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| 1 | Integrated lipidomics and proteomics network analysis highlights lipid and immunity pathways associated with Alzheimer's disease显示文摘Background:There is an urgent need to understand the pathways and processes underlying Alzheimer's disease(AD)for early diagnosis and development of effective treatments.This study was aimed to investigate Alzheimer's dementia using an unsupervised lipid,protein and gene multi-omics integrative approach.Methods:A lipidomics dataset comprising 185 AD patients,40 mild cognitive impairment(MCI)individuals and 185 controls,and two proteomics datasets(295 AD,159 MCI and 197 controls)were used for weighted gene CO-expression network analyses(WGCNA).Correlations of modules created within each modality with clinical AD diagnosis,brain atrophy measures and disease progression,as well as their correlations with each other,were analyzed.Gene ontology enrichment analysis was employed to examine the biological processes and molecular and cellular functions of protein modules associated with AD phenotypes.Lipid species were annotated in the lipid modules associated with AD phenotypes.The associations between established AD risk loci and the lipid/protein modules that showed high correlation with AD phenotypes were also explored.Results:Five of the 20 identified lipid modules and five of the 17 identified protein modules were correlated with clinical AD diagnosis,brain atrophy measures and disease progression.The lipid modules comprising phospholipids,triglycerides,sphingolipids and cholesterol esters were correlated with AD risk loci involved in immune response and lipid metabolism.The five protein modules involved in positive regulation of cytokine production,neutrophil-mediated immunity,and humoral immune responses were correlated with AD risk loci involved in immune and complement systems and in lipid metabolism(the APOE ε4 genotype).Conclusions:Modules of tightly regulated lipids and proteins,drivers in lipid homeostasis and innate immunity,are strongly associated with AD phenotypes. | Jin Xu Giulia Bankov Min Kim Asger Wretlind Jodie Lord Rebecca Green Angela Hodges Abdul Hye Dag Aarsland Latha Velayudhan Richard J.B.Dobson Petroula Proitsi Cristina Legido-Quigley on behalf of the AddNeuroMed Consortium | 2020 | Translational Neurodegeneration2020，9，3： | 3 |
| 2 | Genome-wide inhibitory impact of the AMPK activator metformin on M-phase cell cycle genes in human breast cancer cells 显示文摘 | CRISTINA OF ALEJANDRO VM MENENDEZ JA | 2009 | Cell Cycle2009，8，10： | 1 |
| 3 | cal Alloying and Its Consolidition显示文摘 | Munoz-Palos J M Cristina M C Aedva E Synthesis of Mg2Si Powder by Mechani | 1996 | Mater Trans1996，37，10： | 1 |
| 4 | Colorectal cancer prognosis twenty years later显示文摘AIM:To evaluate changes in colorectal cancer(CRC) survival over the last 20 years.METHODS:We compared two groups of consecutive CRC patients that were prospectively recruited:Group Ⅰincluded 1990 patients diagnosed between 1980 and 1994.GroupⅡincluded 871 patients diagnosed in 2001.RESULTS:The average follow up time was 21 mo(1-229)for GroupⅠand 50 mo(1-73.4)for GroupⅡ.Overall median survival was significantly longer in Group Ⅱthan in GroupⅠ(73 mo vs 25 mo,P<0.001)and the difference was significant for all tumor stages.Post surgical mortality was 8% for GroupⅠand 2% for Group Ⅱ(P<0.001).Only 17% of GroupⅠpatients received chemotherapy compared with 50% of GroupⅡpatients(P<0.001).CONCLUSION:Survival in colorectal cancer patients has doubled over the past 20 years.This increase seems to be partly due to the generalization in the administration of chemotherapy and to the decrease of post surgical mortality. | Luis Bujanda Cristina Sarasqueta Elisabeth Hijona Lander Hijona Angel Cosme Ines Gil Jose Luis Elorza Jose I Asensio Santiago Larburu José M Enríquez-Navascués Rodrigo Jover Francesc Balaguer Xavier Llor Xavier Bessa Montserrat Andreu Artemio Paya Antoni Castells Gastrointestinal Oncology Group of the Spanish Gastroenterological Association | 2010 | World Journal of Gastroenterology2010，16，7： | 0 |
| 5 | 温雅静敛闲处之 坐看平湖生烟雨显示文摘想象着,安静的湖面上下起绵绵细雨,烟雾朦胧袅袅升起,远处的青山、近处的烟雨、优雅静怡的天青色,如此诗意、静好的场景!有段时间,我们可能都曾被这样的一句话刷屏:生活不止眼前的苟且,还有诗和远方。在如此纷繁复杂的世界里,有多少人能够不当一只“蜗牛”?但即便如此,我们还是不能失去对诗意生活的向往。 | Republic of Fritz Hansen Cristina Celestino Paolo Polloniato 李薇 | 2017 | 现代装饰2017，0，5： | 0 |
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