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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Risk factors for the acquisition of imipenem resistant Acinetobacter baumannii in Spain: a nationwide study 显示文摘 | Cisneros JM Rodriguez bano J Fernandez cuenca F etal | 2005 | Clin Microlaiol Infect2005，11，11： | 1 |
| 3 | Influence of the natural flake graph- ire particle size on the textural characteristic of exfoliated graphite used for heavy oil sorption显示文摘 | Vieira F Cisneros I Rosa N G | 2006 | Carbon2006，44，： | 1 |
| 4 | Vegetation and topographic controls on sediment deposition and storage on gully beds in a degraded mountain area显示文摘 | Molina A Govers G Cisneros F | | 0，，06： | 1 |
| 5 | Clinical features and epidemiology of Acinetobacter baumanniicolonization and infection in Spanish hospitals显示文摘 | Rodríguez-Bao J Cisneros JM Fernndez-Cuenca F | 2004 | Infect Con-trol Hosp Epidemiol2004，25，： | 1 |
| 6 | Osmoticall induced response in respreacntatives of halophilic:the bacterium Halomounos elongata and the archaeon Haloferax volcanii 显示文摘 | MOICA F J CISNEROS E FERRER C | 1997 | J Bacteriol1997，179，： | 1 |
| 7 | Receptor for advanced glycation end products is upregulated in optic neumpathy of Alzheimer's disease 显示文摘 | WANG M Y ROSS- CISNEROS F N AGGARWAL D | 2009 | Acta Neuro- patho12009，118，3： | 1 |
| 8 | Grain Size Effects on the SCC Susceptibility of a Nitrogen Steel in Hot NaCl Solutions 显示文摘 | Opez H F L Cisneros M M Mancha H | 2006 | Corrosion Science2006，，48： | 1 |
| 9 | clinical features and epidemiology of Acinetobacter baumannii colo nization and infection in Spanish hospitals 显示文摘 | Rodrguez - Bano J Cisneros J M Fernandez - cuenca F | 2004 | Infect control hosp epidemiol2004，25，10： | 1 |
| 10 | Influence of Slaughter Weight on Growth and Carcass Characteristics,Commercial Cutting and Curing Yields,and Meat Quality of Barrows and Gilts from Two Genotypes显示文摘 | Cisneros F Ellis M McKeith F K | 1996 | J Anim Sci1996，74，： | 1 |
| 11 | Electrocardiographic diagnosis of myocardial infarction in the presence of bundle branch block(right and left),ventricular premature beats and Wolff-Parkinson-White syndrome显示文摘 | Sodi-Pallares D Cisneros F Medrano GA | 1963 | Prog Cardiovasc Dis1963，6，2： | 1 |
| 12 | Clinical features and epidemiology of Acinetobacter baumanniicolonization and infection in Spanish hospitals显示文摘 | Rodriguez-BAňo J Cisneros JM Fernández-Cuenca F | 2004 | Infect Con-trol Hosp Epidemiol2004，25，10： | 1 |
| 13 | Bentonites from Cabo de Gata, Almeria, Spain: A mineralog- ical and geochemical overview显示文摘 | Caballero E Jimenez De Cisneros C Huertas F J | 2005 | Clay Minerals2005，40，4： | 1 |
| 14 | Synthesis, characterization,DNA binding study and biological activity against leishmania mexicana of BF4显示文摘 | Maribel N Efren J Cisneros F | 2003 | Inorg Biochem2003，97，4： | 1 |
| 15 | The influence of short-term feeding of amino-acid deficient diets and high dietary leucine levels on the intramuscular fat content of pig muscle显示文摘 | Cisneros F Ellis M Baker D H | 1996 | Journal of Animal Science1996，63，： | 1 |
| 16 | Clinical features and epidemiology of Acinetobacter baumannii colonization and infection in Spanish hospitals 显示文摘 | Rodriguez-Bano J Cisneros JM Fernandez-Cuenca F | 2004 | Infect Control Hosp Epidemiol2004，25，10： | 1 |
| 17 | Prospective evaluation ofb fever of unknown origin in patient infected with the human immunodeficiency virus显示文摘 | Lozano F Towe - Cisneros J Bascunana A | 1996 | Eur J Clin Microbiol Infect Dis1996，15，： | 1 |
| 18 | The influence of time feeding of amino-acid deficient diets on the intramuscular fat content of pork显示文摘 | Cisneros F Ellis M Baker D H | 1996 | Animal Science1996，63，： | 1 |
| 19 | Effect of tempera ture on the tensile properties of an as-cast aluminum alloy A319 显示文摘 | RINCON E LOPEZ H F CISNEROS M M | 2007 | Materials Science and Engineering2007，，： | 1 |
| 20 | Clini- cal features and epidemiology of Acinetobacter baumannii colonization and infection in Spanish hospitals显示文摘 | Rodrfguez-Bano J Cisneros JM Fernandez-Cuenca F | 2004 | Infect Control Hosp Epidemi- ol2004，25，10： | 1 |
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