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| 1 | Personalized medicine in gastric cancer:Where are we andwhere are we going?显示文摘Despite improvements in adjuvant therapies for gastric cancer in recent years, the disease is characterized by high recurrence rates and a dismal prognosis. The major improvement in the treatment of recurrent or metastatic gastric cancer in recent years has been the incorporation of trastuzumab, a monoclonal antibody that inhibits human epidermal growth factor receptor 2(HER2) heterodimerization, after the demonstrated predictive value of the overexpression and/or amplification of this receptor. Beyond HER2, other genetic abnormalities have been identified, and these mutations may be targetable by tyrosine kinase inhibitors or monoclonal antibodies. The demonstration of four distinct molecular subtypes of gastric cancer by the Cancer Genome Atlas study highlight the enormous heterogeneity of the disease and its complex interplay between genetic and epigenetic alterations and provide a roadmap to implement genome-guided personalized therapy in gastric cancer. In the present review, we aim to discuss, from a clinical point of view, the genomic landscape of gastric cancer described in recent studies, the therapeutic insights derived from these findings, and the clinical trials that have been conducted and those in progress that take into account tailored therapies for gastric cancer. | Alexandre A Jácome Anelisa K Coutinho Enaldo M Lima Aline C Andrade JoséSebastião dos Santos | 2016 | World Journal of Gastroenterology2016，22，3： | 2 |
| 2 | A mul- tiobjective modeling approach to locating incinerators 显示文摘 | Alada - Almeida L Coutinho - Rodrigues J Current J | 2009 | Socio -Economic Planning Sciences2009，，2： | 1 |
| 3 | The formation dissociation and electrical activity of divacancy-oxygen complexes in Si 显示文摘 | COUTINHO J JONES R OBERG S | 2003 | Physica B2003，，52： | 1 |
| 4 | Ultravoilet-B radiationand nitrogen effects on growth and yield of maize underMediterranean field condition显示文摘 | Correia C M Coutinho J F Bjom L 0 | 2000 | European Journal of Agronomy2000，12，： | 1 |
| 5 | Dynamic rheological analysisof the gelation behaviour of waxy crude oils显示文摘 | Lopes da Silva J A Coutinho JAP | 2004 | Rheologica Ac-ta2004，43，5： | 1 |
| 6 | Ultraviolet-B radiation and nitrogen effects on growth and yield of maize under Mediterranean field conditions显示文摘 | CARLOS M CORREIA C M COUTINHO J F BJORN L O SAGER E P S HUTCHINSON T C | 2000 | European Journal of Agronomy2000，，12： | 1 |
| 7 | Efficacy and limitations of triticale as a nitrogen catch crop in a mediterranean environment显示文摘 | Angelo Rodrigues M Coutinho J Fernando M | 2002 | European Journal of Agronomy2002，17，15： | 1 |
| 8 | Ultraviolet-B radiation and nitrogen affect the photosynthesis of maize : a Mediterranean field study 显示文摘 | Correia C M Moutinho-Pereira J M Coutinho J F | 2005 | European Journal of Agronomy2005，22，3： | 1 |
| 9 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 10 | Ultraviolet-B radiation and nitrogen effects on growth and yield of maize under Mediterranean field conditions显示文摘 | CORREIA C M COUTINHO J F BJORN L O TORRES J M G | 2000 | European Journal of Agronomy2000，12，2： | 1 |
| 11 | Measuring semantic similarity between Gene Ontology terms显示文摘 | Couto F M Silva M J and Coutinho P M | 2007 | Data & Knowledge Engineering2007，61，1： | 1 |
| 12 | Characterization of Sphaeropsis sapinea isolates from South Africa, Mexico, and Indonesia 显示文摘 | De Wet J Wingfield M J Coutinho T A | 2000 | Plant Disease2000，84，2： | 1 |
| 13 | Declining mortality in cerebral venous thrombosis:a systematic review显示文摘 | Coutinho JM Zuurbier SM Stam J | 2014 | Stroke2014，45，： | 1 |
| 14 | Second generation immune networks显示文摘 | Varela F J Coutinho A | 1991 | Immunol Today1991，12，5： | 1 |
| 15 | Analysis of the neuroligin 3and 4 genes in autism and other neuropsychiatric patients显示文摘 | Yan J Oliveira G Coutinho A | 2005 | MolPsychiatry2005，10，4： | 1 |
| 16 | Ultraviolet-B radiation and nitrogen af- fect the photosynthesis of maize: a mediterranean field ecosystem 显示文摘 | CORREIA C M MOUTINHO-PEREIRA J M COUTINHO J F | 2005 | European Journal of Agronomy2005，22，3： | 1 |
| 17 | Ultraviolet-B radiation and nitrogen affect the photosynthesis of maize:a mediterranean field study 显示文摘 | CARLOS M C MOUTINHO-PEREIRA J M COUTINHO J F | 2005 | European Journal of Agronomy2005，22，3： | 1 |
| 18 | Ionic liquid solutions as extractive solvents for value-added compounds from biomass显示文摘 | Passos H Freire M G Coutinho J A | 2014 | Green Chem2014，16，12： | 1 |
| 19 | Interactive spatial decision - support system for multiobjective hazardous ma- terials location - routing problems 显示文摘 | Coutinho -Rodrigues J Current J Cllmaco J | 1997 | Transportation Research Record:Journal of the Transportation Research Board1997，，1： | 1 |
| 20 | An evolving hierarchical family classification for glycosyltransferases 显示文摘 | Coutinho P M Deleury E Davies G J | 2003 | J Mol Biol2003，328，： | 1 |
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