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| 1 | Heavy Metal Transfer from Soil to Vegetable in Southern Jiangsu Province, China显示文摘Vegetable fields in peri-urban areas receive large amounts of extraneous heavy metals because of rapid urbanization and industrialization in China. The concentrations of Cu, Zn, and Pb in 30 soil samples and 32 vegetable samples, collected from 30 different sites in southern Jiangsu Province of China, were measured and their transfer from soil to vegetable was determined. The results showed that the soil samples had wide ranges of pH (4.25–7.85) and electrical conductivity (EC) (0.24–3.42 dS m-1). Among the soil samples, there were four soil samples containing higher Cu and two soil samples containing higher Zn concentrations than those specified in the Chinese Soil Environmental Quality Standard II. However, no vegetable sample was found to contain a high level of Cu or Zn. In contrast, one vegetable sample contained 0.243 mg Pb kg-1 FW, which was above the Chinese Food Hygiene Standard, whereas the corresponding soil Pb concentration was lower than the Chinese Soil Environmental Quality Standard II. The transfer coefficients of Cu of all vegetable samples exceeded the suggested coefficient range, implying that extraneous Cu had high mobility and bioavailability to vegetables. There was no significant correlation between extractable soil heavy metal concentrations with four kinds of extractants and soil pH, EC, heavy metal concentrations in vegetables and soils, except that soil pH correlated well with the extractable soil Cu, Zn, and Pb concentrations with 1.0 mol L-1 NH4NO3. Moreover, diethylenetriamine pentaacetic acid (DTPA) extraction method was a more effcient method of extracting heavy metals from the soils independent of soil pH and EC than other three methods used. | HAO Xiu-Zhen ZHOU Dong-Mei HUANG De-Qian CANG Long ZHANG Hai-Lin WANG Hui | 2009 | Pedosphere2009，19，3： | 46 |
| 2 | Marsdenia tenacissima extract induces G_0/G_1 cell cycle arrest in human esophageal carcinoma cells by inhibiting mitogen-activated protein kinase(MAPK) signaling pathway显示文摘Marsdenia tenacissima extract(MTE, trade name: Xiao-Ai-Ping injection) is an extract of a single Chinese plant medicine. It has been used for the treatment of cancer in China for decades, especially for esophageal cancer and other cancers in the digestive tract. In the present study, the potential mechanism for MTE's activity in esophageal cancer was explored. The effects of MTE on the proliferation of human esophageal cancer cells(KYSE150 and Eca-109) were investigated by the MTT assay, the Brd U(bromodeoxyuridine) incorporation immunofluorescence assay, and flow cytometric analysis. MTE inhibited cell proliferation through inducing G0/G1 cell cycle arrest in KYSE150 and Eca-109. Western blot analysis was employed to determine protein levels in the MTE treated cells. Compared with the control cells, the expression levels of the cell cycle regulatory proteins cyclin D1/D2/D3, cyclin E1, CDK2/4/6(CDK: cyclin dependent kinase), and p-Rb were decreased significantly in the cells treated with MTE at 40 mg·m L-1. In addition, MTE had an inhibitory effect on the MAPK(mitogen-activated protein kinase) signal transduction pathway, including ERK(extracellular signal-regulated kinase), JNK(c-Jun N-terminal kinase), and p38 MAPK. Moreover, MTE showed little additional effects on the regulation of cyclin D1/D3, CDK4/6, and p-Rb when the ERK pathway was already inhibited by the specific ERK inhibitor U0126. In conclusion, these data suggest that MTE inhibits human esophageal cancer cell proliferation through regulation of cell cycle regulatory proteins and the MAPK signaling pathways, which is probably mediated by the inhibition of ERK activation. | FAN Wei SUN Li ZHOU Jing-Qian ZHANG Cang QIN Song TANG Ying LIU Yang LIN Sen-Sen YUAN Sheng-Tao | 2015 | Chinese Journal of Natural Medicines2015，13，6： | 32 |
| 3 | Gene expression alteration during redox-dependent enhancement of arsenic cytotoxicity by emodin in HeLa cells显示文摘Emodin (1,3,8-trihydroxy-6-methylanthraquinone) could enhance the sensitivity of tumor cells to arsenic trioxide(As2O3)–induced apoptosis via generation of ROS, but the molecular mechanism has not been elucidated. Here, wecarried out cDNA microarray-based global transcription profiling of HeLa cells in response to As2O3/emodin cotreatment,comparing with As2O3–only treatment. The results showed that the expression of a number of genes was substantiallyaltered at two time points. These genes are involved in different aspects of cell function. In addition to redox regulationand apoptosis, ROS affect genes encoding proteins associated with cell signaling, organelle functions, cell cycle,cytoskeleton, etc. These data suggest that based on the cytotoxicity of As2O3, emodin mobilize every genomic resourcethrough which the As2O3–induced apoptosis is facilitated. | Xiao Jing WANG Jie YANG Hui CANG Yan Qiong ZOU Jing YI | 2005 | Cell Research2005，15，7： | 28 |
| 4 | Mechanism of exosomal microRNA-224 in development of hepatocellular carcinoma and its diagnostic and prognostic value显示文摘BACKGROUND Exosomes contain proteins, lipids, and biological molecules such as DNA and RNA. Nucleic acids in exosomes are a group of molecules that can act as biomarkers. Currently, there are many reports on exosomal microRNAs, which are ideal biomarkers for the early diagnosis of cancer. However, there are few reports on the role of exosomal microRNAs in the diagnosis and prognosis of hepatocellular carcinoma(HCC).AIM To understand the mechanism of exosomal microRNA-224(miR-224) in the development of HCC and evaluate its diagnostic and prognostic value.METHODS Cell culture and transfection of exosomal miRNA-224, real-time quantitative PCR, luciferase reporter assay, and other methods were used to find new biomarkers related to the development of HCC that can be used to diagnose HCC and predict HCC prognosis.RESULTSBy targeting glycine N-methyltransferase, incubating exosomes with miR-224 mimic resulted in a significant increase in cell proliferation compared to that of the control group, while incubation with the miR-224 inhibitor significantly reduced cell proliferation. The same results were obtained for the cell invasion assay. Serum exosomal miR-224 did have some ability to differentiate patients with HCC from healthy controls, with an area under the curve of 0.910, and HCC patients with higher serum exosomal miR-224 expression had lower overall survival.CONCLUSION Exosomal miR-224 is a tumor promotor and can be a marker of diagnosis and prognosis of HCC patients, however, its ability to distinguish liver diseases needs further verification. | Yao Cui Hai-Feng Xu Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Interventional Therapy Department Peking University Cancer Hospital and Institute Ming-Yue Liu Yu-Jie Xu Jun-Chuang He Yun Zhou Shun-Dong Cang | 2019 | World Journal of Gastroenterology2019，25，15： | 26 |
| 5 | A Brief Overview of Low CO_2 Emission Technologies forIron and Steel Making显示文摘The global steel production has been growing for the last 50 years,from 200Mt in 1950s to 1240Mt in 2006. Iron and steel making industry is one of the most energy-intensive industries,with an annual energy consumption of about 24 EJ,5% of the world's total energy consumption. The steel industry accounts for 3%-4% of total world greenhouse gas emissions. Enhancing energy efficiency and employing energy saving/recovering technologies such as coke dry quechning (CDQ) and top pressure recovery turbine (TRT) can be short-term approaches to the steel industry to reduce greenhouse gas emission. The long-term approaches to achieving a significant reduction in CO2 emissions from the steel industry would be through developing and applying CO2 breakthrough technologies for iron and steel making,and through increasing use of renewable energy for iron and steel making. Thus,an overview of new CO2 breakthrough technologies for iron and steel making was made. | Chunbao (Charles) XU CANG Da-qiang | 2010 | Journal of Iron and Steel Research(International)2010，17，3： | 22 |
| 6 | p16 gene methylation in colorectal cancers associated with Duke's staging显示文摘AIM To explore the association of methylation of the CpG island in the promotor of the p16 tumor suppressor gene with the clinicopathological characteristics of the colorectal cancers.``METHODS Methylation-specific PCR (MSP) was used to detect p16 methylation of 62 sporadic colorectal cancer specimens.``RESULTS pi6 methylation was detected in 42% of the tumors. Dukes staging was associated with p16methylation status, p16 methylation occurred more frequently in Dukes C and D patients (75.9%) than in Dukes A and B patients (12.1%).``CONCLUSION p16 rnethylation plays a role in the carcinogenesis of a subset of colorectal cancer, and it might be linked to poor prognosis. | Jing Yi~1 Zhi-Wei Wang~1 Hui Cang~1 Yu-Ying Chen~1 Ren Zhao~2 Bao-Ming Yu~2 Xue-Ming Tang~1 1 Department of Cell Biology,2 Department of Surgery,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China | 2001 | World Journal of Gastroenterology2001，7，5： | 21 |
| 7 | Sevoflurane exposure in 7-day-old rats affects neurogenesis, neurodegeneration and neurocognitive function显示文摘Objective Sevoflurane is widely used in pediatric anesthesia and former studies showed that it causes neurodegeneration in the developing brain. The present study was carried out to investigate the effects of sevoflurane on neurogenesis, neurodegeneration and behavior. Methods We administered 5-bromodeoxyuridine, an S-phase marker, before, during, and after 4 h of sevoflurane given to rats on postnatal day 7 to assess dentate gyrus progenitor proliferation and Fluoro-Jade staining for degeneration. Spatial reference memory was tested 2 and 6 weeks after anesthesia. Results Sevoflurane decreased progenitor proliferation and increased cell death until at least 4 days after anesthesia. Spatial reference memory was not affected at 2 weeks but was affected at 6 weeks after sevoflurane administration. Conclusion Sevoflurane reduces neurogenesis and increases the death of progenitor cells in developing brain. This might mediate the lateonset neurocognitive outcome after sevoflurane application. | Fang Fang Zhanggang Xue Jing Cang | 2012 | Neuroscience Bulletin2012，28，5： | 12 |
| 8 | Thermodynamic analysis and formula optimization of steel slag-based ceramic materials by FACTsage software显示文摘Using steel slag as a main raw material of ceramics is considered as a high value-added way. However, the relationship among the initial composition, ceramic microstructure, and macroscopic properties requires further study. In this paper, a series of ceramics with different slag ratios (0-70wt%) were designed, and the software FACTsage was introduced to simulate the formation of crystalline phases. The simulation results indicate that mullite is generated but drastically reduced at the slag ratios of 0-25wt%, and anorthite is the dominant crystalline phase in the slag content of 25wt%-45wt%. When the slag ratio is above 45wt%, pyroxene is generated more than anorthite. This is because increasing magnesium can promote the formation of pyroxene. Then, the formula with a slag content of 40wt% was selected and optimized. X-ray diffraction results were good consistent with the simulation results. Finally, the water absorption and bending strength of optimized samples were measured. | Xian-bin Ai Hao Bai Li-hua Zhao Da-qiang Cang Qi Tang | 2013 | International Journal of Minerals,Metallurgy and Materials2013，20，4： | 12 |
| 9 | Effect of Different Amendments on Ryegrass Growth in Copper Mine Tailings显示文摘Montmorillonite, rice straw, organic manure and chemical fertilizer were used as amendment materials for copper mine tailings, and their effects on mine tailing pH, nutrients and metal availability to ryegrass were investigated. Chemical fertilization was the most effective one in improving ryegrass growth in mine tailings among the amendment materials examined. It was found that montmorillonite raised biomass of ryegrass at the 1st and 2nd cuts, but it did not give further positive effects at the 3rd and 4th cuts. The effect of organic materials on ryegrass growth was not so good as expected, mainly due to their slow decomposition in mine tailings with less soil microorganisms. Available Cu and Zn contents in mine tailings decreased in the presence of montmorillonite but increased when rice straw and organic manure were used as amendments. Cu and Zn contents in ryegrass decreased with increasing the rate of montmorillonite application but increased with the rate of rice straw. Zn showed much stronger mobility from soil to ryegrass than Cu, and almost all the available N and P in mine tailings, except for the treatments with organic manure, were completely consumed after ryegrass had grown in mine tailings for more than four months and been harvested for four times. Owing to its large biomass and high metal uptake, ryegrass is a potential plant for remediation of metal contaminated soils in practice. | HAO Xiu-Zhen, ZHOU Dong-Mei, WANG Yu-Jun, CANG Long and CHEN Huai-ManInstitute of Soil Science, the Chinese Academy of Sciences, Nanjing 210008 (China). E-mail: xzhao@issas. ac.cn | 2003 | Pedosphere2003，13，4： | 11 |
| 10 | Relationship between gene expression and the accumulation of catechin during spring and autumn in tea plants (Camellia sinensis L.)显示文摘The tea plant(Camellia sinensis L.)is an important commercial crop with remarkably high catechin concentrations.Tea is popular worldwide given the plant's health benefits.Catechins are the main astringent substance in tea and are synthesized mainly via the phenylpropanoid pathway.In this study,eight cultivars of tea plants harvested both in spring and autumn were used to investigate differences in catechin concentrations by using high-performance liquid chromatography.The expression levels of genes associated with catechin biosynthesis were investigated using reverse transcription-quantitative polymerase chain reaction.The results indicated that the total catechin(TC)concentrations were significantly higher in tea plants harvested in autumn than in those harvested in spring,based on higher concentrations of epigallocatechin(EGC)in autumn tea(P<0.01).The expression of the genes phenylalanine ammonia-lyase(PAL),flavanone 3-hydroxylase(F3H),flavonoid 3′,5′-hydroxylase(F3′5′H),dihydroflavonol 4-reductase(DFR),and anthocyanidin synthase(ANS)is closely related to the TC content of tea plants in both spring and autumn.Positive correlations between PAL,cinnamate 4-hydroxylase(C4H),F3H,and DFR expression and EGC accumulation in autumn tea were identified,with correlation coefficients of 0.710,0.763,0.884,and 0.707,respectively.A negative correlation between ANS expression level and EGC concentrations in tea plants harvested in spring was noted(r=−0.732).Additionally,negative correlations between F3H and ANS expression levels and the catechin content were identified in spring tea,whereas the correlations were positive in autumn tea.Significant differences in the F3H and ANS expression levels between spring and autumn tea indicate that F3H and ANS are potentially key genes affecting catechin accumulation in tea plants. | Min Liu Heng-lu Tian Jian-Hua Wu Ren-Rong Cang Run-Xian Wang Xiao-Hua Qi Qiang Xu Xue-Hao Chen | 2015 | Horticulture Research2015，2，1： | 10 |
| 11 | Knockdown of HMGB1 improves apoptosis and suppresses proliferation and invasion of glioma cells显示文摘Background: Effective methods for managing patients with solitary pulmonary nodules(SPNs) depend critically on the predictive probability of malignancy.Methods: Between July 2009 and June 2011, data on gender, age, cancer history, tumor familial history, smoking status, tumor location, nodule size, spiculation, calcification, the tumor border, and the final pathological diagnosis were collected retrospectively from 154 surgical patients with an SPN measuring 3-30 mm. Each final diagnosis was compared with the probability calculated by three predicted models—the Mayo, VA, and Peking University(PU) models. The accuracy of each model was assessed using area under the receiver operating characteristics(ROC) and calibration curves.Results: The area under the ROC curve of the PU model [0.800; 95% confidence interval(CI): 0.708-0.891] was higher than that of the Mayo model(0.753; 95% CI: 0.650-0.857) or VA model(0.728; 95% CI: 0.623-0.833); however, this finding was not statistically significant. To varying degrees, calibration curves showed that all three models overestimated malignancy.Conclusions: The three predicted models have similar accuracy for prediction of SPN malignancy, although the accuracy is not sufficient. For Chinese patients, the PU model may has greater predictive power.Background: Here, we introduced our short experience on the application of a new CUSA Excel ultrasonic aspiration system, which was provided by Integra Lifesciences corporation, in skull base meningiomas resection.Methods: Ten patients with anterior, middle skull base and sphenoid ridge meningioma were operated using the CUSA Excel ultrasonic aspiration system at the Neurosurgery Department of Shanghai Huashan Hospital from August 2014 to October 2014. There were six male and four female patients, aged from 38 to 61 years old(the mean age was 48.5 years old). Five cases with tumor located at anterior skull base, three cases with tumor on middle skull base, and two cases with tumor on sphenoid ridge.Results: All the patents received total resection of meningiomas with the help of this new tool, and the critical brain vessels and nerves were preserved during operations. All the patients recovered well after operation.Conclusions: This new CUSA Excel ultrasonic aspiration system has the advantage of preserving vital brain arteries and cranial nerves during skull base meningioma resection, which is very important for skull base tumor operations. This key step would ensure a well prognosis for patients. We hope the neurosurgeons would benefit from this kind of technique.Background: The purposes of this study were to explore the effects of high mobility group protein box 1(HMGB1) gene on the growth, proliferation, apoptosis, invasion, and metastasis of glioma cells, with an attempt to provide potential therapeutic targets for the treatment of glioma. Methods: The expressions of HMGB1 in glioma cells(U251, U-87 MG and LN-18) and one control cell line(SVG p12) were detected by real time PCR and Western blotting, respectively. Then, the effects of HMGB1 on the biological behaviors of glioma cells were detected: the expression of HMGB1 in human glioma cell lines U251 and U-87 MG were suppressed using RNAi technique, then the influences of HMGB1 on the viability, cycle, apoptosis, and invasion abilities of U251 and U-87 MG cells were analyzed using in a Transwell invasion chamber. Also, the effects of HMGB1 on the expressions of cyclin D1, Bax, Bcl-2, and MMP 9 were detected. Results: As shown by real-time PCR and Western blotting, the expression of HMGB1 significantly increased in glioma cells(U251, U-87 MG, and LN-18) in comparison with the control cell line(SVG p12); the vitality, proliferation and invasive capabilities of U251 and U-87 MG cells in the HMGB1 siR NA-transfected group were significantly lower than those in the blank control group and negative control(NC) siR NA group(P<0.05) but showed no significant difference between the blank control group and NC siR NA group. The percentage of apoptotic U251 and U-87 MG cells was significantly higher in the HMGB1 siR NA-transfected group than in the blank control group and NC siR NA group(P<0.05) but was similar between the latter two groups. The HMGB1 siR NA-transfected group had significantly lower expression levels of Cyclin D1, Bcl-2, and MMP-9 protein in U251 and U-87 MG cells and significantly higher expression of Bax protein than in the blank control group and NC siR NA group(P<0.05); the expression profiles of cyclin D1, Bax, Bcl-2, and MMP 9 showed no significant change in both blank control group and NC siR NA group. Conclusions: HMGB1 gene may promote the proliferation and migration of glioma cells and suppress its effects of apoptosis. Inhibition of the expression of HMGB1 gene can suppress the proliferation and migration of glioma cells and promote their apoptosis. Our observations provided a new target for intervention and treatment of glioma. | Jing Zhang Cang Liu Ruiguang Hou | 2014 | Chinese Journal of Cancer Research2014，26，6： | 9 |
| 12 | Viral and Bacterial Etiology of Acute Febrile Respiratory Syndrome among Patients in Qinghai, China显示文摘Objective This study was conducted to investigate the viral and bacterial etiology and epidemiology of patients with acute febrile respiratory syndrome(AFRS) in Qinghai using a commercial routine multiplex-ligation-nucleic acid amplification test(NAT)-based assay. Methods A total of 445 nasopharyngeal swabs specimens from patients with AFRS were analyzed using the RespiFinderSmart22 kit(PathoFinder BV, Netherlands) and the LightCycler 480 real-time PCR system. Results Among the 225(225/445, 51%) positive specimens, 329 positive pathogens were detected, including 298(90.58%) viruses and 31(9%) bacteria. The most commonly detected pathogens were influenza virus(IFV;37.39%;123/329), adenovirus(AdV;17.02%;56/329), human coronaviruses(HCoVs;10.94%;36/329), rhinovirus/enterovirus(RV/EV;10.03%;33/329), parainfluenza viruses(PIVs;8.51%;28/329), and Mycoplasma pneumoniae(M. pneu;8.51%;28/329), respectively. Among the co-infected cases(17.53%;78/445), IFV/AdV and IFV/M. pneu were the most common co-infections. Most of the respiratory viruses were detected in summer and fall. Conclusion In our study, IFV-A was the most common respiratory pathogen among 22 detected pathogens, followed by AdV, HCoV, RV/EV, PIV, and M. pneu. Bacteria appeared less frequently than viruses, and co-infection was the most common phenomenon among viral pathogens. Pathogens were distributed among different age groups and respiratory viruses were generally active in July, September, and November. Enhanced surveillance and early detection can be useful in the diagnosis, treatment, and prevention of AFRS, as well as for guiding the development of appropriate public health strategies. | LIU Gao Shan LI Hong ZHAO Sheng Cang LU Rou Jian NIU Pei Hua TAN Wen Jie | 2019 | Biomedical and Environmental Sciences2019，32，6： | 8 |
| 13 | The biphasic redox sensing of SENP3 accounts for the HIF-1 transcriptional activity shift by oxidative stress显示文摘目的: 在氧化应力的不同层次下面的 transcriptional 活动由反应氧化种类(ROS ) 引起了调查位于组织缺氧可诱导的 factor-1 (HIF-1 ) 的 biphasic 氧化还原作用规定下面的机制。 | Ying WANG Jie YANG Kai YANG Hui CANG Xin-zhi HUANG Hui LI Jing YI | 2012 | Acta Pharmacologica Sinica2012，33，7： | 8 |
| 14 | Validation of surface coating with nanoparticles to improve the flowability of fine cohesive powders显示文摘 | Xiaolin Zhu Qiang Zhang Cang Huang Yao Wang Chaohe Yang Fei Wei | 2017 | Particuology2017，15，1： | 7 |
| 15 | Long Campaign of BF with Overheating-Free Cooling Stave显示文摘A basic idea of permanent lining in designing long campaign of BF was put forward. BF designer should follow a chain of thinking procedure: Cooling water-Cooling system-Refractory lining. The temperature field of BF wall and cooling stave was calculated using heat transfer model and the results were proved by a 1 000-1 200 ℃ test rig. The overheating-free cooling stave with different parameters was designed, and such a long campaign of BF (15 years) was going to put into construction. | CHENG Su sen YANG Tian jun CANG Da qiang | 2003 | Journal of Iron and Steel Research(International)2003，10，3： | 7 |
| 16 | Free Cu^(2+) Ions,Cu Fractionation and Microbial Parameters in Soils from Apple Orchards Following Long-Term Application of Copper Fungicides显示文摘Soil samples were collected from apple orchards 5,15,20,30,and 45 years old,and one adjacent forest soil was used as reference to investigate the free Cu2+ion activity in soil solution and the soil Cu fractionation in the solid phase following long-term application of copper fungicide,Bordeaux mixture,in apple orchards and to investigate the relationships among soil free Cu2+ions,Cu fractionation and soil microbial parameters.The total Cu concentration in the orchard soils varied from 21.8 to 141 mg kg-1,increasing with the orchard age,and the value for the reference soil was 12.5 mg kg-1.The free Cu2+ion concentrations in the soil solutions extracted by 0.01 mol L-1 KNO3 ranged from 3.13×10-8(reference)to 4.08×10-6 mol L-1(45 years-old orchard).The concentration of Cu complexed in the fulvic fraction increased with orchard age from 5.16 to 52.5 mg kg-1.This was also the case for other soil Cu fractions except the residual one.The residual soil Cu remained practically constant,ranging from 4.28 to 5.66 mg kg-1,suggesting that anthropogenic soil Cu mainly existed in the more labile active fractions.Regression analyses revealed that both the free Cu2+ions in the soil solution and the humic acid-complexed Cu fraction in the solid phase were strongly related with soil microbial parameters. | ZHOU Dong-Mei WANG Quan-Ying CANG Long | 2011 | Pedosphere2011，21，2： | 7 |
| 17 | Complementation in the composition of steel slag and red mud for preparation of novel ceramics显示文摘A method for preparing novel ceramics was developed in this study. Different ratios red muds were added to steel slags to optimize the preparation of novel ceramics by a traditional ceramic preparation process. The sintering mechanism, microstructure, and performance were studied by X-ray diffraction techniques, scanning electron microscopy, and combined experiments of linear shrinkage, water absorption, and flexural strength. The results confirmed that red mud can reduce the volumetric instabilities through the complementarity of red mud and ferroalloy slag. The crystal phases in the ceramics are all pyroxene group minerals, including diopside ferrian, augite, and diopside. The flexural strength of the ceramic that contains 40 wt% red mud and was prepared at the optimal sintering temperature(1140°C) is greater than 93 MPa; its corresponding water absorption is less than 0.05%. | Yan-bing Zong Wen-hui Chen Yong Fan Tai-lin Yang Zhao-bo Liu Da-qiang Cang | 2018 | International Journal of Minerals,Metallurgy and Materials2018，25，9： | 7 |
| 18 | Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1显示文摘细胞内部的反应的氧种类(ROS ) 被知道调整 apoptosis。caspase-9 的激活,在 mitochondrial apoptotic 串联的起始的 caspase,仔细与被联系 ROS,而是它是不清楚的是否 ROS 经由直接氧化的修正调整 caspase-9。阐明的现在的学习目的由哪个 ROS 调停的分子的机制 caspase-9 激活。我们的结果证明细胞的氧化状态便于 caspase-9 激活。氢过氧化物治疗引起 caspase-9 和 apoptosis 的激活,并且支持在 caspase-9 和 apoptotic 之间的一个相互作用激活朊酶的因素 1 (Apaf-1 ) 经由二硫化物形成。另外,在里面一在里面 vitro 没有线粒体的系统, thiol 氧化剂 diamide 由便于连接二硫化物的建筑群的形成支持 caspase-9 和 caspase-9/Apaf-1 相互作用的汽车劈开。最后,在 caspase-9 的 C403 的一个点变化通过二硫化物形成的废除损害有 Apaf-1 的两支持 H2O2 的 caspase-9 激活和相互作用。在细胞色素 c 和 C403S 异种之间的协会在细胞色素 c 和野类型的 caspase-9 之间是比那显著地弱的,显示 caspase-9 的那氧化修正贡献在氧化应力下面的 apoptosome 形成。一起拿,由 ROS 的 caspase-9 的氧化修正能调停它和 Apaf-1 的相互作用,和罐头因此支持它的汽车劈开和激活。这机制可以在氧化应力下面便于 apoptosome 形成和 caspase-9 激活。 | Yong Zuo Binggang Xiang Jie Yang Xuxu Sun Yumei Wang Hui Cang Jing Yi | 2009 | Cell Research2009，19，4： | 6 |
| 19 | Balanced solubility product and enthalpies of formation of Nb compounds in 0.09 % oriented silicon steel显示文摘Balance solubility products and enthalpy of formation for NbC0.75 , NbC0.85 , NbC0.88 , NbC and NbN in oriented silicon steels were calculated and compared qualitatively. Meanwhile, the mixing enthalpies of these five Nb compounds were calculated based on Miedema Model. The results show that the solubility products of Nb compounds in ferrite and austenite meet the following relationship, NbC0.75>NbC0.85> NbC0.88>NbC>NbN and NbN has the minimum enthalpy of formation. It indicates that NbN easily precipitate out, but it is more difficult for NbC 0.75 . | Hui Li Yun-Li Feng Dan Zhang Meng Song Da-Qiang Cang | 2013 | Rare Metals2013，32，3： | 6 |
| 20 | Cascade effects of crop species richness on the diversity of pest insects and their natural enemies显示文摘Understanding how plant species richness influences the diversity of herbivorous and predatory/parasitic arthropods is central to community ecology.We explore the effects of crop species richness on the diversity of pest insects and their natural enemies.Using data from a four-year experiment with five levels of crop species richness,we found that crop species richness significantly affected the pest species richness,but there were no significant effects on richness of the pests’natural enemies.In contrast,the species richness of pest insects significantly affected their natural enemies.These findings suggest a cascade effect where trophic interactions are strong between adjacent trophic levels,while the interactions between connected but nonadjacent trophic levels are weakened by the intermediate trophic level.High crop species richness resulted in a more stable arthropod community compared with communities in monoculture crops.Our results highlight the complicated cross-trophic interactions and the crucial role of crop diversity in the food webs of agro-ecosystems. | SHI PeiJian HUI Cang MEN XingYuan ZHAO ZiHua OUYANG Fang GE Feng JIN XianShi CAO HaiFeng LI B.Larry | 2014 | Science China(Life Sciences)2014，57，7： | 6 |
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