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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Comparison of in vivo and in vitro efficacy of ceftizoxime 显示文摘 | Delaney M L Cisneros R L | 1990 | Clin Ther1990，12，： | 2 |
| 3 | Proper differentiation of photoreceptors andamacrine cells depends on a regulatory loop between NeuroDand Six6显示文摘 | Conte I Marco-Ferreres R Beccari L Cisneros E Ruiz JM Tabanera al | 2010 | Development2010，137，14： | 1 |
| 4 | Syn- thesis of novel highly reactive silicone - epoxy monomers for cationic photopolymerizations 显示文摘 | ORTIZ R A CISNEROS M L G GARCIA G A | 2005 | Polymer2005，46，10： | 1 |
| 5 | Passive transfer of poly-(1-6)-beta -glucotriosyl-(1-3)-beta-glucopyranoseglucan protection against lethal infection in an animal model of intra-abdominal sepsis显示文摘 | Cisneros R L F C Gibson A O Tzianabos | 1996 | Infect Immun1996，64，： | 1 |
| 6 | Transcranial Doppler monitoring during head upright tilt table testing in patients with suspected neurocardiogenic syncope 显示文摘 | Albina G Fernandez Cisneros L Laino R | 2004 | Europace2004，6，1： | 1 |
| 7 | Karyolo- gy Geographic Distribution, and Origin of the Genus Dendroctonus Erichson ( Coleoptera : Scolytidae ) 显示文摘 | ZUNIGA G CISNEROS R HAYES J L | 2002 | Annals of the Entomological Society of America2002，95，3： | 1 |
| 8 | Biology and morphology of the cochineal insect,Dactylopius coccus costa(Homopt:dactylopiidae)显示文摘 | Marin L R Cisneros V F | 1977 | Revista Peruanade Entomologia1977，20，1： | 1 |
| 9 | The black scale-insect of cherimoya: Saissetia nigra (Nietner) (Homoptera: Coccidae)显示文摘 | Matin L R Cisneros V F H | 1982 | Revista Peruana de Entomologia1982，22，1： | 1 |
| 10 | Photo degradation of an azo dye of the textile industry 显示文摘 | CISNEROS R L ESPINOZA A G LITTER M I | 2002 | Chemosphere2002，48，4： | 1 |
| 11 | Antiinfective effect of poly -β - ( 1,6) - glucotriosyl -β- ( 1,3 ) - glucopyranose glucan in vivo 显示文摘 | Onderdonk A B Cisneros R L Hinkson P | 1992 | Infect Immun1992，60，： | 1 |
| 12 | Passive transfer of poly - ( 1,6 ) -β- glucotriosyl - ( 1,3 ) -β - glucopyranose glucan protection against lethal infection in an animal model of intraabdominal sepsis 显示文摘 | Cisneros R L Gibson F C Tzianabos A O | 1996 | Infect Immun1996，64，： | 1 |
| 13 | Synthesis of novel highly reactive silicone-epoxy monomers for ca-tionic photo-polymerizations显示文摘 | ORTIZ R A CISNEROS M L G GARCA G A | 2005 | Polymer2005，46，10： | 1 |
| 14 | Influence of rainfall spatial variability on flood prediction 显示文摘 | Arnaud P Bouvier C Cisneros L Dominguez R | 2002 | Journal of Hydrology2002，260，14： | 1 |
| 15 | Antimicrobial efficacy testing of moxifloxacin during the peritonitis and abscess formation stages of intra-abdominal sepsis: A controlled trial in the rat model显示文摘 | Cisneros R L Onderdonk A B | 2002 | Current Therapeutic Research2002，63，12： | 1 |
| 16 | The black scale-insect of cherimoya: Saissetia nigra(Nietner)(Homoptera: Coccidae)显示文摘 | Marin L R Cisneros V F H | 1982 | Revista Peruana de Entomologia1982，22，1： | 1 |
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