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| 1 | Incidence of gallstone disease in Italy:Results from a multicenter,population-based Italian study (the MICOL project)显示文摘AIM:To evaluate gallstone incidence and risk factors in a large population-based study. METHODS: Gallstone incidence and risk factors, were evaluated by structured questionnaire and physical examination, respectively, in 9611 of 11 109 (86.5%) subjects who were gallstone-free at the cross-sectional study. RESULTS: Six centers throughout Italy enrolled 9611 subjects (5477 males, 4134 females, aged 30-79 years), 9517 of whom were included into analysis: 424 subjects (4.4%) had gallstones and 61 (0.6%) had been cholecystectomized yielding a cumulative incidence of 0.67% per year (0.66% in males, 0.81% in females). Increasing age, a high body mass index (BMI), a history of diabetes, peptic ulcer and angina, and low cholesterol and high triglyceride levels were identifi ed as risk factors in men while, in females, the only risk factors were increasing age and a high BMI.Increasing age and pain in the right hypocondrium in men and increasing age in females were identifi ed as predictors of gallstones. Pain in the epigastrium/ right hypocondrium was the only symptom related to gallstones; furthermore, some characteristics of pain (forcing to rest, not relieved by bowel movements) were significantly associated with gallstones. No correlation was found between gallstone characteristics and clinical manifestations, while increasing age in men and increasing age and BMI in females were predictors of pain. CONCLUSION:Increasing age and BMI represent true risk factors for gallstone disease (GD); pain in the right hypocondrium and/or epigastrium is confi rmed as the only symptom related to gallstones. | Davide Festi Ada Dormi Simona Capodicasa Tommaso Staniscia Adolfo F Attili Paola Loria Paolo Pazzi Giuseppe Mazzella Claudia Sama Enrico Roda Antonio Colecchia | 2008 | World Journal of Gastroenterology2008，14，34： | 23 |
| 2 | Non-alcoholic fatty liver disease and diabetes: From physiopathological interplay to diagnosis and treatment显示文摘Non-alcoholic fatty liver disease(NAFLD)is highly prevalent in patients with diabetes mellitus and increasing evidence suggests that patients with type 2diabetes are at a particularly high risk for developing the progressive forms of NAFLD,non-alcoholic steatohepatitis and associated advanced liver fibrosis.Moreover,diabetes is an independent risk factor for NAFLD progression,and for hepatocellular carcinoma development and liver-related mortality in prospective studies.Notwithstanding,patients with NAFLD have an elevated prevalence of prediabetes.Recent studies have shown that NAFLD presence predicts the development of type2 diabetes.Diabetes and NAFLD have mutual pathogenetic mechanisms and it is possible that genetic and environmental factors interact with metabolic derangements to accelerate NAFLD progression in diabetic patients.The diagnosis of the more advanced stages of NAFLD in diabetic patients shares the same challenges as in non-diabetic patients and it includes imaging and serological methods,although histopathological evaluation is still considered the gold standard diagnostic method.An effective established treatment is not yet available for patients with steatohepatitis and fibrosis and randomized clinical trials including only diabetic patients are lacking.We sought to outline the published data including epidemiology,pathogenesis,diagnosis and treatment of NAFLD in diabetic patients,in order to better understand the interplay between these two prevalent diseases and identify the gaps that still need to be fulfilled in the management of NAFLD in patients with diabetes mellitus. | Nathalie C Leite Cristiane A Villela-Nogueira Claudia R L Cardoso Gil F Salles | 2014 | World Journal of Gastroenterology2014，20，26： | 21 |
| 3 | Modification of tubular chitosan-based peripheral nerve implants: applications for simple or more complex approaches显示文摘Surgical treatment of peripheral nerve injuries is still a major challenge in human clinic.Up to now,none of the well-developed microsurgical treatment options is able to guarantee a complete restoration of nerve function.This restriction is also effective for novel clinically approved artificial nerve guides.In this review,we compare surgical repair techniques primarily for digital nerve injuries reported with relatively high prevalence to be valuable attempts in clinical digital nerve repair and point out their advantages and shortcomings.We furthermore discuss the use of artificial nerve grafts with a focus on chitosan-based nerve guides,for which our own studies contributed to their approval for clinical use.In the second part of this review,very recent future perspectives for the enhancement of tubular(commonly hollow)nerve guides are discussed in terms of their clinical translatability and ability to form three-dimensional constructs that biomimick the natural nerve structure.This includes materials that have already shown their beneficial potential in in vivo studies like fibrous intraluminal guidance structures,hydrogels,growth factors,and approaches of cell transplantation.Additionally,we highlight upcoming future perspectives comprising co-application of stem cell secretome.From our overview,we conclude that already simple attempts are highly effective to increase the regeneration supporting properties of nerve guides in experimental studies.But for bringing nerve repair with bioartificial nerve grafts to the next level,e.g.repair of defects>3 cm in human patients,more complex intraluminal guidance structures such as innovatively manufactured hydrogels and likely supplementation of stem cells or their secretome for therapeutic purposes may represent promising future perspectives. | Nina Dietzmeyer Maria F?rthmann Claudia Grothe Kirsten Haastert-Talini | 2020 | Neural Regeneration Research2020，15，8： | 4 |
| 4 | Dyslipidemia: evidence of efficacy of the pharmacological and non-pharmacological treatment in the elderly显示文摘为心血管的疾病(CVD ) 控制风险因素在的临床的决定老考虑下列:(1 ) 老预期寿命;(2 ) 老生物年龄和功能的能力;(3 ) 在老组的心血管的疾病的角色;(4 ) 风险因素在的流行老;并且(5 ) 风险因素在的治疗的有效性老。很多研究显示出 dyslipidemia 的第二等、主要的预防的功效在老。然而,在 80 年包括了病人的唯一的审判是心保护学习(HPS ) 。Statins 为阴沉的低密度的脂蛋白胆固醇(LDL-C ) 被认为第一线治疗。因为生活方式变化是很困难的完成,医生们一般来说趋于开许多药控制心血管的风险因素。然而,健康食物消费在主要、第二等的心血管的预防仍然是一块奠基石并且应该被每个人实现。 | Claudia F Gravina Marcelo Bertolami Giselle HP Rodrigues | 2012 | Journal of Geriatric Cardiology2012，9，2： | 3 |
| 5 | The spectrum of neuromyelitis optica显示文摘 | Dean M Wingerchuk Vanda A Lennon Claudia F Lucchinetti Sean J Pittock Brian G Weinshenker | 2007 | Lancet Neurology2007，，9： | 3 |
| 6 | Genetic ancestry analysis in non-alcoholic fatty liver disease patients from Brazil and Portugal显示文摘AIM:To study the association between genetic ancestry,non-alcoholic fatty liver disease(NAFLD) metabolic characteristics in two cohorts of patients,from Brazil and Portugal. METHODS:We included 131 subjects from Brazil [(n = 45 with simple steatosis(S. Steatosis) and n = 86 with nonalcoholic steatohepatitis(NASH)] and 90 patients from Portugal(n = 66,S. Steatosis; n = 24,NASH). All patients had biopsy-proven NAFLD. In histologic evaluation NAFLD activity score was used to assess histology and more than 5 points defined NASH in this study. Patients were divided into two groups according to histology diagnosis:simple steatosis or non-alcoholic statohepatitis. Genetic ancestry was assessed using real-time polymerase chain reaction. Seven ancestry informative markers(AT3-I/D,LPL,Sb19.3,APO,FYNull,PV92,and CKMM) with the greatest ethnicgeographical differential frequencies(≥ 48%) were used to define genetic ancestry. Data were analyzed using R PROJECTS software. Ancestry allele frequencies between groups were analyzed by GENEPOP onlineand the estimation of genetic ancestry contribution was evaluated by ADMIX-95 software. The 5% alpha-error was considered as significant(P < 0.05). RESULTS:In the Brazilian sample,NASH was significantly more frequent among the elderly patients with diabetes(NASH 56 ± 1.1 years old vs S. Steatosis 51 ± 1.5 years old,P = 3.7 x 10-9),dyslipidemia(NASH 63% vs S. Steatosis 37%,P = 0.009),higher fasting glucose levels(NASH 124 ± 5.2 vs S. Steatosis 106 ± 5.3,P = 0.001) and Homeostatic Model of Assessment index > 2.5 [NASH 5.3(70.8%) vs S. Steatosis 4.6(29.2%) P = 0.04]. In the Portuguese study population,dyslipidemia was present in all patients with NASH(P = 0.03) and hypertension was present in a larger percentage of subjects in the S. Steatosis group(P = 0.003,respectively). The genetic ancestry contribution among Brazilian and Portuguese individuals with NASH was similar to those with S. Steatosis from each cohort(Brazilian cohort:P = 0.75; Portuguese cohort:P = 0.97). Nonetheless,the genetic ancestry contribution of the Brazilian and Portuguese population were different,and a greater European and Amerindian ancestry contribution was detected in the Portuguese population while a higher African genetic ancestry contribution was observed in Brazilian population of both NASH and S. Steatosis groups.CONCLUSION:There was no difference between the genetic ancestry contribution among Brazilian and Portuguese individuals with NASH and S. Steatosis from each cohort. | Lourianne Nascimento Cavalcante Jose Tadeu Stefano Mariana V Machado Daniel F Mazo Fabiola Rabelo Kiyoko Abe Sandes Flair Jose Carrilho Helena Cortez-Pinto Andre Castro Lyra Claudia P de Oliveira | 2015 | World Journal of Hepatology2015，7，10： | 2 |
| 7 | Determination of water-soluble hexavalent chromium in clinker samples bywavelength-dispersive x-ray fluorescence spectrometry after concentration in activated layers显示文摘 | Eva M Claudia F S Marta T | 2010 | Applied Spectroscopy2010，64，： | 1 |
| 8 | Role of infectious and immune factors in coronary and cerebrovascular arteriosclerosis 显示文摘 | Claudia St Liberger Josef F | 2002 | Clin Diagn Lab lmmunol2002，9，2： | 1 |
| 9 | Atetrahyrdroprotoberberine alkaloid from Croton kemiargyreus 显示文摘 | Ana Claudia F Amaral Roderick A Barnes | 1998 | Phytochemsitry1998，47，7： | 1 |
| 10 | Liposomes as in vivo carriers for citicoline:Effects on rat cerebral post-ischaemic reperfusion 显示文摘 | Massimo F Giovanni P Claudia DG | 1994 | J Pharm Pharmacol1994，46，： | 1 |
| 11 | Results of a laboratory experiment relating spectral reflectance to total suspended solids显示文摘 | Carlos A S Evlyn M L Claudia Z F B | 1991 | Remote Sensing of Environment1991，36，： | 1 |
| 12 | Chemosensitivity of solid tumor cells in vitro is related to activation of the Fas system 显示文摘 | Marek L Claudia F | 1998 | Int J Cancer1998，76，1： | 1 |
| 13 | Fre- quency of duplications in the D-loop in patients with mi- tochondrial DNA deletions 显示文摘 | CELIA H T CLAUDIA F B MARINA C | 2002 | Biochimica et Biophysi- ca Acta (BBA) -Molecular Basis of Disease2002，1588，1： | 1 |
| 14 | Lipotoxicity: Effects of Dietary Saturated and Transfatty Acids显示文摘 | Débora Estadella Claudia M. da Penha Oller do Nascimento Lila M. Oyama Eliane B. Ribeiro Ana R. Damaso Aline de Piano Fábio Santos Lira | 2013 | Mediators of Inflammation2013，，： | 1 |
| 15 | Growth hormone deficiency and recombinant hGH(rhGH)replacement in children with idiopathic isolated GH deficiency:effects on the hypothalamus-pituitary-adrenal axis显示文摘 | Silvia B Claudia G Emanuele F | 2007 | Endocrin Abstracts2007，14，： | 1 |
| 16 | The Homecoming of American College Women:the Reversal of the College Gender Gap显示文摘 | Goldin Claudia Katz Lawrence F Kuziemko Ilyana | 2006 | Journal of Economic Perspectives2006，20，04： | 1 |
| 17 | A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis显示文摘 | Vanda A Lennon Dean M Wingerchuk Thomas J Kryzer Sean J Pittock Claudia F Lucchinetti Kazuo Fujihara Ichiro Nakashima Brian G Weinshenker | 2004 | 2004 (9451)2004，，9451： | 1 |
| 18 | Electrophoretic analysis(tricine-SDS-PAGE)of bovine caseins显示文摘 | Marcelo F P Claudia L N | 2002 | Acta Farma-ceutic Bonaerense2002，21，1： | 1 |
| 19 | Purification and characterization of lectin from seed of Vatairea macrocarpa dule 显示文摘 | Benldo S C Claudia F S Thalles B G | 1998 | Phytochemistry1998，49，3： | 1 |
| 20 | Cortical demyelination and diffuse white matter injury in multiple sclerosis 显示文摘 | Kutzelnigg Alexandra Lucchinetti Claudia F Stadelmann Christine | 2005 | Brain2005，128，11： | 1 |
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