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| 1 | Surveys in Areas of High Risk of Iodine Deficiency and Iodine Excess in China, 2012-2014: Current Status and Examination of the Relationship between Urinary Iodine Concentration and Goiter Prevalence in Children Aged 8-10 Years显示文摘Objective We aimed to evaluate goiter prevalence and iodine nutritional status in areas with high levels of water iodine;to monitor the prevalence of iodine deficiency disorders(IDD)in areas at high risk of IDD;and to compare the prevalence of goiter and urine iodine(UI)concentrations between children living in the two areas.Methods Based on surveillance from 2012-2014,we analyzed the concentration of UI and prevalence of goiter in 8-10-year-old children from 12 high-risk IDD provinces,and from 8 provinces and municipalities with excessive water iodine.We calculated goiter prevalence for each UI level according to World Health Organization(WHO)standards and constructed predictive prevalence curves.Results The goiter prevalence and median UI of children from areas with high water iodine were not optimal,being above the WHO standards(5%and 100-199μg/L,respectively),whereas those in high-risk areas fell within the standard.UI and goiter prevalence exhibited a U-shaped relationship in high-risk endemic areas and a parabolic relationship in areas of iodine excess.Conclusion Iodine surplus in high-iodine areas leads to high goiter prevalence and UI.However,in high-risk areas,UI was optimal and goiter prevalence met the national criteria for IDD elimination. | CUI Si Lu LIU Peng SU Xiao Hui LIU Shou Jun | 2017 | Biomedical and Environmental Sciences2017，30，2： | 6 |
| 2 | A Phase Ⅱ Study of Fotemustine Plus Dacarbazine with Dendritic Cell Vaccines as First-Line Therapy for Chinese Patients with Advanced Acral Lentiginous Melanoma显示文摘Objective:To investigate fotemustine plus dacarbazine(DTIC) with dendritic cell(DC) vaccines on patients with advanced acral lentiginous melanoma(ALM). Fotemustine is a cytotoxic alkylating agent with a remarkable antitumor activity as single agent but also in association with(DTIC). DC is the strongest antigen presenting cell which could induce durable clinical responses. Methods:This was a single-center study. Between July 2003 and June 2006,twenty-eight chemotherapy-naive patients of advanced ALM received fotemustine 100 mg/m2,d1,12,DTIC 400 mg/d d2-6,DC vaccines subcutaneously d7,9,13 repeated every 28 days. Ten HLA-A02+24+ patients received vaccines pulsed with melanoma antigen derived peptides,melanoma antigen recognized by T-cells 1(Mart-1) and S-100. Eighteen patients received DC loaded with allogeneic melanoma lysate. The primary end-point was progression free survival(PFS). Secondary end-points were overall survival(OS),overall response rate(ORR) and toxicity. Tumor assessment was performed every 8 weeks and evaluated according to response evaluation criteria in solid tumors(RECIST). Results:The 15 men and 13 women had a median age of 51 years. 16 patients had stage M1c disease and 11/16 had liver metastasis. Patients received an average of 3.82±1.25 cycles. Follow-up for the 18 surviving patients ranged from 7-41 months with a median of 12 months. Median PFS was 8.5 months(95% CI:7.86-15.21) with 12 patients remaining progression free. Only 10 patients died. Median OS was 12 months(95% CI:10.33-18.24). ORR(CR+PR) was 35.7% including 3 complete response(CR) and 7 partial response(PR). Six patients had disease stable. A total of 19 Grade III/IV toxicities were observed including thrombocytopenia(n=8),neutropenia(n=5),fatigue(n=6) and hypersensitivity reaction(n=1). One patient died of Grade IV thrombocytopenia. Conclusion:Fotemustine and dacarbazine plus DC vaccines are safe and tolerable to Chinese ALM patients. The regimen brings clinical benefit with a higher ORR and may provide a survival advantage. Updated survival data will be presented. | Lu Si Zhi-hong Chi Xiang-qing Yuan Chuan-liang Cui Xi-nan Sheng Jun Guo | 2009 | Chinese Journal of Cancer Research2009，21，1： | 1 |
| 3 | Detection of Syndecan-1 and Heparanase-1 Genes in Esophageal Carcinoma by Quantitative RT-PCR显示文摘 | Jun-li SI Yu-qin QI Jing-yuan CUI Song-mei WANG He WANG Mei LU | 2010 | Clinical oncology and cancer resexreh2010，7，4： | 1 |
| 4 | The DIRECT consortium and the REST-meta-MDD project:towards neuroimaging biomarkers of major depressive disorder显示文摘Despite a growing neuroimaging literature on the pathophysiology of major depressive disorder(MDD),repro-ducible findings are lacking,probably reflecting mostly small sample sizes and heterogeneity in analytic approaches.To address these issues,the Depression Imaging REsearch ConsorTium(DIRECT)was launched.The REST-meta-MDD project,pooling 2428 functional brain images processed with a standardized pipeline across all participating sites,has been the first effort from DIRECT.In this review,we present an overview of the moti-vations,rationale,and principal findings of the studies so far from the REST-meta-MDD project.Findings from the first round of analyses of the pooled repository have included alterations in functional connectivity within the default mode network,in whole-brain topological properties,in dynamic features,and in functional lat-eralization.These well-powered exploratory observations have also provided the basis for future longitudinal hypothesis-driven research.Following these fruitful explorations,DIRECT has proceeded to its second stage of data sharing that seeks to examine ethnicity in brain alterations in MDD by extending the exclusive Chinese original sample to other ethnic groups through international collaborations.A state-of-the-art,surface-based preprocessing pipeline has also been introduced to improve sensitivity.Functional images from patients with bipolar disorder and schizophrenia will be included to identify shared and unique abnormalities across diag-nosis boundaries.In addition,large-scale longitudinal studies targeting brain network alterations following antidepressant treatment,aggregation of diffusion tensor images,and the development of functional magnetic resonance imaging-guided neuromodulation approaches are underway.Through these endeavours,we hope to accelerate the translation of functional neuroimaging findings to clinical use,such as evaluating longitudinal effects of antidepressant medications and developing individualized neuromodulation targets,while building an open repository for the scientific community. | Xiao Chen Bin Lu Hui-Xian Li Xue-Ying Li Yu-Wei Wang Francisco Xavier Castellanos Li-Ping Cao Ning-Xuan Chen Wei Chen Yu-Qi Cheng Shi-Xian Cui Zhao-Yu Deng Yi-Ru Fang Qi-Yong Gong Wen-Bin Guo Zheng-Jia-Yi Hu Li Kuang Bao-Juan Li Le Li Tao Li Tao Lian Yi-Fan Liao Yan-Song Liu Zhe-Ning Liu Jian-Ping Lu Qing-Hua Luo Hua-Qing Meng Dai-Hui Peng Jiang Qiu Yue-Di Shen Tian-Mei Si Yan-Qing Tang Chuan-Yue Wang Fei Wang Hua-Ning Wang Kai Wang Xiang Wang Ying Wang Zi-Han Wang Xiao-Ping Wu Chun-Ming Xie Guang-Rong Xie Peng Xie Xiu-Feng Xu Hong Yang Jian Yang Shu-Qiao Yao Yong-Qiang Yu Yong-Gui Yuan Ke-Rang Zhang Wei Zhang Zhi-Jun Zhang Jun-Juan Zhu Xi-Nian Zuo Jing-Ping Zhao Yu-Feng Zang the DIRECT consortium Chao-Gan Yan | 2022 | Psychoradiology2022，2，1： | 1 |
| 5 | Constraining self-interacting dark matter with the full dataset of PandaX-II显示文摘Self-interacting dark matter(SIDM)is a leading candidate proposed to solve discrepancies between predictions of the prevailing cold dark matter theory and observations of galaxies.Many SIDM models predict the existence of a light force carrier that mediates strong dark matter self-interactions.If the mediator couples to the standard model particles,it could produce characteristic signals in dark matter direct detection experiments.We report searches for signals of SIDM models with a light mediator using the full dataset of the PandaX-II experiment,basing on a total exposure of 132 tonne-days.No significant excess over background is found,and our likelihood analysis leads to a strong upper limit on the dark matter-nucleon coupling strength.We further combine the PandaX-II constraints and those from observations of the light element abundances in the early universe,and show that direct detection and cosmological probes can provide complementary constraints on dark matter models with a light mediator. | Jijun Yang Abdusalam Abdukerim Wei Chen Xun Chen Yunhua Chen Chen Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Shengming He Di Huang Yan Huang Ran Huo Yanlin Huang Zhou Huang Xiangdong Ji Yonglin Ju Shuaijie Li Qing Lin Huaxuan Liu Jianglai Liu Xiaoying Lu Wenbo Ma Yugang Ma Yajun Mao Yue Meng Nasir Shaheed Kaixiang Ni Jinhua Ning Xuyang Ning Xiangxiang Ren Changsong Shang Guofang Shen Lin Si Andi Tan Anqing Wang Hongwei Wang Meng Wang QiuHong Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Shiyong Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Yong Yang Chunxu Yu Hai-Bo Yu Jumin Yuan Ying Yuan Xinning Zeng Dan Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，11： | 0 |
| 6 | A summary of the evidence and evaluation of the effectiveness of nonpharmacological interventions for mild cognitive impairment显示文摘Objective: To summarize and evaluate the evidence of guidelines and systematic reviews(SRs) of nonpharmacological interventions for mild cognitive impairment(MCI) to support the development of future guidelines and clinical decisions for MCI patients.Methods: Scottish Intercollegiate Guideline Network(SIGN), National Institute for Health and Clinical Excellence(NICE), American Academy of Neurology(AAN), Registered Nurses Association of Ontario(RNAO), Web of Science, PubMed, Cochrane Library, CNAHL, VIP, China National Knowledge Infrastructure(CNKI), and Wanfang Database were searched for relevant publications, including guidelines and SRs, from January 2014 to March 2019. Two authors independently screened articles, extracted data, and assessed the publications for adherence to the inclusion criteria. Appraisal of Guidelines for Research and Evaluation(AGREE II) was used to assess the quality of the guidelines, and Assessment of Multiple Systematic Reviews(AMSTAR 2) was used to assess the quality of SRs. In addition, the Grading of Recommendations Assessment, Development and Evaluation(GRADE) approach was used to evaluate the quality of outcomes.Results: Thirty-two articles were retrieved, including 1 guideline and 31 SRs. Fourteen SRs of physical exercise for MCI, six articles describing cognitive interventions, four articles describing acupuncture, and seven articles assessing dietary interventions(including four articles employing a Mediterranean diet, one article using vitamin B supplementation, and two articles assessing the effects of tea, coffee, and caffeine) were included. The quality of the articles was very low for 4(13%), low for 10(32%), and moderate for 17(55%).Conclusions: Based on the evidence available to date, nonpharmacological interventions may improve the current cognitive function of persons with MCI. In particular, physical exercise, cognitive interventions, and acupuncture exerted promising effects. However, due to the limited number and quality of the included publications, additional high-quality reviews are needed to further confirm. | Zi-Meng Li Ying-Hui Jin Yun-Yun Wang Lu Cui Wei-Jie Gao Jin-Hua Si Yan-Hui Liu | 2019 | Frontiers of Nursing2019，6，4： | 0 |
| 7 | Determination of Double Beta Decay Half-Life of 136Xe with the PandaX-4T Natural Xenon Detector显示文摘Precise measurement of two-neutrino double beta decay(DBD)half-life is an important step for the searches of Majorana neutrinos with neutrinoless double beta decay.We report the measurement of DBD half-life of 136xe using the Pandax-4T dual-phase Time Projection Chamber(TPC)with 3.7-tonne natural xenon and the first 94.9-day physics data release. | Lin Si Zhaokan Cheng Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Yunhua Chen Chen Cheng Yunshan Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Jinrong He Di Huang Yanlin Huang Zhou Huang Ruquan Hou Xiangdong Ji Yonglin Ju Chenxiang Li Jiafu Li Mingchuan Li Shu Li Shuaijie Li Qing Lin Jianglai Liu Xiaoying Lu Lingyin Luo Yunyang Luo Wenbo Ma Yugang Ma Yujun Mao Yue Meng Nasir Shaheed Xiaofeng Shang Xuyang Ning Ningchun Qi Zhicheng Qian Xiangxiang Ren Changsong Shang Guofang Shen Wenliang Sun Andi Tan Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Yuehuan Wei Mengmeng Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Xiyu Yan Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Zhe Yuan Dan Zhang Minzhen Zhang Peng Zhang Shibo Zhang Shu Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou Yong Zhou | 2023 | Research2023，，2： | 0 |
| 8 | Bibliometric analysis of subject trends and knowledge structures of gut microbiota显示文摘BACKGROUND Gut microbiota is an emerging field of research,with related research having breakthrough development in the past 15 years.Bibliometric analysis can be applied to analyze the evolutionary trends and emerging hotspots in this field.AIM To study the subject trends and knowledge structures of gut microbiota related research fields from 2004 to 2018.METHODS The literature data on gut microbiota were identified and downloaded from the PubMed database.Through biclustering analysis,strategic diagrams,and social network analysis diagrams,the main trend and knowledge structure of research fields concerning gut microbiota were analyzed to obtain and compare the research hotspots in each period.RESULTS According to the strategic coordinates and social relationship network map,Clostridium Infections/microbiology,Clostridium Infections/therapy,RNA,Ribosomal,16S/genetics,Microbiota/genetics,Microbiota/immunology,Dysbiosis/immunology,Infla-mmation/immunology,Fecal Microbiota Transplantation/methods,Fecal Microbiota Transplantation can be used as an emerging research hotspot in the past 5 years(2014-2018).CONCLUSION Some subjects were not yet fully studied according to the strategic coordinates;and the emerging hotspots in the social network map can be considered as directions of future research. | Yuan-Yi Yue Xin-Yue Fan Qiang Zhang Yi-Ping Lu Si Wu Shuang Wang Miao Yu Chang-Wan Cui Zheng-Rong Sun | 2020 | World Journal of Clinical Cases2020，8，13： | 0 |
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