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| 1 | Independent effects of diet and exercise training on fat oxidation in non-alcoholic fatty liver disease显示文摘AIM To investigate the independent effects of 6-mo of dietary energy restriction or exercise training on wholebody and hepatic fat oxidation of patients with nonalcoholic fatty liver disease(NAFLD).METHODS Participants were randomised into either circuit exercise training(EX;n = 13;3 h/wk without changes in dietary habits),or dietary energy restriction(ER) without changes in structured physical activity(ER;n = 8).Respiratory quotient(RQ) and whole-body fat oxidation rates(Fatox) were determined by indirect calorimetry under basal,insulin-stimulated and exercise conditions.Severity of disease and steatosis was determined by liver histology;hepatic Fatox was estimated from plasma β-hydroxybutyrate co.ncentrations;cardiorespiratory fitness was expressed as VO2 peak.Complete-case analysis was performed(EX:n = 10;ER:n = 6).RESULTS Hepatic steatosis and NAFLD activity score decreased with ER but not with EX.β-hydroxybutyrate concentrations increased significantly in response to ER(0.08 ± 0.02 mmol/L vs 0.12 ± 0.04 mmol/L,P = 0.03) but remained unchanged in response to EX(0.10 ± 0.03 mmol/L vs 0.11 ± 0.07 mmol/L,P = 0.39).Basal RQ decreased(P = 0.05) in response.to EX,while this change was not significant after ER(P = 0.38).VO_(2peak)(P < 0.001) and maximal Fa_(tox) during aerobic exercise(P = 0.03) improved with EX but not with ER(P > 0.05).The increase in β-hydroxybutyrate concentrations was correlated with the reduction in hepatic steatosis(r =-0.56,P = 0.04).CONCLUSION ER and EX lead to specific benefits on fat metabolism of patients with NAFLD.Increased hepatic Fat_(ox) in response to ER could be one mechanism through which the ER group achieved reduction in steatosis. | Ilaria Croci Nuala M Byrne Veronique S Chachay Andrew P Hills Andrew D Clouston Trisha M O'Moore-Sullivan Johannes B Prins Graeme A Macdonald Ingrid J Hickman | 2016 | World Journal of Hepatology2016，8，27： | 1 |
| 2 | Cyclosporin A pretreatment in a rat model of warm ischaemia/ reperfusion injury 显示文摘 | Saxton N E Barclay J L Clouston A D | 2002 | JHepatol2002，36，2： | 1 |
| 3 | Dangerous liaisons:The metabolic syndrome and nonalcoholic fatty liver disease显示文摘 | Powell E E Jonsson J R Clouston A D | 2005 | Ann Intern Med2005，143，10： | 1 |
| 4 | Steatosis inehronic hep- atitis C:association withinereased messengerRNA expression of collagen I, tumor necrosis factor - alphaand cytoc hrome P4502E1 显示文摘 | Gochee P A Jonsson J R Clouston N D | 2003 | J GastroenteroI Hepatol2003，18，4： | 1 |
| 5 | Steatosis and liver cell apoptosis in chronic hepatitis C: a mechanism for increased liver injury 显示文摘 | WALSH M J VANAGS D M CLOUSTON A D | 2004 | Hepatology2004，39，5： | 1 |
| 6 | Steatosis in chronic hepatitis C: association with increased messenger RNA expression of collagen I,tumor necrosis factor-alpha and cytochrome P450 2El显示文摘 | GOCHEE P A JONSSON J R CLOUSTON A D | 2003 | J Gastroenterol Hepatol2003，18，4： | 1 |
| 7 | Steatosis and chronic hepatitis C: analysis of fibrosis and stellate cell activation显示文摘 | Clouston A D Jonsson J R Purdie D M | 2001 | J Hepatol2001，34，2： | 1 |
| 8 | Interleukin- 32: a new proinflammatory cytokine involved in hepatitis C virus-related liver inflammation and fibrosis显示文摘 | MOSCHEN A R FRITZ T CLOUSTON A D | 2011 | Hepatology2011，53，6： | 1 |
| 9 | Links between hepatic fibrosis, ductular reaction, and progenitor显示文摘 | Williams M J Clouston A D Forbes S J | 2014 | Gastroenterology2014，146，2： | 1 |
| 10 | Parasitic origin of a solitary necrotic nodule of the liver显示文摘 | Clouston A D Walker N I Prociv P | 1993 | J Clin Pathol1993，46，： | 1 |
| 11 | Angiotensin-converting enzyme inhibition attenuates the progression of rat hepatic fibrosis显示文摘 | Jonsson J R Clouston A D Ando Y | 2001 | Gastroenterology2001，121，1： | 1 |
| 12 | Steatosis and liver cell apoptosis in hepatisis C:a mechanism for increased liver injury显示文摘 | WALSH M J VANAGS D M CLOUSTON A D | 2004 | Hepatology2004，39，5： | 1 |
| 13 | Interleukin-32:a new proinflammatory cytokine involved in hepatitis C virus-related liver inflammation andfibrosis显示文摘 | Moschen A R Fritz T Clouston A D | | 0，，06： | 1 |
| 14 | Inter-leukin-32 :a new proinflammatory cytokine involved inhepatitis C virus-related liver inflammation and fibrosis显示文摘 | MOSCHEN A R FRITZ T CLOUSTON A D | 2011 | Hepatology2011，53，6： | 1 |
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