|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Lactobacillus bulgaricus inhibits colitis-associated cancer via a negative regulation of intestinal inflammation in azoxymethane/dextran sodium sulfate model显示文摘BACKGROUND Colitis-associated cancer(CAC)accounts for 2%-3%of colorectal cancer(CRC)cases preceded by inflammatory bowel diseases(IBD)such as Crohn's disease and ulcerative colitis.Intestinal microbiota has been reported to play a central role in the pathogenesis of IBD and CAC.Recently,numerous prebiotics and probiotics have being investigated as antitumor agents due to their capacity to modulate inflammatory responses.Previous studies have indicated that lactic acid bacteria could be successfully used in managing sporadic CRC,however little is known about their role in CAC.AIM To investigate the effect of the probiotic Lactobacillus bulgaricus(L.bulgaricus)during the development of an experimental model of colitis associated colon cancer(CAC).METHODS C57BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg),followed by three cycles of sodium dextran sulphate diluted in water(5%w/v).Probiotic group received daily L.bulgaricus.Intestinal inflammation was determined by scoring clinical signs.Cytokines levels were determined from colon and/or tumor samples by ELISA BD OptEIATM kits.The level of significance was set at P<0.05.Graphs were generated and statistical analysis performed using the software GraphPad Prism 6.0.RESULTS L.bulgaricus treatment inhibited of total tumor volume and mean size of tumors.In addition,the probiotic also attenuated the clinical signs of intestinal inflammation inducing a decrease in intestinal and tumor levels of IL-6,TNF-α,IL-17,IL-23 and IL-1β.CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC.L.bulgaricus regulates the inflammatory response and preventing CAC. | Denise Sayuri Calheiros Silveira Luciana Chain Veronez Luis Carlos Lopes-Junior Elen Anatriello Mariangela Ottoboni Brunaldi Gabriela Pereira-da-Silva | 2020 | World Journal of Gastroenterology2020，26，43： | 3 |
| 2 | Therapeutic and biological activities of Calotropis procera(Ait.) R.Br.显示文摘Medicinal plants have been used to treat various ailments of the poor population around the world;hence the interest among researchers to know the active ingredients of certain plants has being increased.The Calotropis procera(C.procera) is a plant original from Africa,commonly found in northeastern Brazil.It is well known for their pharmacological properties,since it produces large amounts of latex.The important role that medicinal plants play in folk medicine has led us to develop this article in order to review the major pharmacological activities of C. procera. | Marcia Calheiros Chaves Silva Antonio Batista da Silva Fabiano Moura Teixeira Paulo Cesar Pereira de Sousa Regina Maria Macedo Rondon Jose Eduardo Ribeiro Honorio Junior Luiz Rafael Leite Sampaio Samanda Lima Oliveira Angela Nadyla Martins Holonda Silvania Maria Mendes de Vasconcelos | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，4： | 2 |
| 3 | Polymeriza- tion contraction stress of low-shrlnkage composites and its correlation with mieroleakage in Class V restorations 显示文摘 | Calheiros FC Sadek b'T Braga RR | 2004 | J Dent2004，32，5： | 1 |
| 4 | CloudSim:a toolkit for modeling and simulation of cloud computing environments and evaluation of resource provisioning algorithms显示文摘 | Calheiros R N Ranjan R Rose CAF D | 2011 | Software:Practice and Experience2011，41，1： | 1 |
| 5 | CloudSim:a toolkit for modeling and simulation of cloud computing environments and evaluation of resource provi- sioning algorithms 显示文摘 | CALHEIROS R N RAN JAN R BELOGLAZOY A | | Practice and Experience0，41，1： | 1 |
| 6 | CloudSim: a toolkit for modeling and simulation of cloud computing environments and evaluation of re- source provisioning algorithms 显示文摘 | CALHEIROS R RANJAN R ANTON B | 2011 | Software: Practice and Experience2011，41，1： | 1 |
| 7 | Bacterial community dynamics in horizontal flow constructed wetlands with different plants for high salinity industrial wastewater polishing显示文摘 | CALHEIROS C S C TEIXEIRA A PIRES C | 2010 | Water Research2010，44，17： | 1 |
| 8 | Polyamines: fundamental characters in chemistry and biology显示文摘 | AGOSTINELLI E MARQUES M P CALHEIROS R | 2010 | Amino Acids2010，38，2： | 1 |
| 9 | CloudSim:a toolkit for modeling and simulation of cloud computing environments and evaluation of resource provisioning algorithms显示文摘 | Calheiros R N Ranjan R Beloglazov A | | 0，，： | 1 |
| 10 | CloudSim: a toolkit for modeling and simulation of cloud computing environ-ments and evaluation of resource provisioning algorithms显示文摘 | CALHEIROS R N RANJAN R BELOGLAZOV A | 2011 | Software Practice and Experience2011，41，1： | 1 |
| 11 | The effects of silver nitrate and different carbohydrate sources on somatic embryogenesis in coffea canephora显示文摘 | Fuentes S L Calheiros M P Manetti-Filho J | 2000 | Plant Cell Tiss Org Cult2000，60，： | 1 |
| 12 | EMUSIM:an integrated emulation and simulation environment for modeling,evaluation,and validation of performance of cloud computing applications显示文摘 | Calheiros R N Netto M A S De Rose C A F | 2013 | Software:Practice and Experience2013，43，5： | 1 |
| 13 | Evaluation of the effi- cacy of deep brain stimulation in the surgical treatment of cervical dystonia显示文摘 | Calheiros --Trigo F Linhares P | 2014 | Neurocirugia2014，，2： | 1 |
| 14 | Cloud- Sim: a toolkit for modeling and simulation of cloud computing environments and evaluate-on of resource provisioning algorithms显示文摘 | Calheiros R N Ranjan R Buyya R | | Software: Practice and Experience0，41，1： | 1 |
| 15 | The effects of silver nitrate and different carbohydrate sources on somatic embryogenesis in Coffea canephora显示文摘 | Fuentes S R L Calheiros M B P Manetti-Filho J Vieira L G E | | 0，，01： | 1 |
| 16 | A new iterative method to compute nonlinear equations显示文摘 | Basto M Semiao V Calheiros F L | 2006 | Applied Mathematics and Computation2006，173，1： | 1 |
| 17 | CloudSim: a toolkit for modeling and simulation of cloud computing environments and evaluation of resource provisioning algorithms 显示文摘 | Calheiros R N Ranjan R Beloglazov A | 2011 | Software: Practice and Experience2011，41，1： | 1 |
| 18 | Polyamines: funda- mental characters in chemistry and biology显示文摘 | Agostinelli E Marques MP Calheiros R | 2010 | Amino Acids2010，38，2： | 1 |
| 19 | Theeffects of silver nitrate and different carbohydrate sources on somatic embryogenesis in Coffea canephora显示文摘 | Fuentes S L Calheiros M P Manetti-Filho J | | 0，，： | 1 |
| 20 | Deadline-driven provisioning of resources for scientific applications in hybrid clouds with Aneka显示文摘 | VECCIOLA C CALHEIROS R N KARUNAMOORTHY D | 2012 | Euture Generation Computer Sys- tems2012，28，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员