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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Olive oil in parenteral nutrition 显示文摘 | SALA-VILA BARBOSA V M CALDER P C et al | 2007 | Curr Opin Clin Nutr Metab Care2007，10，2： | 1 |
| 3 | Inductive shielding of NMR phase noise显示文摘 | Sigmund E E Mitrovic V F Calder E S | 2002 | J Magn Reson2002，159，2： | 1 |
| 4 | T cells and fibroblastsin affected extraoc ular muscles in early and late thyroidassociated ophthalmopathy显示文摘 | Pappa A Lawson JM Calder V | 2000 | Brjphthalm -ol2000，84，5： | 1 |
| 5 | Mitochondrial permeability transition pore in inflammatory apop- tosis of human conjunctival epithelial cells and T cells: effect of cyclosporin A 显示文摘 | GaoJ Sana R Calder V | 2013 | Invest Ophthal- mol Visl Sci2013，54，7： | 1 |
| 6 | 显示文摘 | Khatko V Calderer J Llobet E | 2005 | Sensors and Actuators B2005，109，： | 1 |
| 7 | Space-time block coding for wireless communications:performance results显示文摘 | TAROKH V JAFARKHANI H CALDER BANK A R | 1999 | IEEE Journal on Selected Areas in Communications1999，17，3： | 1 |
| 8 | Soil enzyme activities, microbial communities, and carbon and nitrogen availability in organic agroecosystems across an intensively-managed agricultural landscape显示文摘 | Bowles T M Acosta-Martínez V Calderón F | 2014 | Soil Biology and Biochemistry2014，68，1： | 1 |
| 9 | So,how deep is the Mariana Trench?显示文摘 | Gardner J V Armstrong A A Calder B R | 2014 | Marine Geodesy2014，37，1： | 1 |
| 10 | Aluminum reactions and problems in municipal solid waste landfills 显示文摘 | Calder G V Stark T D | 2010 | Practice Periodical of Hazardous Toxic and Radioactive Waste Management2010，14，： | 1 |
| 11 | Identi fication and estimation o{ neutral organic contami nants in potable water 显示文摘 | Burnham A K Calder G V Fritz J S | 1972 | Analytical Chemistry1972，44，13： | 1 |
| 12 | Thermoluminescence analysis for testing the irradiation of spices显示文摘 | BBeneitez P Correcher V Millán A Calderón T | 1994 | Journal of Radioanalytical and Nuclear Chemistry1994，185，： | 1 |
| 13 | New data on thermoluminescence of inorganic dust from herbs and spices显示文摘 | Calderón T Correcher V Millán A Beneitez P Rendell H M Larsson M | 1995 | Journal of Physics D-applied Physics1995，28，： | 1 |
| 14 | Adhesion molecule expression in vivo on extraocular muscles (EOM) in thyroid- associated ophthalmopathy (TAO) 显示文摘 | Pappa A Calder V Fells P | 1997 | Clin Exp Immunol1997，108，2： | 1 |
| 15 | Deuterium tracing for the estimation of transpiration from trees: Field ealibration显示文摘 | Calder I R Kariyappa G S Srinivasalu N V | 1992 | Journal of Hydrology1992，130，： | 1 |
| 16 | Adhesion molecule expression in vivo on extraocular muscles in thyroid associated ophthalmopathy 显示文摘 | Pappa A Calder V Fells P Lightman S | 1997 | Clin Exp Immunol1997，108，2： | 1 |
| 17 | Mitochondrial permeability tran- sition pore in inflammatory apoptosis of human conjunctival epi- thelial cells and T cells: effect of cyclosporin A 显示文摘 | Gao J Sana R Calder V | 2013 | Invest Oph- thahnol Vis Sci2013，54，7： | 1 |
| 18 | Tcell and fibroblasts in affected extraocular muscles in early and late thyroid associated ophthalmopathy显示文摘 | Pappa A Lawson JMM Calder v | 2000 | Br J Ophthalmol2000，84，： | 1 |
| 19 | Transmission electron microscopy of Listeria innocua treated by pulsed electric fields and nisin in skimmed milk显示文摘 | Calderó n-Miranda M L Barbosa-Cá novas G V Swanson B G | 1999 | International Journal of Food Microbiology1999，51，： | 1 |
| 20 | Micro-machined WO3-based sensors with improved characteristics显示文摘 | Khatko V Vallejos S Calderer J | 2009 | Sen- sors Actuators B: Chem2009，140，2： | 1 |
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