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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Speed, Size, and Edge-rate Information for the Detection of Collision Events 显示文摘 | ANDERSEN G J CISNEROS J ATCHLEY P | 1999 | Journal of Experimental Psychology: Human Perception and Performance1999，25，1： | 1 |
| 3 | Influence of the natural flake graph- ire particle size on the textural characteristic of exfoliated graphite used for heavy oil sorption显示文摘 | Vieira F Cisneros I Rosa N G | 2006 | Carbon2006，44，： | 1 |
| 4 | Association of the CT gene (CA) polymorphism with BMD in osteoporotic mexican women显示文摘 | Maga a JJ G mez R Cisneros B | 2006 | Clin Genet2006，70，： | 1 |
| 5 | Synthesis of novel highly reactive silicone-epoxy mono- mers for cationic photopolymerizations 显示文摘 | ORTIZ R A de LOURDES GUILLIN CISNEROS M GARCIA G A | 2005 | Polymer2005，46，10： | 1 |
| 6 | Matrix metalloproteinasesinhibition attenuates tobacco smoke - induced emphysema in guinea pigs 显示文摘 | Selman M Cisneros - Lira J Gaxiola M Ramirez R Kudlacz E M Mitchell P G Pardo A | 2003 | Chest2003，123，5： | 1 |
| 7 | Vegetation and topographic controls on sediment deposition and storage on gully beds in a degraded mountain area显示文摘 | Molina A Govers G Cisneros F | | 0，，06： | 1 |
| 8 | Parallel iterative reaction path optimization in ab initio quantum mechanical/molecular mechanical modeling of enzyme reactions 显示文摘 | Liu H Y Lu Z Y Cisneros G A | 2004 | J Chem Phys2004，121，： | 1 |
| 9 | A unified model for techniques on video-shot transition detection显示文摘 | BESCOS J CISNEROS G MARTINEZ J M | 2005 | IEEE Transactions on Multimedia2005，7，2： | 1 |
| 10 | Association of interleukin-6 gene polymorphisms with bone mineral density in Mexican women显示文摘 | Magana JJ G o mez R Cisneros B etal | 2008 | J Hum Genet2008，39，6： | 1 |
| 11 | Clinical features and epidemiology of Acinetobacter baumannii colonization and infection in Spanish hospital显示文摘 | Rodriguez-Bano J Cisneros JM Fernandez-Cuenca G | 2004 | Infect Control Hosp Epidemiol2004，25，10： | 1 |
| 12 | Syn- thesis of novel highly reactive silicone - epoxy monomers for cationic photopolymerizations 显示文摘 | ORTIZ R A CISNEROS M L G GARCIA G A | 2005 | Polymer2005，46，10： | 1 |
| 13 | A ki- netic study of the aceeleration effect of substituted benzyl alcohols on the cationic: photopolymerization rate of epoxi- dized natural oils 显示文摘 | ORTIZ R A LOPEZ D P CISNEROS M D G | 2005 | Polymer2005，46，5： | 1 |
| 14 | Speed, Size, and Edge - Rate Information for the Detection of Collision Events 显示文摘 | Anderson G J Cisneros J Atchley P | 1999 | Journal of Experimental Psychology: Human Perception and Performance1999，25，1： | 1 |
| 15 | Fibre Surface Characteristics of Hardwood Refiner Pulps显示文摘 | Cisneros H A Williams G J Hatton J V | 1995 | Journal of Pulp and Paper Science1995，21，5： | 1 |
| 16 | Vegetation and topographic controls on sediment deposition and storage on gully beds in a degraded mountain area显示文摘 | Molina A Govers G Cisneros F | 2009 | Earth Surf Proc Land2009，34，6： | 1 |
| 17 | Contribution of efflux pumps, porins, and β-lactamases to multidrug resistance in clinical isolates of Acinetobacter baumannii 显示文摘 | Rumbo C Gato E Lopez M Ruiz de Alegria C Fernandez-Cuenca F Martinez-Martinez L Vila J Pach6n J Cisneros JM Rodriguez-Bafio J Pascual A Bou G Tomds M Spanish Group of Nosocomial Infections and Mechanisms of Action and Resistance to Antimicrobials ( GEIH-GEMARA ) Spanish Society of Clinical Microbiology and Infectious Diseases ( SEIMC ) Spanish Network for Research in Infectious Diseases (REIPI) | 2013 | Antimicrob Agents Chemother2013，57，11： | 1 |
| 18 | Kawasaki disease: A review with emphasis on cardiovascular complications 显示文摘 | Duarte R Cisneros S Fernandez G | 2010 | Insights Into Ima- ging2010，1，4： | 1 |
| 19 | A unifie model for techniques on video-shot transition detection 显示文摘 | BESCOS J CISNEROS G MARTINEZ J M | 2005 | IEEE Trans Multimed2005，7，2： | 1 |
| 20 | Kawasaki dis- ease: a review with emphasis on cardiovascular complica- tions显示文摘 | Duarte R Cisneros S Fernandez G | 2010 | Insights Imaging2010，1，4： | 1 |
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