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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Comparison of in vivo and in vitro efficacy of ceftizoxime 显示文摘 | Delaney M L Cisneros R L | 1990 | Clin Ther1990，12，： | 2 |
| 3 | Voltammetric determination of trace mercury at a sonogel-carbon electrode modified with poly-3-methylthiophene显示文摘 | Zejli Hanane Sharrock Patrick Hidalgo-Hidalgo de Cisneros J L | 2005 | Talanta2005，68，1： | 1 |
| 4 | Midseason pest status of the Cotton aphid(Homoptera:Aphidiae)in California cotton:is nitrogen a key factor显示文摘 | Cisneros J Godfrey L D | 2001 | Environ Ent2001，30，3： | 1 |
| 5 | Effects of angiogenesis in hibitor TNP-470 on tamoxifen-stimulated MCF-7 breast tumors in nude mice显示文摘 | Takei H l ee ES Cisneros A | 2000 | Cancer Lett2000，155，2： | 1 |
| 6 | Grain Size Effects on the SCC Susceptibility of a Nitrogen Steel in Hot NaCl Solutions 显示文摘 | Opez H F L Cisneros M M Mancha H | 2006 | Corrosion Science2006，，48： | 1 |
| 7 | Risk factors for the development of bronchopulmonary dysplasia: acase-controlstudy显示文摘 | Hernandez-Ronquillo L Tellez-Zenteno JF Weder Cisneros N | 2004 | Arch Med Res2004，35，6： | 1 |
| 8 | Influ- ence of rainfall spatial variability on flood prediction 显示文摘 | ARNAUD P BOUVIER C CISNEROS L | 2002 | Journal of Hydrology2002，260，1234： | 1 |
| 9 | Proper differentiation of photoreceptors andamacrine cells depends on a regulatory loop between NeuroDand Six6显示文摘 | Conte I Marco-Ferreres R Beccari L Cisneros E Ruiz JM Tabanera al | 2010 | Development2010，137，14： | 1 |
| 10 | Syn- thesis of novel highly reactive silicone - epoxy monomers for cationic photopolymerizations 显示文摘 | ORTIZ R A CISNEROS M L G GARCIA G A | 2005 | Polymer2005，46，10： | 1 |
| 11 | Bacterial Swimming and Oxygen Transport Near Contact Lines显示文摘 | Tuval I Cisneros L Dombrowski D | 2005 | Proc Nat Acad Sci USA2005，102，7： | 1 |
| 12 | Phakic intraocular lenses to correct high myopia显示文摘 | José L Menezo Cristina Peris-Mart??nez Angel L Cisneros Rafael Mart??nez-Costa | 2004 | Journal of Cataract & Refractive Surgery2004，，1： | 1 |
| 13 | Contribution of efflux pumps, porins, and β-lactamases to multidrug resistance in clinical isolates of Acinetobacter baumannii 显示文摘 | Rumbo C Gato E Lopez M Ruiz de Alegria C Fernandez-Cuenca F Martinez-Martinez L Vila J Pach6n J Cisneros JM Rodriguez-Bafio J Pascual A Bou G Tomds M Spanish Group of Nosocomial Infections and Mechanisms of Action and Resistance to Antimicrobials ( GEIH-GEMARA ) Spanish Society of Clinical Microbiology and Infectious Diseases ( SEIMC ) Spanish Network for Research in Infectious Diseases (REIPI) | 2013 | Antimicrob Agents Chemother2013，57，11： | 1 |
| 14 | Risk factors for the development of bronchopulmonary dysplasia: a case - control study 显示文摘 | Hernandez - Ronquillo L Tellez - Zenteno JF Weder- Cisneros N | 2004 | Arch Med Res2004，35，6： | 1 |
| 15 | Antioxidantcontent of peach and plum genotypes 显示文摘 | BYRNE D VIZZOTTO M CISNEROS Z L | 2004 | Hortscience2004，39，4： | 1 |
| 16 | Putative dengue virus receptors from mosquito cells显示文摘 | Munoz M L Cisneros A Cruz J | 1998 | FEMS Microbiol Lett1998，168，2： | 1 |
| 17 | Stability of antho- cyanin - based aqueous extracts of Andean purple corn and red -fleshed sweet potato compared to synthetic and natural color- ants 显示文摘 | Cevallos - Casals B A Cisneros - Zevallos L | 2004 | Food Chem2004，86，1： | 1 |
| 18 | Influence of Rainfall Spatial Variability on Flood Prediction 显示文摘 | Arnaud P Bouvier C Cisneros L | 2002 | Journal of Hydrology2002，260，14： | 1 |
| 19 | Thermal inactivation kinetics of peroxidase and lipoxygenase from broccoli,green asparagus and carrots显示文摘 | Morales B E F Chandia V E Cisneros Z L | | 0，，01： | 1 |
| 20 | Influence for rainfall spatial variability on flood prediction显示文摘 | Arnaud P Bouvier C Cisneros L | 2002 | Journal of Hydrology2002，260，14： | 1 |
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