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2篇 您的检索式:作者名="CHRISBLEACKLEY"
    题名 作者 年代 出处 被引量
1Granzyme B: a natural born killer显示文摘Sarah J.Lord Ray V.Rajotte Gregory S.Korbutt R. ChrisBleackley 2003Immunological Reviews2003,,1:1
2Cytotoxic T cell-induced apoptosis显示文摘Cytotoxic T lymphocytes and natural killer cells protect us against a variety of pathogens, and are involved in autoimmune diseases and transplant rejection. Granzyme B plays a major role in the mechanism used by these cytolytic effectors to destroy the target cells. This proteinase is produced by the effectors and stored within cytoplasmic granules. Upon interaction with the pathogenic cell the granzyme is transferred from the CTL to the target via directed exocytosis and subsequent receptor mediated endocytosis. It is interesting that cells that are deficient in expression of the receptor for granzyme are also resistant to CTL-CHRISBLEACKLEY 2002Cell Research2002,12,3:0
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