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| 1 | Long-term outcome and prognostic factors of patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the long-term outcome and prognostic factors of patients with hilar cholangiocarinoma. METHODS: Ninety-six consecutive patients underwent treatment for malignant hilar bile duct tumors during 1995–2005. Of the 96 patients, 20 were initially treated with surgery (n = 2 R0 / n = 18 R1). In non-operated patients, data analysis was performed retrospectively. RESULTS: Among the 96 patients, 76 were treated with endoscopic transpapillary (ERC, n = 45) and/or percutaneous transhepatic biliary drainage (PTBD, n = 31). The mean survival time of these 76 patients undergoing palliative endoscopic and/or percutaneous drainage was 359 ± 296 d. The mean survival time of patients with initial bilirubin levels > 10 mg/dL was significantly lower (P < 0.001) than patients with bilirubin levels < 10 mg/dL. The mean survival time of patients with Bismuth stage Ⅱ (n = 8), Ⅲ (n = 28) and Ⅳ (n = 40) was 496 ± 300 d, 441 ± 385 d and 274 ± 218 d, respectively. Thus, patients with advanced Bismuth stage showed a reduced mean survival time, but the difference was not significant. The type of biliary drainage had no significant beneficial effect on the mean survival time (ERC vs PTBD, P = 0.806). CONCLUSION: Initial bilirubin level is a significant prognostic factor for survival of patients. In contrast, age, tumor stage according to the Bismuth-Corlette classification, and types of intervention are not significant prognostic parameters for survival. Palliative treatment with endoscopic or percutaneous biliary drainage is still suboptimal, new diagnostic and therapeutic tools need to be evaluated. | Andreas Weber Sonja Landrock Jochen Schneider Manfred Stangl Bruno Neu Peter Born Meinhard Classen Thomas Rsch Roland M Schmid Christian Prinz | 2007 | World Journal of Gastroenterology2007，13，9： | 23 |
| 2 | In vitro techniques for the assessment of neurotoxicity 显示文摘 | Harry GJ Billingsley M Bruinink A Campbell IL Classen W Dorman DC | 1998 | Environ Health Perspect1998，106，1： | 1 |
| 3 | Endoskpische sphincterotomie der papilla Vateri und stainextrakion aus ductus choledochus 显示文摘 | Classen M Demling L | 1974 | Dtsch Med Wochenschr1974，99，： | 1 |
| 4 | Endoscopic ultrasonographyin the evaluation of colon and rectal disease 显示文摘 | Rosch T Lorenz R Classen M | 1990 | Gastrointestinal Endoscopy1990，36，2： | 1 |
| 5 | Endoscopic sphincterotomy of the papilla of vater and extraction of stones from the chole?dochal duct (author's transl )显示文摘 | CLASSEN M D | 1974 | Dtsch Med Wochenschr1974，99，： | 1 |
| 6 | The Wigner distribution-a tool for time-frequency signal analysis, part Ⅰ : continuous-time signals显示文摘 | Classen T A C M Mecldenbrauker W F G | 1980 | Philips J Res1980，35，： | 1 |
| 7 | The effect of pelleting, salt, and pentosanase on the viscosity of intestinal contents and the performance of broilers fed rye显示文摘 | Bedford M R Classen H L | 1991 | Poultry Sci1991，70，： | 1 |
| 8 | Preoperative pancreatic diagnosis using duodenoscopy显示文摘 | Classen M Demling L | 1972 | German Chirurg1972，43，6： | 1 |
| 9 | Reduction of intestinal viscosity through manipulation of dietary rye and pentosanase concentration effeeted growth rate and food conversion efficiency of broiler chicken显示文摘 | Bedford M R Classen H L | 1992 | Nutr1992，122，： | 1 |
| 10 | Self Expanding Metal Stents Versus Conventional Plastic Endoprostheses for Malignant Biliary Obstruction显示文摘 | Neuhaus H Hagenmuller F Classen M | 1991 | Gastrointest Endosc1991，29，6： | 1 |
| 11 | ATP hydrolysis by oschemic mitochondria显示文摘 | Classen J Mergner W Costa M | 1989 | Cell Physiol1989，141，1： | 1 |
| 12 | Complications of diagnostic gastrointestinal endoscopy显示文摘 | Hart R Classen M | 1990 | Endoscopy1990，22，22： | 1 |
| 13 | An in vitro assay for prediction of broiler intestinal viscosity and growth when fed rye-based diets in the presence of exogenous enzyme显示文摘 | Bedford M R and Classen H L | 1993 | Poultry Sci1993，72，： | 1 |
| 14 | Endoscopic ultrasonographyin the evaluation of colon and rectal disease 显示文摘 | RSsch T Lorenz R Classen M | 1990 | Gastrointest En- dosc1990，36，2： | 1 |
| 15 | diagnostic lapaoscopy,let,s doit again显示文摘 | Classen M Zillinger C Frimberger E | 1999 | Gastroin testinal Endosc1999，50，2： | 1 |
| 16 | Complications of diagnostic gastrointestinal endoscopy显示文摘 | Hart R Classen M | 1990 | Endoscopy1990，22，5： | 1 |
| 17 | Cubic function between increasing dietary magnesium levels and the magnesium concen- tration of serum and bone in young rats显示文摘 | Classen H Fischer G Moschlin M | 1983 | Magnesium1983，2，46： | 1 |
| 18 | Radiotherapy alone in technically operable ,medically inoperable ,early stage( Ⅰ/Ⅱ ) non-small cell lung cancer显示文摘 | Classen J Bamberg M | 2002 | Int J Radiat Oncol Biol Phys2002，54，： | 1 |
| 19 | Evalu- ating the effects of organic carbon on biological filtration performance in a large scale recirculating aquaculture system显示文摘 | GUERDAT T C LOSORDO T M CLASSEN J J | 2011 | AquaculturaI Engineering2011，44，1： | 1 |
| 20 | The effect of pellet- ing, salt, and pentosanase on the viscosity of intestinal contents and the performance of broilers fed rye 显示文摘 | Bedford M R Classen H L Campbell G L | 1991 | Poultry Sci1991，70，： | 1 |
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