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| 1 | Current trends in management of hepatitis B virus reactivation in the biologic therapy era显示文摘Hepatitis B virus (HBV) reactivation represents an emerging cause of liver disease in patients undergoing treatment with biologic agents. In particular, the risk ofHBV reactivation is heightened by the use monoclonalantibodies, such as rituximab (anti-CD20) and alemtuzumab (anti-CD52) that cause profound and longlasting immunosuppression. Emerging data indicatethat HBV reactivation could also develop following theuse of other biologic agents, such as tumor necrosis factor (TNF)-α inhibitors. When HBV reactivation is di-agnosed, it is mandatory to suspend biologic treatmentand start antiviral agents immediately. However, preemptive antiviral therapy prior to monoclonal antibodyadministration is crucial in preventing HBV reactivationand its clinical consequences. Several lines of evidencehave shown that risk of HBV reactivation is greatlyreduced by the identifi cation of high-risk patients andthe use of prophylactic antiviral therapy. In this article, we discuss current trends in the management of HBV reactivation in immunosuppressed patients receiving biologic therapy, such as rituximab, alemtuzumab and TNF-α antagonists. | Claudio M Mastroianni Miriam Lichtner Rita Citton Cosmo Del Borgo Angela Rago Helene Martini Giuseppe Cimino Vincenzo Vullo | 2011 | World Journal of Gastroenterology2011，17，34： | 12 |
| 2 | More anxious than depressed:prevalence and correlates in a 15-nation study of anxiety disorders in people with type 2 diabetes mellitus显示文摘Background Anxiety disorder, one of the highly disabling, prevalent and common mental disorders, is known to be more prevalent in persons with type 2 diabetes mellitus (T2DM) than the general population, and the comorbid presence of anxiety disorders is known to have an impact on the diabetes outcome and the quality of life. However, the information on the type of anxiety disorder and its prevalence in persons with T2DM is limited. Aims To assess the prevalence and correlates of anxiety disorder in people with type 2 diabetes in different countries. Methods People aged 18-65 years with diabetes and treated in outpatient settings were recruited in 15 countries and underwent a psychiatric interview with the Mini-International Neuropsychiatric Interview. Demographic and medical record data were collected. Results A total of 3170 people with type 2 diabetes (56.2% women;with mean (SD) duration of diabetes 10.01 (7.0) years) participated. The overall prevalence of anxiety disorders in type 2 diabetic persons was 18%;however, 2.8% of the study population had more than one type of anxiety disorder. The most prevalent anxiety disorders were generalised anxiety disorder (8.1%) and panic disorder (5.1%). Female gender, presence of diabetic complications, longer duration of diabetes and poorer glycaemic control (HbA1c levels) were significantly associated with comorbid anxiety disorder. A higher prevalence of anxiety disorders was observed in Ukraine, Saudi Arabia and Argentina with a lower prevalence in Bangladesh and India. Conclusions Our international study shows that people with type 2 diabetes have a high prevalence of anxiety disorders, especially women, those with diabetic complications, those with a longer duration of diabetes and poorer glycaemic control. Early identification and appropriate timely care of psychiatric problems of people with type 2 diabetes is warranted. | Santosh K Chaturvedi Shayanth Manche Gowda Helal Uddin Ahmed Fahad D Alosaimi Nicola Andreone Alexey Bobrov Viola Bulgari Giuseppe Carra Gianluca Castelnuovo Giovanni de Girolamo Tomasz Gondek Nikola Jovanovic Thummala Kamala Andrzej Ki Nebojsa Lalic Dusica Lecic-Tosevski Fareed Minhas Victoria Mutiso David Ndetei Golam Rabbani Suntibenchakul Somruk Sathyanarayana Srikanta Rizwan Taj Umberto Valentini Olivera Vukovic Wolfgang Wolwer Larry Cimino Arie Nouwen Cathy Lloyd Norman Sartorius | 2019 | General Psychiatry2019，32，4： | 11 |
| 3 | 中国南海软珊瑚Scleronephthya sp.化学成分的研究显示文摘对中国南海的软珊瑚Scleronephthyasp .的化学成分进行研究 ,从有免疫调节活性的乙醚可溶物中分离鉴定了 13个化合物 ,经1HNMR ,13 CNMR ,HMQC ,HMBC ,1H 1HCOSY和MS等光谱分析并结合文献数据 ,确证其结构分别为 :3 β 羟基 2 0 烯孕甾烷乙酸酯 ( 1) ,3 β 羟基 5 ,2 0 二烯孕甾烷乙酸酯 ( 2 ) ,3 酮 2 0 烯孕甾烷 ( 3 ) ,1 ,2 环氧 3 酮 2 0 烯孕甾烷( 4 ) ,1 ,2 0 二烯 3 酮孕甾烷 ( 5 ) ,1 烯 3 酮 2 0S 甲基 2 1 羟基孕甾烷乙酸酯 ( 6) ,1 烯 3 酮 2 0 β 羟基孕甾烷乙酸酯( 7) ,1 烯 3 ,2 2 二酮胆甾烷 ( 8) ,1 ,2 4 二烯 3 酮 2 2 ,2 3 二羟基胆甾烷 ( 9) ,O methylisogrifolin ( 1 0 ) ,( 1R ,3S,4S,7E ,1 1E) 3α,4α 环氧 7,1 1 ,1 5 三烯西松烷 ( 1 1 ) ,玉米黄素 1 2和 6 溴 3 羧酸吲哚 ( 1 3 ) ,其中化合物 4,6和 1 0是首次从自然界分离得到 .首次对化合物 6,7和 1 0的波谱数据进行了报道 ,而且利用 2DNMR对其进行了全归属 .对化合物 1~7可能的生源关系也进行了探讨 .化合物 6和 7对人宫颈癌细胞 (HELA)有抑制活性 ,IC50 分别为 3 .3和6.3mol/L ;化合物7对肝癌细胞 (BE740 2 )和人白血病细胞 (HL 60 )也显示抑制活性 ,IC50 分别为 3 .1和 0 .2 6mol/L ; | 严小红 郭跃伟 朱兴族 MOLLO Ernesto CIMINO Guido | 2004 | 有机化学2004，24，10： | 6 |
| 4 | 中国南海裸鳃目软体动物美丽拟皮片鳃(Dermatobranchus ornatus)及其可能的食源动物柳珊瑚Muricella sp.的化学成分研究显示文摘从中国南海的裸鳃目软体动物美丽拟皮片鳃(Dermatobranchusornatus)中分离得到4个eunicellane型二萜:Ophirin(1),calicophirinB(2),13-去乙酰氧基calicophirinB(3)及3-去乙酰基-13-去乙酰氧基calicophirinB(4);而由同时、同地采集到的柳珊瑚Muricellasp.中则分离得到calicophirinB(2),13-去乙酰氧基calicophirinB(3),astrogorgin(5)及类似物6.这些化合物的结构经波谱学实验并与文献报道的数据相对照得以确定,并首次对Ophirin(1)的NMR数据进行了全归属.Ophirin(1)的单晶X衍射实验不但进一步确证了化合物的结构,而且使这一类化合物的立体结构表述得到修正.本文是对Dermatobranchus属软体动物化学成分研究的首次报道;研究提示,美丽拟皮片鳃能通过选择适当的食物,并将食物中有用的次生代谢产物转移、富集到身体的特定部位,使之成为自身的化学防性物质.美丽拟皮片鳃与Muricella属柳珊瑚中共同出现的类似化合物支持二者间可能存在的捕食与被捕食的生态学关系. | 张文 GAVAGNIN Margherita 郭跃伟 MOLLO Ernesto CIMINO Guido | 2006 | 有机化学2006，26，12： | 6 |
| 5 | 中国南海豆荚软珊瑚(Lobophytum sp.)中倍半萜化学成分的研究显示文摘用硅胶柱层析和凝胶对柱层析对豆荚软珊瑚(Lobophytumsp.)的乙醚提取物进行分离纯化,得到6个倍半萜类似物;根据其化学性质,结合波谱技术(MS,NMR等),它们分别鉴定为:(+)alismol(1),alismoxide(2),entspathulenol(3),(+)10α,4βaromadendranediol(4),4α,10αaromadendranediol(5)及aromadendrane-10α,4βdiol(6)。这些化合物均系首次从该属珊瑚中分离得到。 | 张文 郭跃伟 Mollo Ernesto Cimino Guido | 2005 | 天然产物研究与开发2005，17，6： | 6 |
| 6 | 中国南海曲针绣球海绵Iotrochoto sinustyla化学成分的研究显示文摘从中国南海曲针绣球海绵Iotrochotosinustyla分离得到了 11个有机化合物。经1HNMR、13 CNMR、EIMS等波谱技术分析 ,结合文献对照 ,确定其结构分别为邻苯二甲酸正丁酯 (1) ,3 酮 4 烯豆甾烷 (2 ) ,3,6 二酮 4 烯豆甾烷 (3) ,胆固醇 (4) ,3 酮 4 烯 6 羟基豆甾烷 (5 ) ,鲨肝醇 (6 ) ,3R ,3′R 二羟基 β 胡萝卜素 (7) ,胸酰嘧啶 (8) ,胞嘧啶 (9) ,胸苷 (10 ) ,胞苷 (11) ,本文是对该生物化学成分的首次报道。 | 严小红 郭跃伟 宋国强 Mollo Ernesto Cimino Guido | 2003 | 天然产物研究与开发2003，15，4： | 5 |
| 7 | Anxiety,depression,and quality of life in Parkinson's disease:the implications of multidisciplinary treatment显示文摘Anxiety and depression in Parkinson's disease(PD)reduce well-being of the patients.Emotional alterations influence motor skills and cognitive performance;moreover,they contribute significantly and independently to worsen rehabilitative treatment response.We investigated anxiety,depression,and quality of life in PD patients subjected to multidisciplinary rehabilitative training.The self-controlled study included 100 PD patients(49 males and 51 females with the mean age of 64.66 years)admitted to 60 days hospitalization rehabilitative program,between January 2017 and December 2018.Motor,cognitive,linguistic abilities,and functional independence were evaluated at admission(T0 baseline visit)and 60 days after(T1)the multidisciplinary rehabilitation including motor exercises,speech therapies,and cognitive intervention.The multidisciplinary rehabilitation improved functional status in PD patients and exerted its positive effects on mood,motor abilities,autonomy in the activities of daily life,perception of quality of life,cognitive performance and speech skills.Non-motor symptoms may worsen severe disability and reduce quality of life.They are often poorly recognized and inadequately treated.Nonetheless,multidisciplinary rehabilitative training represents an optimal strategy to improve disease management.The study was approved by Istituito di Ricovero e Cura a Carattere Scientifico(IRCCS)Centro Neurolesi'Bonino-Pulejo'Ethical Committee(approval No.6/2016)in June 2016. | Viviana Lo Buono Rosanna Palmeri Simona De Salvo Matteo Berenati Agata Greco Rosella Ciurleo Chiara Sorbera Vincenzo Cimino Francesco Corallo Placido Bramanti Silvia Marino Giuseppe Di Lorenzo Lilla Bonanno | 2021 | Neural Regeneration Research2021，16，3： | 5 |
| 8 | Circumferential mucosal dissection and esophageal perforation in a patient with eosinophilic esophagitis显示文摘A young man with a previous history of episodes of mild solid food dysphagia was admitted with a total dysphagia. The esophagogastroduodenoscopy (EGDS) showed an extensive disruption of mucosal layer with a cul-de-sac in the lower part of the esophagus. Soon after the procedure, the patient suffered from an acute chest pain and subsequent CT scan demonstrated an intramural circumferential dissection of thoracic esophagus, and a mediastinal emphysema. An emergency right thoracotomy was performed, followed by a total esophagectomy with esophagogastroplasty and jejunostomy. The histopathology confirmed that mucosal and submucosal layers were circumferentially detached from muscular wall and showed an eosinophilic infiltration of the whole organ with necrosis and erosions of mucosal, submucosal and muscular layers. The diagnosis was esophageal perforation in eosinophilic esophagitis. | Gennaro Liguori Maurizio Cortale Fabrizio Cimino Michele Sozzi | 2008 | World Journal of Gastroenterology2008，14，5： | 4 |
| 9 | Hepatitis B vaccine in celiac disease:Yesterday,today and tomorrow显示文摘Some studies showed that in celiac patients the immunological response to vaccination is similar to that one found in general population except for vaccine against hepatitis B virus (HBV).The non-responsiveness to HBV vaccine has also been described in healthy people,nevertheless the number of non-responders has been demonstrated to be higher in celiac disease (CD) patients than in healthy controls.Several hypothesis explaining this higher rate of unresponsiveness to HBV vaccine in CD patients have been described,such as the genetic hypothesis,according with CD patients carrying the disease-specific haplotype HLA-B8,DR3,and DQ2,show a lower response to HBV vaccine both in clinical expressed CD patients and in healthy people carrying the same haplotype.On the other hand,it has been demonstrated that the gluten intake during the vaccination seems to influence the response to the same vaccine.Moreover,it has been demonstrated a possible genetic predisposition to hepatitis B vaccine nonresponsiveness likely due to the presence of specific human leukocyte antigen haplotypes and specific single nucleotide polymorphism in genes of cytokine/cytokinereceptors and toll like receptors,but the pathogenic mechanism responsible for this low responsiveness still remains unclear.The aim of this review is to focus on the possible pathogenic causes of unresponsiveness to HBV vaccine in CD patients and to propose an alternative vaccination schedule in order to improve the responsiveness to HBV vaccine in this at-risk patients. | Giovanna Vitaliti Andrea Domenico Praticò Carla Cimino Giovanna Di Dio Elena Lionetti Mario La Rosa Salvatore Leonardi | 2013 | World Journal of Gastroenterology2013，19，6： | 3 |
| 10 | Surgical treatment of synchronous colorectal liver and lung metastases: the usefulness of thoracophrenolaparotomy for single stage resection显示文摘When suitable, surgery still remains the therapeutic option to be preferred for patients carrier of colorectal liver and lung metastases. Since thoracophrenolaparotomy should be helpful during liver resection for some of these patients, simultaneous removal of right lung metastases can be proposed through this approach. Eleven consecutive patients(median age of 53 years) carrier of colorectal liver and lung metastases, underwent single session surgical resection of both liver and right lung lesions by means of J-shaped thoracophrenolaparotomy. The median number of liver metastases removed was 5(range 2-30) and of lung metastases removed was 2(range 1-3). Lung metastases were located in the upper lobe in 1 patient, in the middle lobe in 2, in the lower lobe in 6, and in the upper and lower lobe in 2. Mortality and major morbidity were nil. Two patients had a minor morbidity: one had wound infection and bile leakage treated conservatively and the other had transient fever. Mean overall survival was 24.4 months. An aggressive surgical approach should be undertaken for colorectal metastases: in case of multifocal liver disease with complex presentations, J-shaped thoracophrenolaparotomy could be considered as safe approach for combined liver and right lung metastasectomies. | Daniele Del Fabbro Marco Alloisio Fabio Procopio Matteo Cimino Matteo Donadon Angela Palmisano Luca Viganò Guido Torzilli | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，2： | 3 |
| 11 | 全外显子组测序发现Merkel细胞癌存在RB基因突变显示文摘Merkel细胞癌是一种罕见的高度侵袭性的皮肤神经内分泌肿瘤,约80%的病例与Merkel细胞多瘤病毒(MCV)感染有关,病毒大T抗原持续表达可能是其发生机制之一。MCV阳性与阴性的Merkel细胞癌在临床表现和形态学上存在重叠,目前分析大多关注MCV阳性Merkel细胞癌的发生机制,对阴性病例则认识不足。本文应用外显子组测序分析5例MCV阳性和3例MCV阴性的Merkel细胞癌样本的基因变异情况。 | Cimino P J Robirds D H Tripp S R 张冲冲 林慧 余英豪 | 2014 | 临床与实验病理学杂志2014，30，11： | 3 |
| 12 | 中国南海粗疣棘柳珊瑚(Acanthogorgia vagae Aurivillius)中萜类化学成分(Ⅱ)显示文摘目的:对采自中国南海的粗疣棘柳珊瑚(AcanthogorgiavagaeAurivillius)的化学成分进行进一步研究,从中寻找有生物活性的次生代谢产物。方法:用硅胶柱层析和凝胶柱层析对粗疣棘柳珊瑚的乙醚提取物进行分离纯化;根据其化学性质,结合现代波谱技术(MS,NMR等),对得到的化合物进行结构鉴定。结果:分离得到2个十碳环倍半萜和3个十四碳环二萜化合物,其结构分别鉴定为:germacrone(1),15-乙酰氧基-fra-nodiene(2),(-)-(1R,2E,4Z,7E,11E)-cembra-2,4,7,11-tetrene(3),thunbergol(4)及其C4-对映异构体(5)。结论:这些化合物均系首次从该属珊瑚中分离得到,并首次对化合物(-)-(1R,2E,4Z,7E,11E)-cembra-2,4,7,11-tetrene(3)氢谱数据进行了全归属。另外,对文献报道的germacrone(1)的部分氢谱数据进行了重新归属。 | 张文 郭跃伟 Ernesto Mollo Guido Cimino | 2005 | 中国天然药物2005，3，5： | 2 |
| 13 | 中国南海粗疣棘柳珊瑚中倍半萜成分研究显示文摘目的:对采自中国南海的粗疣棘柳珊瑚(Acanthogorgia vagae)的化学成分进行研究,从中寻找有生物活性的次生代谢产物。方法:用硅胶柱层析对粗疣棘柳珊瑚的乙醚提取物进行分离纯化;根据其化学性质,结合现代波谱技术(MS,NMR等),对得到的化合物进行结构鉴定。结果:分离得到4个呋喃倍半萜化合物,其结构分别鉴定为lindenene(1),linelestrene(2),bebryazulene(3)及franodiene(4)。结论:本文系首次对该珊瑚化学成分进行研究;4个倍半萜成分亦均为首次从该生物中分离得到。其中,lindenene(1)的碳谱数据为首次报道,并首次对化合物lindenene(1)及franodiene(4)氢谱数据进行了全归属。另外,对文献报道的bebryazulene(3)及franodiene(4)的碳谱数据进行了重新归属。 | 张文 郭跃伟 Ernesto Mollo Guido Cimino | 2003 | 中国天然药物2003，1，1： | 2 |
| 14 | Total discrimination of peritoneal malignant ascitos from cirrhosis-and hepatocarcionoma-associated ascitos by assays of ascitic cholesterd and lactate dehydrogenase显示文摘 | Oriani G Cimino L | 1994 | Ctin Chem1994，40，3： | 1 |
| 15 | Chronic hemodialysis using venipuncture and a surgically created arteriovenous fistula显示文摘 | BRESCIA M J CIMINO J E APPLE K | 1966 | New J Med1966，275，： | 1 |
| 16 | Toxic effect of nic-kel in an in vitro model of human oral epithelium显示文摘 | Trombetta D Mondello MR Cimino F | 2005 | Toxicol Lett2005，159，3： | 1 |
| 17 | Biological and therapeutic aspects of infant leukemia 显示文摘 | Biondi A Cimino G Pieters R | 2000 | Blood2000，96，： | 1 |
| 18 | Thermodynamic modeling forprediction of asphaltene deposition inlive oils显示文摘 | Cimino R Correra P A Camiani C | 1995 | SPE 289931995，，： | 1 |
| 19 | Simvastatin reduces caspase-3 activation and inflammatory markers induced by hypoxia-ischemia in the newborn rat 显示文摘 | Carloni S Mazzoni E Cimino M | 2006 | Neurobiol Dis2006，21，： | 1 |
| 20 | Robotic Single-site Hysterectomy in Low Risk Endometrial Cancer: A Pilot Study显示文摘 | Enrico Vizza Giacomo Corrado Emanuela Mancini Ermelinda Baiocco Lodovico Patrizi Luana Fabrizi Luca Colantonio Monica Cimino Stefano Sindico Ester Forastiere | 2013 | Annals of Surgical Oncology2013，，8： | 1 |
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