canoll D | 1996 | Control Clin Trials1996，17，1： | 1 |
| 14 | GGF/neuregulin is a neuronal signal that promotes the proliferation and sur,ival and inhibits the differentiation of oligodendrocyte progenitors显示文摘 | Canoll P Musachio J Hardy R | 1996 | Neuron1996，17，： | 1 |
| 15 | A review of malignant meningiomas: diagnosis, characteristics, and treatment显示文摘 | Hanft S Canoll P Bruce JN | 2010 | J Neurooncol2010，99，： | 1 |
| 16 | The modified mixture theory for fluid-saturated porous material: theory显示文摘 | KATSUBE N CANOLL M M | 1987 | J Appl Mech1987，54，： | 1 |
| 17 | Cloning of neurotrimin de fines a new subfamily of differentially expressed neural cell adhesion molecules显示文摘 | Struyk AF Canoll PD Wolfgang MJ | 1995 | J Neurosci1995，15，3： | 1 |
| 18 | Selective destruction of glioblastoma cells by interference with the activity or expression of ATF5 显示文摘 | Angelastro JM Canoll PD Kuo J | 2006 | Oncogene2006，，25： | 1 |
| 19 | Synchronization in chaotic system显示文摘 | PECORA L M CANOLL T L | 1990 | Physical Review Letters1990，64，8： | 1 |
| 20 | Selective destruction of glioblastoma cells by interference with the activity or expres?sion of ATF5显示文摘 | AngelastroJ M Canoll P D KuoJ | 2006 | Qncogene2006，25，6： | 1 |
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