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| 1 | Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis显示文摘The pool of microbes inhabiting our body is known as 'microbiota' and their collective genomes as 'microbiome'. The colon is the most densely populated organ in the human body, although other parts, such as the skin, vaginal mucosa, or respiratory tract, also harbour specific microbiota. This microbial community regulates some important metabolic and physiological functions of the host, and drives the maturation of the immune system in early life, contributing to its homeostasis during life. Alterations of the intestinal microbiota can occur by changes in composition(dysbiosis), function, or microbiota-host interactions and they can be directly correlated with several diseases. The only disease in which a clear causal role of a dysbiotic microbiota has been demonstrated is the case of Clostridium difficile infections. Nonetheless, alterations in composition and function of the microbiota have been associated with several gastrointestinal diseases(inflammatory bowel disease, colorectal cancer, or irritable bowel syndrome), as well as extra-intestinal pathologies, such as those affecting the liver, or the respiratory tract(e.g., allergy, bronchial asthma, and cystic fibrosis), among others. Species of Bifidobacterium genus are the normal inhabitants of a healthy human gut and alterations in number and composition of their populations is one of the most frequent features present in these diseases. The use of probiotics, including bifidobacteria strains, in preventive medicine to maintain a healthy intestinal function is well documented. Probiotics are also proposed as therapeutic agents for gastrointestinal disorders and other pathologies. The World Gastroenterology Organization recently published potential clinical applications for several probiotic formulations, in which species of lactobacilli are predominant. This review is focused on probiotic preparations containing Bifidobacterium strains, alone or in combination with other bacteria, which have been tested in human clinical studies. In spite of extensive literature on and research into this topic, the degree of scientific evidence of the effectiveness of probiotics is still insufficient in most cases. More effort need to be made to design and conduct accurate human studies demonstrating the efficacy of probiotics in the prevention, alleviation, or treatment of different pathologies. | Rafael Tojo Adolfo Suárez Marta G Clemente Clara G de los Reyes-Gavilán Abelardo Margolles Miguel Gueimonde Patricia Ruas-Madiedo | 2014 | World Journal of Gastroenterology2014，20，41： | 33 |
| 2 | Liver Planning Software Accurately Predicts Postoperative Liver Volume and Measures Early Regeneration显示文摘 | Amber L. Simpson David A. Geller Alan W. Hemming William R. Jarnagin Logan W. Clements Michael I. D’Angelica Prashanth Dumpuri Mithat G?nen Ivan Zendejas Michael I. Miga James D. Stefansic | 2014 | Journal of the American College of Surgeons2014，，： | 2 |
| 3 | A survey of overuse running injuries显示文摘 | CLEMENT D B TAUNTON J E SMART G W | 1981 | Phy Sports Med1981，9，： | 1 |
| 4 | Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain-a primate study显示文摘 | Hynynen K McDannold N Clement G | 2006 | Eur J Radiol2006，59，2： | 1 |
| 5 | Adaptive changes in perception of body orientation and mental image rotation in microgravity显示文摘 | Berthoz A Lestienne F | 1987 | Aviat Space Environ Med1987，58，9： | 1 |
| 6 | Targeting the Wnt signaling pathway to treat Barrett's esophagus 显示文摘 | Clement G Jablons DM Benhattar J | 2007 | Expert Opin Ther Targets2007，11，3： | 1 |
| 7 | Interpretation of Remotely-Sensed Images in a Context of Muhisensor Fusion Using a Muhispecialist Architecture 显示文摘 | CLEMENT V GIRAUDON G HOUZELLE S | 1993 | Ieee T Geosci Remote1993，31，4： | 1 |
| 8 | Allergy to bovine beta-lactoglobulin:specificity of human IgE to tryptic peptides 显示文摘 | SELO I CLEMENT G BERNARD H | 1999 | Clin Exp Allergy1999，29，8： | 1 |
| 9 | Direct stimulatory effect of insulin-like growth factor I on monocyte and macrophage tumor necrosis-a production显示文摘 | Renier G Clement I Desfaits AC | 1996 | Endocrinology1996，137，11： | 1 |
| 10 | Ultrasonic determination of the composition of a meat-based product显示文摘 | Simal S Benedito J Clemente G | 2003 | Journal of Food Engineering2003，58，3： | 1 |
| 11 | Age-related changes in cortical porosity of the midshaft of the human femur 显示文摘 | Feik S A Thomas C D Clement J G | 1997 | J Anat1997，191，3： | 1 |
| 12 | Single and combined effects of sediment-associated PAHs on three species of freshwater macroinvertebrates显示文摘 | Verrhiest G Clement B Blake G | 2001 | Ecotoxicology2001，10，6： | 1 |
| 13 | ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome显示文摘 | Liu G Clement L C Kanwar Y S | 2006 | J Biol Chem2006，281，39： | 1 |
| 14 | ^31P Labeled cyclic nitrones:a new class of spin traps for free radicals in biological milieu显示文摘 | Barbati S Clement J L Olive G | 1997 | Free Radicals in Biology and Environment1997，，： | 1 |
| 15 | Is more better? An analysis of hospital outcomes and efficiency with a DEA model of output con- gestion 显示文摘 | Clement J Valdmanis V Bazzoli G Zhao M Chukmaitov A | 2008 | Health Care Management Science2008，11，： | 1 |
| 16 | Microglandular adenosis of the breast:a lesion simulating tubular carcinoma显示文摘 | Clement P B Azzopardi J G | 1983 | Histopathology1983，7，2： | 1 |
| 17 | Epigenetic alteration of the Writ inhibitory factor-1 promoter occurs early in the carcinogenesis of Barrett's esophagus 显示文摘 | Clement G Guilleret I He B | 2008 | Cancer Sci2008，99，1： | 1 |
| 18 | What do we want and what do we get from not-for-profit hospitals 显示文摘 | Clement Jan p Smith Dean G Wheeler John R C | 1994 | Hospital & Health Services Administration1994，39，2： | 1 |
| 19 | Direct stimulatory effect of insulin-like growth factor I on monocyte and macrophage tumor necrosis-a production显示文摘 | Renier G Clement I Desfaits AC | 1996 | Endocrinol1996，137，： | 1 |
| 20 | Brand values and capital market valuation 显示文摘 | Barth M Clement M Foster G | 1998 | Review of Accounting Studues1998，3，： | 1 |
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