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| 1 | Plasma betatrophin levels in patients with liver cirrhosis显示文摘AIM: To investigate the plasma levels of betatrophin in patients with cirrhosis.METHODS: Forty patients diagnosed at the clinic with liver cirrhosis according to biological, ultrasonographic,or histological criteria were included.The severity of cirrhosis was classified according to Pugh's modification of Child's classification and MELD score. Insulin resistance(IR) was assessed by the Homeostasis Model Assessment. A total of 20 patients showed a MELD score higher than 14. The control group consisted in 15 sex-and aged-matched subjects.Fasting blood samples were obtained for subsequent analysis. Serum insulin was determined by Liaison automated immune chemiluminiscence assay(DiaSorin S.p.A.) using a sandwich assay. The sensitivity of the assay was 0.2 μU/mL. The intra and interassay variation coefficients were < 4% and < 10%,respectively. The normal values were between 2 and17 μU/mL. Human active betatrophin was analyzed by specific quantitative sandwich ELISA(Aviscera Bioscience). The sensitivity of the assay was 0.4 ng/mL, and the intra and interassay reproducibility were< 6% and < 10%, respectively.RESULTS: Plasma betatrophin levels were significantly increased in patients with cirrhosis compared with those in healthy subjects(P = 0.0001). Betatrophin levels were also associated with disease severity, being higher in Child-Pugh C patients compared to Child-Pugh B(P< 0.0005) and in patients who displayed a MELD score higher than 14 points compared to patients with lower punctuation(P = 0.01). In addition, we found a positive correlation between plasma betatrophin levels and the severity of cirrhosis according to Child-Pugh classification(r = 0.53; P < 0.01) or MELD score(r = 0.45; P <0.01). In the overall cohort, a moderate correlation between serum betatrophin and plasmatic bilirrubin(r= 0.39; P < 0.01) has been observed, as well as an inverse correlation between betatrophin and albumin(r =-0.41; P < 0.01) or prothrombin time(r =-0.44;P <0.01). Moreover, insulin resistance was observed in82.5% of the cirrhotic patients. In this group of patients,betatrophin levels were significantly higher than those in the group of patients without IR(P < 0.05).CONCLUSION: Plasma betatrophin is increased in patients with cirrhosis. This increase is related to the severity of cirrhosis, as well as with the emergence of insulin resistance. | Maria Teresa Arias-Loste Maria Teresa García-Unzueta Susana Llerena Paula Iruzubieta Angela Puente Joaquín Cabezas Carmen Alonso Antonio Cuadrado José Antonio Amado Javier Crespo Emilio Fábrega | 2015 | World Journal of Gastroenterology2015，21，37： | 9 |
| 2 | Impact of an acute hemodynamic response-guided protocol for primary prophylaxis of variceal bleeding显示文摘AIM To evaluate the long-term outcome of an acute hemodynamic response-guided protocol in which acute responders to intravenous propranolol received traditional nonselective beta-blockers(NSBBs) and acute nonresponders received carvedilol.METHODS Retrospective review of a protocol for primary prophylaxis of variceal bleeding guided by the acute hemodynamic response to intravenous propranolol. Fifty-two acute responders treated with traditional NSBB(i.e. propranolol or nadolol) were compared with 24 acute nonresponders receiving carvedilol. A second hemodynamic study was performed in 27 and 13 patients, respectively. The primary endpoint was development of first or further decompensation. Secondary endpoints included death from any cause, association between acute and chronic hemodynamic response, and baseline clinical and laboratory variables related to the acute hemodynamic response.RESULTS Acute responders and acute nonresponders presented similar 1, 2, and 3-year probabilities of first decompensation(NSBB: 0%, 13.7%, 26.1% vs carvedilol: 0%, 20%, 20%, P = 0.968) or further decompensation(21.2%, 26.1%, 40.9% vs 21.2%, 50.0%, 50.0%, P = 0.525). A previous episode of hepatic encephalopathy was the only independent predictor of decompensation [hazard ratio(95% confidence interval): 8.03(2.76-23.37)]. Mortality rates were similar in acute responders and acute nonresponders with compensated(P = 0.428) or decompensated cirrhosis(P = 0.429). No clinical, laboratory, endoscopic or hemodynamic parameter predicted the acute hemodynamic response. In patients receiving traditional NSBB, the acute and chronic changes of hepatic venous pressure gradient were correlated(r = 0.59, P = 0.001). Up to 69.2% of acute nonresponders gained chronic response with carvedilol.CONCLUSION Early identification and treatment with carvedilol of acute nonresponders to intravenous propranolol improves the clinical outcome of this high-risk group of patients, probably due to its greater effects for reducing portal pressure. | José Ignacio Fortea ángela Puente Patricia Ruiz Iranzu Ezcurra Javier Vaquero Antonio Cuadrado María Teresa Arias-Loste Joaquín Cabezas Susana Llerena Paula Iruzubieta Carlos Rodríguez-Lope Patricia Huelin Fernando Casafont Emilio Fábrega Javier Crespo | 2018 | World Journal of Clinical Cases2018，6，13： | 6 |
| 3 | Clinical significance of donor-specific human leukocyte antigen antibodies in liver transplantation显示文摘Antibody-mediated rejection(AMR) caused by donorspecific anti-human leukocyte antigen antibodies(DSA) is widely accepted to be a risk factor for decreased graft survival after kidney transplantation. This entity also plays a pathogenic role in other solid organ transplants as it appears to be an increasingly common cause of heart graft dysfunction and an emerging issue in lung transplantation. In contrast, the liver appears relatively resistant to DSA-mediated injury. This 'immune-tolerance' liver property has been sustained by a low rate of liver graft loss in patients with preformed DSA and by the intrinsic liver characteristics that favor the absorption and elimination of DSA; however, alloantibody-mediated adverse consequences are increasingly being recognized, and several cases of acute AMR after ABO-compatible liver transplant(LT) have been reported. Furthermore, the availability of new solid-phase assays, allowing the detection of low titers of DSA and the refinement of objective diagnostic criteria for AMR in solid organ transplants and particularly in LT, have improved the recognition and management of this entity. A cost-effective strategy of DSA monitoring, avoidance of class Ⅱ human leukocyte antigen mismatching, judicious immunosuppression attached to a higher level of clinical suspicion of AMR, particularly in cases unresponsive to conventional antirejection therapy, can allow a rational approach to this threat. | Antonio Cuadrado David San Segundo Marcos López-Hoyos Javier Crespo Emilio Fábrega | 2015 | World Journal of Gastroenterology2015，21，39： | 5 |
| 4 | 笔记, MANOS, SILS 和另外的新 laparoendoscopic 技术显示文摘 A new way of opening a body cavity can be a revolution in surgery.In 1980s,laparoscopy changed how surgeons had been working for years.Natural orifice translumenal endoscopic surgery(NOTES),minilaparoscopy-assisted natural orifice surgery(MANOS),single incision laparoscopic surgery(SILS) and other new techniques are the new paradigm in our way of operating in the 21 st century.The development of these techniques began in the late 90s but they have not had enough impact to develop and evolve.Parallels between the first years of laparoscopy and NOTES can be made.Working for an invisible surgery,not only for cosmesis but for a less invasive surgery,is the target of NOTES,MANOS and SILS performed by surgeons and endoscopists over the last 10 years.The future flexible endoscopic platforms and the fusion between laparoscopic instruments and devices and robotic surgery will be a great advance for 'scarless surgery'. | José F Noguera Angel Cuadrado | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，6： | 2 |
| 5 | Computerized physician order entry‐based system to prevent HBV reactivation in patients treated with biologic agents: The PRESCRIB project显示文摘 | Blanca Sampedro Cándido Hernández‐López José Ramón Ferrandiz Aitziber Illaro Emilio Fábrega Antonio Cuadrado Paula Iruzubieta Susana Menéndez Joaquín Cabezas Javier Crespo | 2014 | Hepatology2014，，1： | 2 |
| 6 | VAC(vacuum-as- sisted closure)'covered'laparostomy to control abdominal compartmental syndrome in a case of emphysematous pancreatitis显示文摘 | Camps I Armtar F Cuadrado M | 2009 | Cir Esa2009，86，4： | 1 |
| 7 | Enzymatic hydrolysis of vegetable proteins:mechanism and kinetics显示文摘 | Mereno M C M Cuadrado V F | 1993 | Process Biochem1993，28，： | 1 |
| 8 | 显示文摘 | Gonzalez M F Ruseckaite R A Cuadrado T R | 1999 | Journal of Applied Polymer Science1999，71，8： | 1 |
| 9 | Reversible coma caused by risperidone-ritonavir interaction显示文摘 | Jover F Cuadrado JM Andreu L Merino J | 2002 | Clin Neuropharmacol2002，25，： | 1 |
| 10 | The management of thrombosis in the antiphospholipid-antibody syndrome显示文摘 | Khamashta MA Cuadrado MJ Mujic F | 1995 | N Ehgl J Med1995，，： | 1 |
| 11 | Labdane diterpenes protect against anoxia/reperfusion injury in cardiomyocytes:involvement of AKT activation 显示文摘 | CUADRADO I VELASCO F M BOSCA L | 2011 | Cell Death and Disease2011，2，： | 1 |
| 12 | AplidinTM induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor,Src,JNK,and p38 MAPK显示文摘 | Cuadrado A Garcia-Fernandez L F Munoz A | 2003 | J Biol Chem2003，278，1： | 1 |
| 13 | Levofloxacin versus clarithromycin in a 10 day triple ther- apy regimen for first - line Helicobaeter pylori eradication: a single- blind randomized? clinical trial 显示文摘 | Cuadrado - Lavin A Saleines - Caviedes J R Carrasco M F | 2012 | J Antimicrob Chemother2012，67，9： | 1 |
| 14 | Immunosuppressive therapy in lupus nephritis显示文摘 | D Cruz D Cuadrado MJ Mujic F et a1 | 1997 | Clin Exp Rheumatol1997，15，3： | 1 |
| 15 | The managemgnt of thrombosis in the antiphospholipid- antibody syndrome显示文摘 | Cuadrado MJ Mujic F | 1995 | N Engl Med1995，332，： | 1 |
| 16 | Reversible coma caused by risper -idoneritonavir interaction显示文摘 | Jover F Cuadrado JM Andreu L | 2002 | Clin Neuropharmacol2002，25，5： | 1 |
| 17 | A formulation for path plan- ning of manipulators in complex environments by using adja- cent configurations显示文摘 | Valero F Mata V Cuadrado J I | 1997 | Advanced Robotics1997，11，1： | 1 |
| 18 | xDGP: a dynamic graph processing system with adaptive partitioning显示文摘 | VAQUERO L CUADRADO F LOGOTHETIS D | 2013 | Eprint Arxiv2013，，9： | 1 |
| 19 | Hydric properties of some Spanish soils in relation to their rock fragment content: implications for runoff and vegetation 显示文摘 | Ingelmo F Cuadrado S Ibanez A | 1994 | Catena1994，23，： | 1 |
| 20 | Incidental in vivo detection of an isolated hemangioma of the aortic valve in a man with a history of renal transplantation显示文摘 | VAL-BERNAL J F CUADRADO M GARIJO M F | 2006 | Virchows Arch2006，449，： | 1 |
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