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| 1 | Current and novel approaches in the pharmacological treatment of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the most lethal malignant tumours worldwide.The mortality-to-incidence ratio is up to 91.6%in many countries,representing the third leading cause of cancer-related deaths.Systemic drugs,including the multikinase inhibitors sorafenib and lenvatinib,are first-line drugs used in HCC treatment.Unfortunately,these therapies are ineffective in most cases due to late diagnosis and the development of tumour resistance.Thus,novel pharmacological alternatives are urgently needed.For instance,immune checkpoint inhibitors have provided new approaches targeting cells of the immune system.Furthermore,monoclonal antibodies against programmed cell death-1 have shown benefits in HCC patients.In addition,drug combinations,including first-line treatment and immunotherapy,as well as drug repurposing,are promising novel therapeutic alternatives.Here,we review the current and novel pharmacological approaches to fight HCC.Preclinical studies,as well as approved and ongoing clinical trials for liver cancer treatment,are discussed.The pharmacological opportunities analysed here should lead to significant improvement in HCC therapy. | Fernanda Villarruel-Melquiades María Eugenia Mendoza-Garrido Claudia M García-Cuellar Yesennia Sánchez-Pérez Julio Isael Pérez-Carreón Javier Camacho | 2023 | World Journal of Gastroenterology2023，29，17： | 2 |
| 2 | The role of social anxiousness in group brainstorming 显示文摘 | Camacho L M & Paulus P B | 1995 | Journal of Personality and Social Psychology1995，，68： | 1 |
| 3 | A simple method for obtaining kinetic equations to describe the enzymatic hydrolysis ofbiopolymers显示文摘 | Gonzalez-Tello P Camacho F Jurado E | 1996 | Biotechnol1996，67，3： | 1 |
| 4 | Reply to T Weishaar显示文摘 | DURAZO- ARVIZU R A CAMACHO P BOVET P | 2015 | Am J Clin Nutr2015，101，2： | 1 |
| 5 | MRI segmentation:methods and applications显示文摘 | Clarke L P Ve1thuizen M R P Camacho A | 1995 | Magnita Resonance Imaging1995，13，3： | 1 |
| 6 | Prediction rule for biogas valorisation in municipal solid waste landfill显示文摘 | Marticorena B Attal A Camacho P | 1993 | Water Sci Technol1993，27，2： | 1 |
| 7 | The origin of cor- relations in metabolomics data显示文摘 | Camacho D De La Fuente A Mendes P | 2005 | Metabolomics2005，1，1： | 1 |
| 8 | Analysis of clear corneal incision integrity in an ex vivo model 显示文摘 | May W Castro-Combs J Camacho W Wittmann P Behrens A | 2008 | J Cataract Refract Surg2008，34，6： | 1 |
| 9 | Pilot study of combination transcriptional modulation therapy with sodium phenylbutyrate and 5-azacytidine in patients with acute myeloid leukemia or myelodysplastic syndrome显示文摘 | Maslak P Chanel S Camacho LH | 2006 | Leukemia2006，20，2： | 1 |
| 10 | Ca^2+ wave dispersion and spiral wave entrainment in Xenopus laevis oocytes overexpressing Ca^2+ ATPases 显示文摘 | Lechleiter J D John L M Camacho P | 1998 | J Biophysical Chemistry1998，72，： | 1 |
| 11 | Minimization of sludge production in biological processes:An alternative solution for the problem of sludge disposal显示文摘 | Camacho P Deleris S Geaugey V | 2002 | Water Science and Technology2002，46，10： | 1 |
| 12 | Measurement of intracellular calcium显示文摘 | Takahashi A Camacho P Lechleiter J D | 1999 | Physiol Rev1999，79，： | 1 |
| 13 | FTIR micro- scopic imaging of collagen and proteoglycan in bovine cartilage显示文摘 | Camacho N P West P Torzilli P A | 2001 | Biopolymers2001，62，1： | 1 |
| 14 | MRI segmentation: methods and applications显示文摘 | Clarke L P Velthuizen R P Camacho M A | 1995 | Magnetic Resonance Imaging1995，13，3： | 1 |
| 15 | Identification and characterization of an amino acid transporter expressed dif- ferentially in liver显示文摘 | GU S RODERICK H L CAMACHO P | 2000 | Proc Natl Acad Sci USA2000，97，7： | 1 |
| 16 | Measurement of intracellular calcium 显示文摘 | Takahashi A Camacho P Lechleiter J D | 1999 | Physiol Rev1999，79，4： | 1 |
| 17 | B-chromosome evo- lution, philosophical transactions of the royal society of London显示文摘 | Camacho J P M Sharbel T F Beukeboom L W | 2000 | Series B : Biological Sciences2000，355，： | 1 |
| 18 | MicroRNA and protein profiling of brain metastasis competent cell-derived exosomes显示文摘 | Camacho L Guerrero P Marchetti D | 2013 | PLoS One2013，8，73： | 1 |
| 19 | Measurement of intracellular calcium显示文摘 | Takahashi A Camacho P Lechleiter JD | 1999 | Physiol Rev1999，79，4： | 1 |
| 20 | Prediction rule for biogas valorisation in municipal solid waste landfill显示文摘 | Marticorena B Attal A Camacho P | | 0，，02： | 1 |
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