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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Why the Western Pacific Subtropical High Has Extended Westward since the Late 1970s显示文摘 | Zhou Tianjun Yu Rucong Zhang Jie Drange Helge Cassou Christophe Deser Clara Hodson Daniel L R Sanchez-Gomez Emilia Li Jian Keenlyside Noel Xin Xiaoge Okumura Yuko | 2009 | Journal of Climate2009，，8： | 2 |
| 3 | Establishment of a Cre/loxP recombination system for N-terminal epitope tag- ging of genes in Tetrahymena显示文摘 | Clara J L Busch M Alexander V | 2010 | Microbiol2010，10，46： | 1 |
| 4 | Delayed inhibition ofangiotensin II receptor type 1 reduces secondary brain da-mage and improves unctional recovery after experimentalbrain trauma 显示文摘 | Ralph TK Sebastian W Clara L | 2012 | Crit Care Med2012，40，1： | 1 |
| 5 | Spatially-resolved EELS analysis of antibody distribution on biofunctionalized magnetic nanoparticles显示文摘 | Raul A Laura D M Laura C Alvaro M Marcel T Valeria G Jesus M D L F Clara M Ricardo 1 | 2013 | ACS Nano2013，7，5： | 1 |
| 6 | Coronary dyncs and mental arithmetic stress in human 显示文摘 | L' Abbate A Simonetti I Carpeggiani Clara | 1991 | Circulation1991，83，： | 1 |
| 7 | Delayed inhibition of angiotensin II receptortype 1 reduces secondary brain damage and improves unctional recovery afterexperimental brain trauma显示文摘 | TK Ralph W Sebastian L Clara | 2012 | Critical Care Medicine2012，40，3： | 1 |
| 8 | Hughes, Cobalt chloride,a hypoxia-mimicking agent,targets sterol synthesis in the pathogenic fungus Cryptococcus neofor- mans显示文摘 | Hyeseung Lee Clara M Bien Adam L | 2007 | Molecular Microbiology2007，65，4： | 1 |
| 9 | Coronary dyncs and mental arithmetic stress in human显示文摘 | L'Abbate A Simonetti I Carpeggiani Clara | 1991 | Circulation1991，83，： | 1 |
| 10 | Effect of cholecystokinin-A receptor blockade on postprandial insulinaemia and gastric emptying in humans显示文摘 | Hidalgo L Clara P Estorch M | 2002 | Neurogastroenterol Motil2002，14，5： | 1 |
| 11 | Treatment of arte- riovenous haemodialysis graft thrombosis associated to venous anastomotic stenosis by surgical thrombecto- my, covered stenting and high-pressure angioplasty显示文摘 | Calsina L Clara A Collado S | 2013 | Nefrologia2013，33，： | 1 |
| 12 | 显示文摘 | Clara Goncalves M Fortes L M Almeida R M | 2009 | Optial Materials2009，31，： | 1 |
| 13 | Measuring quality of life of Chinese cancer patients显示文摘 | Clara L M Yu Richard Fielding Cecelia L W Chan | 2000 | Cancer2000，88，7： | 1 |
| 14 | Brodifacoumpoisoning with toxicokinetic data显示文摘 | Valentina O Biochem Clara M L | 2007 | Clinical Toxicology2007，45，： | 1 |
| 15 | via somatic embryogenesis 显示文摘 | Dai J L Tan X Zhan Y G et aL Rapid and repetitive plant regeneration of Aralia clara Seem | 2011 | Plant Cell Tiss Org Cult2011，104，1： | 1 |
| 16 | Synthetic grafts for anterior cruciate ligament rupture: 19-year outcome study 显示文摘 | Alberto V Clara T Claudio L | 2010 | The Knee2010，2，： | 1 |
| 17 | Characterization and activity studies of highly heavy metal resistant sulphate-reducing bacteria to be used in acid mine drainage decontamination显示文摘 | Mónica Martins M. Leonor Faleiro Raúl J. Barros A. Raquel Veríssimo M. Alexandra Barreiros M. Clara Costa | 2008 | Journal of Hazardous Materials2008，，2： | 1 |
| 18 | Relation Between The 6-Minute Walk Test And The Maximum Oxygen Consumption 显示文摘 | Walter V Clara L Luis F | 2007 | Chest Meeting Abstracts2007，，132： | 1 |
| 19 | Development of a solid- phase extraction liquid chromatography-tandem mass spectrometry method for benzotrlazoles and benzothiazoles in wastewater and re- cycled water显示文摘 | Clara H L Francesco B Kathryn L L | 2013 | J Chromatogr A2013，1299，： | 1 |
| 20 | TheAFHSC-Division of GEIS Operations Predictive Surveillance Pro-gram :a multidisciplinary approach for the early detection and re-sponse to disease outbreaks 显示文摘 | Clara J Witt Allen L Richards Penny M Masuoka | 2011 | BMC Public Health2011，11，2： | 1 |
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