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| 1 | Current and future treatments for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) represents a unique challenge for physicians and patients.There is no definitively curative treatment.Rather,many treatment and management modalities exist with differing advantages and disadvantages.Both current guidelines and individual patient concerns must be taken into account in order to properly manage HCC.In addition,quality of life issues are particularly complex in patients with HCC and these concerns must also be factored into treatment strategies.Thus,considering all the options and their various pros and cons can quickly become complex for both clinicians and patients.In this review,we systematically discuss the current treatment modalities available for HCC,detailing relevant clinical data,risks and rewards and overall outcomes for each approach.Surgical options discussed include resection,transplantation and ablation.We also discuss the radiation modalities:conformal radiotherapy,yttrium 90 microspheres and proton and heavy ion radiotherapy.The biologic agent Sorafenib is discussed as a promising new approach,and recent clinical trials are reviewed.We then detail currently described molecular pathways implicated in the initiation and progression of HCC,and we explore the potential of each pathway as an avenue for drug exploitation.We hope this comprehensive and forward-looking review enables both clinicians and patients to understand various options and thereby make more informed decisions regarding this disease. | Alexander Schlachterman Willie W Craft Jr Eric Hilgenfeldt Avir Mitra Roniel Cabrera | 2015 | World Journal of Gastroenterology2015，21，28： | 76 |
| 2 | Determinants of individual engagement in knowledge sharing显示文摘 | Cabrera A Collins W C Salgado J F | 2006 | International Journal of HumanResource Management2006，17，2： | 1 |
| 3 | Extrapolation and spectral estimation with iterative weighted norm modification显示文摘 | Cabrera S D Parks T W | 1991 | IEEE Transactions on Signal Processing1991，9，4： | 1 |
| 4 | Characterization and resolution of evaporation-mediated osmolality shifts that constrain microfluidic cell culture in poly (dimethylsiloxane) devices 显示文摘 | HEO Y S CABRERA L M SONG J W | 2007 | Anal Chem2007，79，3： | 1 |
| 5 | Determinants of individual engagement in knowledge sharing 显示文摘 | Cabrera A Collins W C Salgado J F | 2006 | The International Journal of Human Resource Management2006，，2： | 1 |
| 6 | Determinants of individual engagement in knowledge sharing 显示文摘 | Cabrera A Collins W C Salgado J F | 2006 | International Journal of Human Resource Management2006，17，： | 1 |
| 7 | The growth of crystals and the equilibrium structure of their surfaces显示文摘 | Burton W K Cabrera N Frank F C | 1950 | Phil Tran Royal Soc1950，243，： | 1 |
| 8 | Rapid verification of wheat-Hordeum introgressions by direct staining of SCAR,STS,and SSR amplicons显示文摘 | HERNANDEZ P DORADO G CABRERA A LAURIE D A SNAPE J W MARTIN A | 2002 | Genome2002，45，： | 1 |
| 9 | Determinants o individual engagement in knowledge sharing 显示文摘 | CABRERA A COLLINS W SALGADO J | 2006 | Interna- tional Journal of Human Resource Management2006，17，2： | 1 |
| 10 | Struc- tural,transport,magnetic,and thermal properties of Eu8 Ga16 Ge3o 显示文摘 | Paschen S Cabrera W C Bentien A | 2001 | Phys Rev B2001，64，21： | 1 |
| 11 | Laparoscopic pyeloplasty: technique and results in 80 consecutive patients 显示文摘 | Castillo OA Cabrera W Aleman E | 2014 | Actas Urol Esp2014，38，2： | 1 |
| 12 | Determinants of individual engagement in knowledge sharing显示文摘 | Cabrera A Collins W C Salgado J F | 2006 | In- ternational Journal of Human Resource Management2006，17，2： | 1 |
| 13 | Vps41 phosphorylation and the Rab Ypt7 control the targeting of the HOPS complex to endosome-vacuole fusion sites显示文摘 | CABRERA M OSTROWICZ C W MARI M | 2009 | Molecular Biology of the Cell2009，20，7： | 1 |
| 14 | Determinants of Individual Engagement in Knowl显示文摘 | CABRERA A COLLINS W C SELGADO J F | 2006 | International Journal of Human Resource Management2006，17，2： | 1 |
| 15 | Determinants of individual engagement in knowledge sharing显示文摘 | Cabrera A Collins W C Salgado J F | 2006 | In- ternational Journal of Human Resource Management2006，17，2： | 1 |
| 16 | Determinants of individual engage- ment in knowledge sharing 显示文摘 | CABRERA A COLLINS W C | 2006 | International Journal of Human Re- source Management2006，17，2： | 1 |
| 17 | Age of thelarche and menarche in contemporary US females: a cross-sectional analysis 显示文摘 | CABRERA S M BRIGHT G M FRANE J W | 2014 | J Pediatr Endocrinol Metah2014，27，12： | 1 |
| 18 | Yacon syrup: Beneficial effects on obesity and insulin resistance in humans显示文摘 | GENTA S CABRERA W HABIB N | 2009 | Clinical Nutrition2009，28，2： | 1 |
| 19 | Priapism in a patient with chronic myeloid leukemia显示文摘 | Rojas B Cabrera ME Kliwadenko W | 1998 | Rev Med Chil1998，126，8： | 1 |
| 20 | Determinants of Individ- ual Engagement in Knowledge Sharing 显示文摘 | Cabrera A Collins W C Salgado J F | 2006 | The International Journal of Human Resource Management2006，17，2： | 1 |
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