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| 1 | Role of endoscopic ultrasonography in the loco-regional staging of patients with rectal cancer显示文摘The prognosis of rectal cancer(RC) is strictly related to both T and N stage of the disease at the time of diagnosis. RC staging is crucial for choosing the best multimodal therapy: patients with high risk locally advanced RC(LARC) undergo surgery after neoadjuvant chemotherapy and radiotherapy(NAT); those with low risk LARC are operated on after a preoperative short-course radiation therapy; finally, surgery alone is recommended only for early RC. Several imaging methods are used for staging patients with RC: computerized tomography, magnetic resonance imaging, positron emission tomography, and endoscopic ultrasound(EUS). EUS is highly accurate for the loco-regional staging of RC, since it is capable to evaluate precisely the mural infiltration of the tumor(T), especially in early RC. On the other hand, EUS is less accurate in restaging RC after NAT and before surgery. Finally, EUS is indicated for follow-up of patients operated on for RC, where there is a need for the surveillance of the anastomosis. The aim of this review is to highlight the impact of EUS on the management of patients with RC, evaluating its role in both preoperative staging and follow-up of patients after surgery. | Pietro Marone Mario de Bellis Valentina D'Angelo Paolo Delrio Valentina Passananti Elena Di Girolamo Giovanni Battista Rossi Daniela Rega Maura Claire Tracey Alfonso Mario Tempesta | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，7： | 11 |
| 2 | Identification and characterization of genes that control fat deposition in chickens显示文摘Background: Fat deposits in chickens contribute significantly to meat quality attributes such as juiciness, flavor,taste and other organoleptic properties. The quantity of fat deposited increases faster and earlier in the fastgrowing chickens than in slow-growing chickens. In this study, Affymetrix Genechip? Chicken Genome Arrays 32773transcripts were used to compare gene expression profiles in liver and hypothalamus tissues of fast-growing and slow-growing chicken at 8 wk of age. Real-time RT-PCR was used to validate the differential expression of genes selected from the microarray analysis. The mRNA expression of the genes was further examined in fat tissues. The association of single nucleotide polymorphisms of four lipid-related genes with fat traits was examined in a F2resource population.Results: Four hundred genes in the liver tissues and 220 genes hypothalamus tissues, respectively, were identified to be differentially expressed in fast-growing chickens and slow-growing chickens. Expression levels of genes for lipid metabolism(SULT1B1, ACSBG2, PNPLA3, LPL, AOAH) carbohydrate metabolism(MGAT4B, XYLB, GBE1, PGM1,HKDC1)cholesttrol biosynthesis(FDPS, LSS, HMGCR, NSDHL, DHCR24, IDI1, ME1) HSD17B7 and other reaction or processes(CYP1A4, CYP1A1, AKR1B1, CYP4V2, DDO) were higher in the fast-growing White Recessive Rock chickens than in the slow-growing Xinghua chickens. On the other hand, expression levels of genes associated with multicellular organism development, immune response, DNA integration, melanin biosynthetic process, muscle organ development and oxidation-reduction(FRZB, DMD, FUT8, CYP2C45, DHRSX, and CYP2C18) and with glycol-metabolism(GCNT2, ELOVL 6, and FASN), were higher in the XH chickens than in the fast-growing chickens. RT-PCR validated high expression levels of nine out of 12 genes in fat tissues. The G1257069A and T1247123C of the ACSBG2 gene were significantly associated with abdominal fat weight. The G4928024A of the FASN gene were significantly associated with fat bandwidth, and abdominal fat percentage. The C4930169T of the FASN gene was associated with abdominal fat weight while the A59539099G of the ELOVL 6 was significantly associated with subcutaneous fat. The A8378815G of the DDT was associated with fat band width.Conclusion: The differences in fat deposition were reflected with differential gene expressions in fast and slow growing chickens. | Hirwa Claire D'Andre Wallace Paul Xu Shen Xinzheng Jia Rong Zhang Liang Sun Xiquan Zhang | 2014 | Journal of Animal Science and Biotechnology2014，5，1： | 7 |
| 3 | Imaging of liver cancer显示文摘Improvements in imaging technology allow exploitation of the dual blood supply of the liver to aid in the identif ication and characterisation of both malignant and benign liver lesions. Imaging techniques available include contrast enhanced ultrasound, computed tomography and magnetic resonance imaging. This review discusses the application of several imaging techniques in the diagnosis and staging of both hepatocellular carcinoma and cholangiocarcinoma and outlines certain characteristics of benign liver lesions. The advantages of each imaging technique are highlighted, while underscoring the potential pitfalls and limitations of each imaging modality. | Ben Ariff Claire R Lloyd Sameer Khan Mohamed Shariff Andrew V Thillainayagam Devinder S Bansi Shahid A Khan Simon D Taylor-Robinson Adrian KP Lim | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
| 4 | Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1 receptors in a rat model of Parkinson’s disease显示文摘To date there is no treatment able to stop or slow down the loss of dopaminergic neurons that characterizes Parkinson’s disease.It was recently observed in a rodent model of Alzheimer’s disease that the interaction between the α7 subtype of nicotinic acetylcholine receptor(α7-nAChR)and sigma-1 receptor(σ1-R)could exert neuroprotective effects through the modulation of neuroinflammation which is one of the key components of the pathophysiology of Parkinson’s disease.In this context,the aim of the present study was to assess the effects of the concomitant administration of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide(PHA)543613 as an α7-nAChR agonist and 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate(PRE)-084 as aσ1-R agonist in a well-characterized 6-hydroxydopamine rat model of Parkinson’s disease.The animals received either vehicle separately or the dual therapy PHA/PRE once a day until day 14 postlesion.Although no effect was noticed in the amphetamine-induced rotation test,our data has shown that the PHA/PRE treatment induced partial protection of the dopaminergic neurons(15-20%),assessed by the dopamine transporter density in the striatum and immunoreactive tyrosine hydroxylase in the substantia nigra.Furthermore,this dual therapy reduced the degree of glial activation consecutive to the 6-hydroxydopamine lesion,i.e,the 18 kDa translocation protein density and glial fibrillary acidic protein staining in the striatum,and the CD11b and glial fibrillary acidic protein staining in the substantia nigra.Hence,this study reports for the first time that concomitant activation of α7-nAChR andσ1-R can provide a partial recovery of the nigro-striatal dopaminergic neurons through the modulation of microglial activation.The study was approved by the Regional Ethics Committee(CEEA Val de Loire n°19)validated this protocol(Authorization N°00434.02)on May 15,2014. | Steven Vetel Laura Foucault-Fruchard Claire Tronel Frédéric Buron Jackie Vergote Sylvie Bodard Sylvain Routier Sophie Sérrière Sylvie Chalon | 2021 | Neural Regeneration Research2021，16，6： | 3 |
| 5 | Consensus on the definition of colorectal anastomotic leakage: A modified Delphi study显示文摘BACKGROUND Despite the emerging knowledge about colorectal anastomotic leakage(CAL)through the increasing number of clinical and experimental studies, there is no generally accepted definition of CAL. Because of the wide variety of definitions used in literature, comparison of study outcomes and quality of care is complicated.AIM To reach consensus on the definition of CAL using a modified Delphi method.METHODS The RAND/UCLA appropriateness method was used. The expert panel consisted of international colorectal surgeons and researchers who had published three or more articles about CAL. The consensus process consisted of two online distributed questionnaires and a third round with a recommendation. In the questionnaires participants were asked to rate the appropriateness of statements using a 1-9 Likert scale. Consensus was defined as a panel median between 1-3 or 7-9 without disagreement. In the final round a recommendation was formed regarding the definition of CAL and the expert panel was asked if they agreed or disagreed.RESULTSTwenty-three authors participated in the first round and twenty-one finished the second round. After two rounds consensus was reached on 37 items(80%) in nine different categories. The International Study Group of Rectal Cancer definition is the most frequently advised general definition by our panel. Consensus was reached regarding the clinical symptoms of CAL, which serum markers contributes to the suspicion of CAL, which radiological and perioperative findings should be considered as CAL, which grading system is appropriate and if there should be a range of postoperative days in the definition. Eventually, 19 experts completed all three rounds of which 16(84%) agreed with our final recommendations for the definition of CAL.CONCLUSION A consensus-based recommendation for the definition of CAL was formed using our modified Delphi method that can be widely incorporated in the field. | Claire PM van Helsdingen Audrey CHM Jongen Wouter J de Jonge Nicole D Bouvy Joep PM Derikx | 2020 | World Journal of Gastroenterology2020，26，23： | 3 |
| 6 | Outcomes of the Bowel Cancer Screening Programme (BCSP) in England after the first 1 million tests显示文摘 | Richard F A Logan Julietta Patnick Claire Nickerson Lynn Coleman Matt D Rutter Christian von Wagner | 2012 | Gut2012，，10： | 2 |
| 7 | Experimental endometriosis: the nude mouse as a xerographic host 显示文摘 | Bruner - Tran KL Webster - Clair D Osteen KG | 2001 | Ann NYA cad Sci2001，955，： | 1 |
| 8 | The Impact of Ultraviolet-B Radiation on the Motility of the Freshwater Epipelic Diatom Nitzschia lineariz 显示文摘 | MOROZ A L EHRMAN J M CLAIR T A et d | 1999 | Global Change Biology1999，5，2： | 1 |
| 9 | Acupuncture use in the UnitedStates : findings from the National Health Interview Survey显示文摘 | Burke A Upchurch D Claire D | 2006 | J AltemComplement Med2006，12，7： | 1 |
| 10 | Should patients with challenging anatomy be offered endovascular aneurysm repair显示文摘 | Greenberg RK Clair D Srivastava S | 2003 | J Vasc Surg2003，38，5： | 1 |
| 11 | Infliximab and methotrexate in the treatment of rheumatoid arthritis显示文摘 | Lipsky P E Van der Heijde D M St clair E W | 2000 | N Eng J Med2000，343，： | 1 |
| 12 | The Effects of Microbiotic Soil Crustson Soil Water Loss显示文摘 | George D B Roundy B A Clair L L | 2003 | Arid Land Research and Management2003，17，2： | 1 |
| 13 | Resection of an Intravenous Leiomyoma with intracardiac extension with use of endovascular technique显示文摘 | Clair D Faries P | 2004 | J Vasc Surg2004，40，： | 1 |
| 14 | AC133/CD133/Prominin-1显示文摘 | SHMELKOV S V st CLAIR R LYDEN D | 2005 | Int Biochem Cell Biol2005，37，4： | 1 |
| 15 | Association within a family of a valanced autosomal translocation with major mental illness 显示文摘 | St Clair D Blackwood D Evans H J | 1990 | Lancet1990，336，8706： | 1 |
| 16 | Blocking transition prevents p53 mitochondrial translocation during skin tumor promotion 显示文摘 | LIU J ST CLAIR D K mitochondrial permeability GU X | 2008 | FEBS Letters2008，582，9： | 1 |
| 17 | Association within a family of a balanced autosomal translocation with major mental illness显示文摘 | St Clair D Blackwood D Muir W Carothers A Walker M Spowart G Gosden C Evans H J | | 0，，8706： | 1 |
| 18 | Copy number variation and schizophrenia 显示文摘 | St Clair D | 2009 | Schizophr Bull2009，35，1： | 1 |
| 19 | Gene expression profiling of 3T3-L1 adipocytes exposed to phloretin显示文摘 | Meryl H Claire E Y Christiane M D | 2010 | J Nutr Biochem2010，21，7： | 1 |
| 20 | Enzymatic hydrolysis of cuttlefish (Sepia officinalis) and sardine (Sardina pilchardus) viscera using commercial proteases: effects on lipid distribution and amino acid composition 显示文摘 | Emna S K Justine D Claire D M | 2009 | Journal of Bioscience and Bioengineering2009，107，2： | 1 |
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