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| 1 | Intestinal epithelial cells in inflammatory bowel diseases显示文摘The pathogenesis of inflammatory bowel diseases (IBDs) seems to involve a primary defect in one or more of the elements responsible for the maintenance of intestinal homeostasis and oral tolerance. The most important element is represented by the intestinal barrier, a complex system formed mostly by intestinal epithelial cells (IECs). IECs have an active role in producing mucus and regulating its composition; they provide a physical barrier capable of controlling antigen traff ic through the intestinal mucosa. At the same time, they are able to play the role of non-professional antigen presenting cells, by processing and presenting antigens directly to the cells of the intestinal immune system. On the other hand, immune cells regulate epithelial growth and differentiation, producing a continuous bi-directional cross-talk within the barrier. Several alterations of the barrier function have been identif ied in IBD, starting from mucus features up to its components, from epithelial junctions up to the Toll-like receptors, and altered immune responses. It remains to be understood whether these defects are primary causes of epithelial damage or secondary effects. We review the possible role of the epithelial barrier and particularly describe the role of IECs in the pathogenesis of IBD. | Giulia Roda Alessandro Sartini Elisabetta Zambon Andrea Calafiore Margherita Marocchi Alessandra Caponi Andrea Belluzzi Enrico Roda | 2010 | World Journal of Gastroenterology2010，16，34： | 12 |
| 2 | Label-free sensing of ultralow-weight molecules with all-dielectric metasurfaces supporting bound states in the continuum显示文摘The realization of an efficient optical sensor based on a photonic crystal metasurface supporting bound states in the continuum is reported. Liquids with different refractive indices, ranging from 1.4000 to 1.4480, are infiltrated in a microfluidic chamber bonded to the sensing dielectric metasurface. A bulk liquid sensitivity of 178 nm/RIU is achieved, while a Q-factor of about 2000 gives a sensor figure of merit up to 445 in air at both visible and infrared excitations. Furthermore, the detection of ultralow-molecular-weight(186 Da) molecules is demonstrated with a record resonance shift of 6 nm per less than a 1 nm thick single molecular layer. The system exploits a normal-to-the-surface optical launching scheme, with excellent interrogation stability and demonstrates alignment-free performances, overcoming the limits of standard photonic crystals and plasmonic resonant configurations. | SILVIA ROMANO GIANLUIGI ZITO STEFANIA TORINO GIUSEPPE CALAFIORE ERIKA PENZO GIUSEPPE COPPOLA STEFANO CABRINI IVO RENDINA VITO MOCELLA | 2018 | Photonics Research2018，6，7： | 9 |
| 3 | An in vitro prototype of a porcine biomimetic testis-like cell culture system: a novel tool for the study of reassembled Sertoli and Leydig cells显示文摘目前,有在 vitro 不可靠像睾丸的 biomimetic 机关文化系统设计了在 Sertoli 和 Leydig 房间上估计人的 gonadotropins 的功能的效果的装配 prepubertal。精子发生被调整由内分泌, paracrine,和 juxtacrine 因素(阴囊的串音) ,主要由象 luteinizing 荷尔蒙(LH ) 和由分别地刺激 Leydig 和 Sertoli 房间起一个枢轴的作用的刺激滤泡的荷尔蒙(FSH ) 那样的 gonadotropins 安排了。我们的学习的目的是建立一在里面 vitro prepubertal 是的猪的 bioengineered 构造为重新集合的 Sertoli 和 Leydig 房间上的试验性的研究的一个新模型。我们评估了从 15- 获得到 20-day-old 的 Sertoli 和 Leydig 房间新生的猪睾丸以纯净和功能。随后,净化了 Sertoli 并且充实 Leydig 房间受到 coincubation 获得一在里面 vitro prepubertal 猪的像睾丸的文化系统。我们为 anti-M 执行了连接酶的 immunosorbent 试金(ELISA ) | Iva Arato Giovanni Luca Francesca Mancuso Catia Bellucci Cinzia Lilli Mario Calvitti Barbara C Hansen Domenico Milardi Giuseppe Grande Riccardo Calafiore | 2018 | Asian Journal of Andrology2018，20，2： | 4 |
| 4 | Holographic planar lightwave circuit for on-chip spectroscopy显示文摘Computer-generated planar holograms are a powerful approach for designing planar lightwave circuits with unique properties.Digital planar holograms in particular can encode any optical transfer function with high customizability and is compatible with semiconductor lithography techniques and nanoimprint lithography.Here,we demonstrate that the integration of multiple holograms on a single device increases the overall spectral range of the spectrometer and offsets any performance decrement resulting from miniaturization.The validation of a high-resolution spectrometer-on-chip based on digital planar holograms shows performance comparable with that of a macrospectrometer.While maintaining the total device footprint below 2 cm2,the newly developed spectrometer achieved a spectral resolution of 0.15 nm in the red and near infrared range,over a 148 nm spectral range and 926 channels.This approach lays the groundwork for future on-chip spectroscopy and lab-on-chip sensing. | Giuseppe Calafiore Alexander Koshelev Scott Dhuey Alexander Goltsov Pavel Sasorov Sergey Babin Vladimir Yankov Stefano Cabrini Christophe Peroz | 2014 | Light(Science & Applications)2014，3，1： | 3 |
| 5 | Eviendep~ reduces number and size of duodenal polyps in familial adenomatous polyposis patients with ileal pouchanal anastomosis显示文摘AIM:To evaluate if 3 mo oral supplementation with Eviendep was able to reduce the number of duodenal polyps in familial adenomatous polyposis(FAP)patients with ileal pouch-anal anastomosis(IPAA).METHODS:Eleven FAP patients with IPAA and duodenal polyps were enrolled.They underwent upper gastrointestinal(GI)endoscopy at the baseline and after 3 mo of treatment.Each patient received 5 mg Eviendep twice a day,at breakfast and dinner time,for3 mo.Two endoscopists evaluated in a blinded manner the number and size of duodenal polyps.Upper GI endoscopies with biopsies were performed at the baseline(T0)with the assessment of the Spigelman score.Polyps>10 mm were removed during endoscopy and at the end of the procedure a new Spigelman score was determined(T1).The procedure was repeated 3 mo after the baseline(T2).Four photograms were examined for each patient,at T1 and T2.The examined area was divided into 3 segments:duodenal bulb,second and third portion duodenum.Biopsy specimens were taken from all polyps>10 mm and from all suspicious ones,defined by the presence of a central depression,irregular surface,or irregular vascular pattern.Histology was classified according to the updated Vienna criteria.RESULTS:At baseline the mean number of duodenal detected polyps was 27.7 and mean sizes were 15.8mm;the mean Spigelman score was 7.1.After polypectomy the mean number of duodenal detected polyps was 25.7 and mean sizes were 7.6 mm;the mean Spigelman score was 6.4.After 3 mo of Eviendep bid,all patients showed a reduction of number and size of duodenal polyps.The mean number of duodenal polyps was 8(P=0.021)and mean size was 4.4 mm;the mean Spigelman score was 6.6.Interrater agreement was measured.Lesions>1 cm found a very good degree of concordance(kappa 0.851)and a good concordance was as well encountered for smaller lesions(kappa 0.641).CONCLUSION:Our study demonstrated that shortterm(90 d)supplementation with Eviendep in FAP patients with IPAA and with recurrent adenomas in the duodenal mucosa,resulted effective in reducing polyps number of 32%and size of 51%. | Carlo Calabrese Chiara Praticò Andrea Calafiore Maurizio Coscia Lorenzo Gentilini Gilberto Poggioli Paolo Gionchetti Massimo Campieri Fernando Rizzello | 2013 | World Journal of Gastroenterology2013，19，34： | 2 |
| 6 | Optimal matching of three-dimensional features under geometrical constraints显示文摘 | Calafiore G Bona B | 1997 | Proceedings of the IEEE Conference on Decision and Control (S0191-2216)1997，2，7： | 1 |
| 7 | New simple and rapid method for purification of mesenchy- mal stem cells from the human umbilical cord Wharton jelly显示文摘 | Montanucci P G Basta T Pescara I Pennoni F Di Giovanni and R Calafiore | 2011 | Tis- sue Eng Part A2011，，： | 1 |
| 8 | Mitral valve surgery for functional mitral regurgitation: should moderate-or-more tricuspid regurgitation be treated? a propensity score analysis显示文摘 | Calafiore AM Gallina S Iacb AL | 2009 | Ann Tho- rac Surg2009，87，3： | 1 |
| 9 | Intermittent antegrade hyperkalaemic warm blood cardioplegia supplemented with magnesium prevents myocardial substrate derangement in patients undergoing coronary artery bypass surgery显示文摘 | Caputo M Bryan AJ Calafiore AM | 1998 | Eur J Cardiothoracic Surg1998，14，： | 1 |
| 10 | Robust filtering for discrete-time systems with bounded noise and parametric uncertainty显示文摘 | Ghaoui L Calafiore G | 2001 | IEEE Transactions on Automatic Control2001，46，7： | 1 |
| 11 | Alginate-based microcapsules for immunoisolation of pancreatic islets 显示文摘 | de Vos P Faas M M Strand B Calafiore R | 2006 | Biomaterials2006，27，32： | 1 |
| 12 | TGF-beta1 targets the GSK-3beta/ beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts显示文摘 | CARACI F GILI E CALAFIORE M | 2008 | Pharmacol Res2008，57，4： | 1 |
| 13 | Distributionally robust chance-constrained linear programms with applications显示文摘 | Calafiore G Ghaoui L | | 0，，1： | 1 |
| 14 | Uncertain convex programming:randomized solutions and confidence levels显示文摘 | Calafiore G Campi M C | | 0，，1： | 1 |
| 15 | The scenario approach to robust control design显示文摘 | Calafiore G Canpi M C | | 0，，5： | 1 |
| 16 | Bilateral internal mammary artery grafting 显示文摘 | CALAFIORE A M DI MAURO M | 2006 | Expert Rev Cardiovasc Ther2006，4，3： | 1 |
| 17 | Multi-period portfolio optimization with linear control policies显示文摘 | Calafiore G C | 2008 | Automatica2008，44，10： | 1 |
| 18 | Robot dynamic calibration:optimal excitation trajectories and experimental parameter estimation显示文摘 | CALAFIORE G INDRI M BONA B | 2001 | Journal of Robotic System2001，18，2： | 1 |
| 19 | Group l metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice显示文摘 | Castiglione M Calafiore M Costa L | 2008 | Neuropharmacology2008，55，4： | 1 |
| 20 | Transplantation of minimal volume microcapsules in diabetic high mammalians显示文摘 | Calafiore R Basta G Luca G | 1999 | Ann New YorkAcad Sci1999，875，： | 1 |
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