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| 1 | Magnetic resonance imaging may predict deep remission in patients with perianal fistulizing Crohn's disease显示文摘AIM To evaluate the imaging course of Crohn's disease(CD) patients with perianal fistulas on long-term maintenance anti-tumor necrosis factor(TNF)-α therapy and identify predictors of deep remission.METHODS All patients with perianal CD treated with anti-TNF-α therapy at our tertiary care center were evaluated by magnetic resonance imaging(MRI) and clinical assessment. Two MR examinations were performed: at initiation of anti-TNF-α treatment and then at least 2 years after. Clinical assessment(remission, response and non-response) was based on Present's criteria. Rectoscopic patterns, MRI Van Assche score, and MRI fistula activity signs(T2 signal and contrast enhancement) were collected for the two MR examinations. Fistula healing was defined as the absence of T2 hyperintensity and contrast enhancement on MRI. Deep remission was defined as the association of both clinical remission, absence of anal canal ulcers and healing on MRI. Characteristics and imaging patterns of patients with and without deep remission were compared by univariate and multivariate analyses.RESULTS Forty-nine consecutive patients(31 females and 18 males) were included. They ranged in age from 14-70 years(mean, 33 years). MRI and clinical assessment were performed after a mean period of exposure to anti-TNF-α therapy of 40 ± 3.7 mo. Clinical remission, response and non-response were observed in 53.1%, 20.4%, and 26.5% of patients, respectively. Deep remission was observed in 32.7% of patients. Among the 26 patients in clinical remission, 10 had persisting inflammation of fistulas on MRI(T2 hyperintensity, n = 7; contrast enhancement, n = 10). Univariate analysis showed that deep remission was associated with the absence of rectal involvement and the absence of switch of anti-TNF-α treatment or surgery requirement. Multivariate analysis demonstrated that only the absence of rectal involvement(OR = 4.6; 95%CI: 1.03-20.5) was associated with deep remission.CONCLUSION Deep remission is achieved in approximately one third of patients on maintenance anti-TNF-α therapy. Absence of rectal involvement is predictive of deep remission. | Lucie Thomassin Laura Armengol-Debeir Cloé Charpentier Valerie Bridoux Edith Koning Guillaume Savoye Céline Savoye-Collet | 2017 | World Journal of Gastroenterology2017，23，23： | 5 |
| 2 | Serum amyloid P component and C-reactive protein mediate phagocytosis through murine FcγRs显示文摘 | Mold C Gresham H D Du Clos T W | 2001 | J Immunol2001，166，： | 2 |
| 3 | A study of nonblocking switching fabric networks 显示文摘 | C Clos | 1953 | BSTJ1953，32，5： | 1 |
| 4 | A study of nonblocking switching networks显示文摘 | Clos C | | 0，，02： | 1 |
| 5 | Analysis of the binding of C-reactive protein to chromatin subunits 显示文摘 | Du Clos TW Marnell L Zlock LR | 1991 | J Immunol1991，146，4： | 1 |
| 6 | The lattice stability of metals显示文摘 | Kaufman L Clo~gherty E X Weiss R J | 1963 | Acta Metall1963，11，： | 1 |
| 7 | Leishmaniaexosomes modulate innate and adaptive immune responsesthrough effects on monocytes and dendritic cells显示文摘 | Silverman JM Clos J Horakova E | 2010 | J Immunol2010，185，9： | 1 |
| 8 | A Study of Non-Blocking Switching Networks 显示文摘 | Clos C | 1953 | Bell Systems Technical Journal1953，，： | 1 |
| 9 | Function of C-reactive protein显示文摘 | Du Clos TW | 2000 | Ann Med2000，32，4： | 1 |
| 10 | The synthesis of biodegradable polymers with functional side chains显示文摘 | Cloing P G Zhoung W G | 1991 | J Polym Sci Polym Chem1991，24，17： | 1 |
| 11 | Function of C reactive protein显示文摘 | Du Clos TW | 2000 | Ann Med2000，32，2： | 1 |
| 12 | Function of C-reactive pro- tein显示文摘 | Du Clos TW | 2000 | Ann Med2000，32，4： | 1 |
| 13 | Regulation of complement activation by C-reactive protein显示文摘 | Mold C Gewurz H Du Clos T W | 1999 | Immunopharmacology1999，42，： | 1 |
| 14 | C-reactive protein as regulator of autoimmunity and in- flail mation显示文摘 | Du Clos TW | 2003 | Arthritis Rheum2003，48，6： | 1 |
| 15 | Effect d huprine X on :3-amyloid, synaptophysin and ct7 neuronal nicotinic acetyl- choline receptors in the brain of 3xTg-AD and APPswe trans- genic mice显示文摘 | Hedberg MM Clos MV Rafia M | 2010 | Neurodegener Dis2010，7，6： | 1 |
| 16 | Regulation of complement activationby C-reactiveprotein显示文摘 | Mold C Gewurz H Du Clos TW | 1999 | Immunopharmacology1999，42，13： | 1 |
| 17 | Function of C-reactive protein 显示文摘 | Du Clos TW | 2000 | Ann Med2000，32，： | 1 |
| 18 | Pentraxins : structure, function, and role in inflammation显示文摘 | Du Clos TW | 2013 | ISRN Inflarnm2013，2013，37： | 1 |
| 19 | Regulation of complement activation by c-reactive protein显示文摘 | Mold C Gewurz H Du Clos TW | 1999 | Immuno- phamacology1999，42，： | 1 |
| 20 | Regulation of complement activation by C- reactive protein显示文摘 | Mole C Gewurz H Du Clos TW | 1999 | Immunopharmacology1999，42，： | 1 |
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