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334篇 您的检索式:作者名="CIECHANOVER"
    题名 作者 年代 出处 被引量
1The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death显示文摘26S proteasome 是一大, ~ 2.5 MDa,用作 ubiquitin 系统的降级的手臂的多催化的 ATP 依赖的朊酶建筑群,它是主要小径为调整了 cytosolic 的降级,原子并且在所有真核细胞的有机体的膜蛋白质。Ido Livneh Victoria Cohen-Kaplan Chen Cohen-Rosenzweig Noa Avni Aaron Ciechanover 2016Cell Research2016,26,8:11
2泛素介导的蛋白质降解系统——从基础研究到临床应用显示文摘20世纪60~80年代,大多数生物科研人员都致力于核酸和遗传信息传递的研究。蛋白质降解被认为是非特异的过程,因此没有人感兴趣。泛素修饰的发现使蛋白质降解领域发生革命性的变化,人们逐渐认识到蛋白质降解是一个特异的受严格调控的过程。细胞内蛋白质降解事件的发生会调节许多生命过程,如细胞增殖、分化、衰老和死亡。细胞内蛋白质降解调控异常也会引发多种疾病,包括癌症和神经退行性疾病。人们对细胞内蛋白质降解的研究已经取得一定成果,但是还有很多问题没有解决,全面解读该过程还需要更多的努力和探索。Aaron Ciechanover 葛亮 2010生命科学2010,22,3:6
3Modes of regulation of ubiquitin-mediated protein degradation显示文摘Kornitzer D Ciechanover A 2000J Cell Physiol2000,182,1:1
4Ubiqnitin-mediated proteolysis: biological regulation via destruction显示文摘Ciechanover A Orian A Schwartz A L 2000Bioessays2000,22,:1
5The ubiquitin system 显示文摘Hershko A Ciechanover A 1998Annu Rev Biochem1998,67,:1
6ATP-dependentconjugation of reticulocyte proteins with the polypeptide re- quired for protein degradation显示文摘Ciechanover A Heller H Elias S 1980Proc Natl Acad Sci USA1980,77,3:1
7The ubiquitin system 显示文摘HERSHKO A CIECHANOVER A 1998Annu Rev Biochem1998,67,:1
8A heat-stable polypep tide component of an ATP-dependent proteolytic system from reticulocytes 1978显示文摘Ciechanover A Hod Y Hershko A 2012Biochem Biophys Res Commun2012,425,56:1
9Ubiquitin as a Central Cellular Regulator显示文摘Finley D Ciechanover A Varshavsky A 2004Cell2004,116,:1
10The ubiquitin-proteasome pro- teolytic pathway: destruction for the sake of construction 显示文摘Glickman MH Ciechanover A 2002 2002Physiological Reviews2002,82,2:1
11The ubiquitin system 显示文摘Hershko A Ciechanover A 1998Annu Rev Biochem1998,67,:1
12The ubiquitin system显示文摘Hershko A Ciechanover A Varshavsky A 2000Nature Med2000,6,10:1
13The Uiquitin-Proteasome Proteolytic Pathway:Destruction for the Sake of Construction显示文摘 CIECHANOVER A 2002Physiol Rev(S0031-9333)2002,82,2:1
14The ubiquitin-proteasome pathway:on protein death and cell life显示文摘Ciechanover A 1998Embo J1998,17,24:1
15Ubiquitin-mediatedproteolysis:biological regulation via destruction显示文摘Ciechanover A Orian A Schwartz A L 2000Bioessays2000,22,5:1
16Resolution of the Atp dependent proteolytic system from reticulocytes: a compo- nent that interacts with ATP显示文摘Hershko A Ciechanover A Rose IA 1979Proc Natl Acad Sci USA1979,76,7:1
17The ubiquitin proteolytic system: from a vague idea, through basic mechanisms, and onto human diseases and drug targeting显示文摘Ciechanover A 2006Neurology2006,66,21:1
18The ubiquitin system 显示文摘Hershko A Ciechanover A 1998Annual Review of Biochemistry1998,67,:1
19Ubiquitin as a central cellular regulator显示文摘Finley D Ciechanover A Varshavsky A 2004Cell2004,116,:1
20Ubiquitin-mediated proteolysis: biological regulation via destruction 显示文摘Ciechanover A Orian A Schwartz AL 2000Bioessays2000,22,5:1
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