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| 1 | The improved element-free Galerkin method for three-dimensional transient heat conduction problems显示文摘With the improved moving least-squares (IMLS) approximation, an orthogonal function system with a weight function is used as the basis function. The combination of the element-free Galerkin (EFG) method and the IMLS approximation leads to the development of the improved element-free Galerkin (IEFG) method. In this paper, the IEFG method is applied to study the partial differential equations that control the heat flow in three-dimensional space. With the IEFG technique, the Galerkin weak form is employed to develop the discretized system equations, and the penalty method is applied to impose the essential boundary conditions. The traditional difference method for two-point boundary value problems is selected for the time discretization. As the transient heat conduction equations and the boundary and initial conditions are time dependent, the scaling parameter, number of nodes and time step length are considered in a convergence study. | ZHANG Zan WANG JianFei CHENG YuMin LIEW Kim Meow | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，8： | 18 |
| 2 | Mitochondrial calcium uniporter protein MCU is involved in oxidative stress-induced cell death显示文摘Mitochondrial 钙 uniporter (MCU ) 是在在真核细胞的房间的 mitochondrial 的保存 Ca 2+ transporter。然而,在氧化导致压力的房间死亡的 MCU 蛋白质的角色仍然保持不清楚。这里,我们证明宫外地表示的 MCU 是在局部性的 mitochondrial HeLa 和主要小脑的小粒神经原(CGN ) 。内长的 MCU 减少 mitochondrial Ca 2+ 举起追随者组织安刺激击倒并且稀释氧化应力在 HeLa 房间和 CGN 导致的房间死亡。我们也发现 MCU 与 VDAC1 交往并且调停在 CGN 的 VDAC1 导致 overexpression 的房间死亡。这发现证明那 MCU-VDAC1 建筑群调整 mitochondrial Ca 2+ 举起和氧化导致压力的 apoptosis,它可能表示为氧化应力的治疗学的目标联系了疾病。 | Yajin Liao Yumin Hao Hong Chen Qing He Zengqiang Yuan Jinbo Cheng | 2015 | Protein & Cell2015，6，6： | 12 |
| 3 | An experiment-library least-squares method on on-line coal element contents analysis显示文摘A new experiment-library least-squares(experiment-LLs) method used in the neutron inelastic-scattering and thermal-capture analysis(NITA) technique for on-line coal analysis was developed,which has significantly decreased the non-linear radiation effects.In this method,sixty samples with preset elemental contents were made,from whose experimental spectra twenty single-element spectrum libraries corresponding to twenty kinds of coal were built using the least-squares method.The spectrum of the unknown sample was analyzed based on these twenty libraries to estimate its element contents.With the initial estimated result,the procedure of developing library and analysis was iterated to build a new library with the closest element contents to the unknown sample.Hence the experiment-LLs method can reduce non-linear radiation effects.The experiment-LLs method was performed on an improved coal analysis system which was equipped with a long-life 14 MeV pulsed-neutron generator,a bulk BGO detector with a temperature controller,a moisture meter and coal-smoothing device.The precisions of this system for ash content,water content,volatile content and calorific value have reached 1.0wt%,0.5wt%,1.0wt%,350 kJ/kg,respectively. | WANG HuiDong LU JingBin LU YuPing YANG Dong MA KeYan YANG Kang LIU YuMin CHENG DaoWen | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，11： | 6 |
| 4 | An interpolating boundary element-free method (IBEFM) for elasticity problems显示文摘The paper begins by discussing the interpolating moving least-squares (IMLS) method. Then the formulae of the IMLS method obtained by Lancaster are revised. On the basis of the boundary element-free method (BEFM), combining the boundary integral equation method with the IMLS method improved in this paper, the interpolating boundary element-free method (IBEFM) for two-dimensional elasticity problems is presented, and the corresponding formulae of the IBEFM for two-dimensional elasticity problems are obtained. In the IMLS method in this paper, the shape function satisfies the property of Kronecker δ function, and then in the IBEFM the boundary conditions can be applied directly and easily. The IBEFM is a direct meshless boundary integral equation method in which the basic unknown quantity is the real solution to the nodal variables. Thus it gives a greater computational precision. Numerical examples are presented to demonstrate the method. | REN HongPing 1 , CHENG YuMin 2 & ZHANG Wu 1 1 School of Computer Engineering and Science, Shanghai University, Shanghai 200072, China 2 Shanghai Institute of Applied Mathematics and Mechanics, Shanghai University, Shanghai 200072, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，4： | 5 |
| 5 | The dimension splitting element-free Galerkin method for 3D transient heat conduction problems显示文摘By transforming a 3D problem into some related 2D problems, the dimension splitting element-free Galerkin(DSEFG) method is proposed to solve 3D transient heat conduction problems. The improved element-free Galerkin(IEFG) method is used for 2D transient heat conduction problems, and the finite difference method is applied in the splitting direction. The discretized system equation is obtained based on the Galerkin weak form of 2D problem; the essential boundary conditions are imposed with the penalty method; and the finite difference method is employed in the time domain. Four exemplary problems are chosen to verify the efficiency of the DSEFG method. The numerical solutions show that the efficiency and precision of the DSEFG method are greater than ones of the IEFG method for 3D problems. | ZhiJuan Meng Heng Cheng LiDong Ma YuMin Cheng | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，4： | 5 |
| 6 | Loss of Wip1 aggravates brain injury after ischaemia/reperfusion by overactivating microglia显示文摘Background and purpose The inflammatory response mediated by microglia/macrophages is closely related to cerebral ischaemia/reperfusion injury.Wild-type p53-induced protein phosphatase 1(Wip1),a serine/threonine phosphatase,is expressed in various tissues.A growing number of reports have suggested that Wip1 is a negative regulator of inflammation in peripheral tissue;however,its role in the central nervous system(CNS)remains unclear.This study aimed to clarify whether Wip1 can inhibit CNS inflammation by regulating microglia/macrophage functions after ischaemic injury.Methods A model of middle cerebral artery occlusion and reperfusion was established in mice.CNS inflammation was simulated by lipopolysaccharide treatment of primary microglia.Laser speckle imaging was used to monitor regional cerebral blood flow.Behavioural outcomes were assessed with a TreadScan gait analysis system.TTC staining was used to evaluate the infarct volume,and western blotting and immunofluorescence staining were applied to detect the phenotypical transformation of microglia.ELISA was performed to detect the levels of inflammatory factors.Results Wip1 expression was increased after ischaemia/reperfusion.Wip1-knockout(KO)mice displayed more severe brain injury than wild-type mice,as indicated by aggravated motor dysfunction,greater brain infarct volumes and higher expression of inflammatory cytokines(interleukin-6 and tumour necrosis factor alpha)in the brain.We also found that Wip1 depletion increased microglial/macrophage activation in both in vitro and in vivo models,which all showed activation of microglia/macrophages.Lentivirus-Ppm1d reversed the injury induced by Wip1-KO.Conclusions Our results suggest that Wip1 may inhibit neuroinflammation by inhibiting microglial/macrophage activation after brain ischaemia/reperfusion injury. | Feng Yan Xiang Cheng Ming Zhao Shenghui Gong Ying Han Liping Ding Di Wu Yumin Luo Wei Zuo Lingling Zhu Ming Fan Xunming Ji | 2021 | Stroke & Vascular Neurology2021，6，3： | 4 |
| 7 | A Boundary Element-Free Method (BEFM) for three-dimensional elasticity problems 显示文摘 | KITIPORNCHAI S LIEW K M CHENG Yumin | 2005 | Comput Mech2005，36，1： | 1 |
| 8 | Boundary Element-Free Method (BEFM) for two-dimensional elastodynamic analysis using Laplace transform显示文摘 | LIEW K M CHENG Yumin KITIPORNCHAI S | 2005 | Int J for Numerical Methods in Eng2005，64，12： | 1 |
| 9 | Optimal channels of the Garvey-Kelson mass relations in extrapolation显示文摘Garvey-Kelson mass relations connect nuclear masses of neighboring nuclei within high accuracy, and provide us with convenient tools in predicting unknown masses by extrapolations from existent experimental data. In this paper we investigate optimal'channels' of the Garvey-Kelson relations in extrapolation to the unknown regions, and tabulate our predicted masses by using these optimized channels of the Garvey-Kelson relations. | Man Bao Zeng He YiYuan Cheng YuMin Zhao Akito Arima | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，2： | 1 |
| 10 | Boundary Element-Free Method (BEFM) and its application to two-dimensional elasticity problems显示文摘 | LIEW K M CHENG Yumin KITIPORNCHAI S | 2006 | Int J for Numerical Methods in Eng2006，65，8： | 1 |
| 11 | A Boundary Element-Free Method (BEFM) for two-dimensional potential problems 显示文摘 | PENG Miaojuan CHENG Yumin | 2009 | Eng Analysis with Boundary Elements2009，33，1： | 1 |
| 12 | Coupling of improved element-free Galerkin and boundary element methods for the 2D elasticity problems显示文摘 | ZHANG Zan LIEW K M CHENG Yumin | 2008 | Eng Analysis with Boundary Elements2008，32，2： | 1 |
| 13 | Analyzing 2D fracture problems with the improved element-free Galerkin method 显示文摘 | ZHANG Zan LIEW K M CHENG Yumin | 2008 | Eng Analysis with Boundary Elements2008，32，： | 1 |
| 14 | The interpolating element-free Galerkin method for elastic large deformation problems显示文摘This paper presents an interpolating element-free Galerkin(IEFG) method for solving the two-dimensional(2D) elastic large deformation problems. By using the improved interpolating moving least-squares method to form shape function, and using the Galerkin weak form of 2D elastic large deformation problems to obtain the discrete equations, we obtain the formulae of the IEFG method for 2D elastic large deformation problems. As the displacement boundary conditions can be applied directly, the IEFG method can acquire higher computational efficiency and accuracy than the traditional element-free Galerkin(EFG)method, which is based on the moving least-squares approximation and can not apply the displacement boundary conditions directly. To analyze the influences of node distribution, scale parameter of influence domain and the loading step on the numerical solutions of the IEFG method, three numerical examples are proposed. The IEFG method has almost the same high accuracy as the EFG method, and for some 2D elastic large deformation problems the IEFG method even has higher computational accuracy. | WU Qiang PENG PiaoPiao CHENG YuMin | 2021 | Science China(Technological Sciences)2021，64，2： | 1 |
| 15 | Fibroblast exosomal TFAP2C induced by chitosan oligosaccharides promotes peripheral axon regeneration via the miR-132-5p/CAMKK1 axis显示文摘Chitosan and its degradation product,oligosaccharides,have been shown to facilitate peripheral nerve regeneration.However,the underlying mechanisms are not well understood.In this study,we analyzed the protein expression profiles in sciatic nerves after injury using proteomics.A group of proteins related to exosome packaging and transport is up-regulated by chitosan oligosaccharides(COS),implying that exosomes are involved in COS-induced peripheral nerve regeneration.In fact,exosomes derived from fibroblasts(f-EXOs)treated with COS significantly promoted axon extension and regeneration.Exosomal protein identification and functional studies,revealed that TFAP2C is a key factor in neurite outgrowth induced by COS-f-EXOs.Furthermore,we showed that TFAP2C targets the pri-miRNA-132 gene and represses miR-132-5p expression in dorsal root ganglion neurons.Camkk1 is a downstream substrate of miR-132-5p that positively affects axon extension.In rats,miR-132-5p antagomir stimulates CAMKK1 expression and improves axon regeneration and functional recovery in sciatic nerves after injury.Our data reveal the mechanism for COS in axon regeneration,that is COS induce fibroblasts to produce TFAP2C-enriched EXOs,which are then transferred into axons to promote axon regeneration via miR-132-5p/CAMKK1.Moreover,these results show a new facet of fibroblasts in axon regeneration in peripheral nerves. | Yahong Zhao Jina Liu Sha Liu Panpan Yang Yunyun Liang Jinyu Ma Susu Mao Cheng Sun Yumin Yang | 2023 | Bioactive Materials2023，，8： | 1 |
| 16 | Method of Finite Nonlinear Structural The coupling Boundary and Element for Problem of Engineering 显示文摘 | Cheng Yumin Peng Miaojuan | 1998 | Theory and Applications of Boundary Element Methods:International Academic publishers1998，，： | 1 |
| 17 | MED4 gene positively affects preadipocyte differentiation in Chinese red steppe cattle显示文摘Background:The regulatory genes related to lipid metabolism affect the intramuscular fat(IMF)content and improve meat quality traits.Mediator Complex Subunit 4(MED4),a vitamin D receptor protein,affects vitamin D,livestock growth,carcass traits,and triglyceride deposition.However,the physiological function of the MED4 gene on bovine adipocyte differentiation remains unknown.Methods:This study explored the function of the MED4 gene in preadipocyte differentiation in Chinese Red Steppe cattle.The overexpression plasmid and the interference sequences of the MED4 gene were constructed to detect the effects of the MED4 gene on adipogenesis and biomakers using quantitative polymerase chain reaction and western blotting.Results:The MED4 gene had significantly high expression during preadipocyte differentiation(p<0.05).Overexpression of the MED4 gene increased the expression of the PPARγgene,a preadipocyte differentiation biomarker,improved cellular lipid droplets and triglycerides accumulation,and positively accelerated adipocyte maturation(p<0.05).Interference of the MED4 gene can negatively regulate preadipocyte differentiation.Conclusion:This study showed that the MED4 gene may affect the preadipocyte differentiation and adipogenesis in Chinese Red Steppe cattle by regulating the PPARγgene. | MINGHONG WEI CHENG XIAO JIAN WU LIHONG QIN HONGLIANG LIU YANG CAO YUMIN ZHAO | 2023 | BIOCELL2023，47，9： | 0 |
| 18 | A Fast Element-Free Galerkin Method for 3D Elasticity Problems显示文摘In this paper,a fast element-free Galerkin(FEFG)method for three-dimensional(3D)elasticity problems is established.The FEFG method is a combination of the improved element-free Galerkin(IEFG)method and the dimension splitting method(DSM).By using the DSM,a 3D problem is converted to a series of 2D ones,and the IEFG method with a weighted orthogonal function as the basis function and the cubic spline function as the weight function is applied to simulate these 2D problems.The essential boundary conditions are treated by the penalty method.The splitting direction uses the finite difference method(FDM),which can combine these 2D problems into a discrete system.Finally,the system equation of the 3D elasticity problem is obtained.Some specific numerical problems are provided to illustrate the effectiveness and advantages of the FEFG method for 3D elasticity by comparing the results of the FEFG method with those of the IEFG method.The convergence and relative error norm of the FEFG method for elasticity are also studied. | Zhijuan Meng Yanan Fang Yumin Cheng | 2022 | Computer Modeling in Engineering & Sciences2022，，7： | 0 |
| 19 | Effects of Doping Trace Sm^(3+) and Gd^(3+) on Luminescent Character of Y_2O_2S∶Eu^(3+)显示文摘After trace Sm3+ ions and Gd3+ ions doping, the emission intensity of red phosphors Y2O2S∶Eu3+ was enhanced and the voltage character (relation between emission intensity and excitation voltage) was improved while the other properties of physics and chemistry were not changed. The origins of enhancement and improvement are discussed. Probably the distortion and the defect of crystals are decreased by the substitution of Gd3+ for Y3+ instead of Eu3+ for Y3+, and thus the Eu3+ crystal field is improved, and radiationless process and energy loss resulted from crystal defect are weakened, which leads to increased luminescence intensity and voltage character improvement. The overlapping fluorescent spectra of Y2O2S∶Sm3+ emission and Y2O2S∶Eu3+ excitation as well as Eu3+ excitation spectra containing Sm3+ excitation transitions spectra lead to the possibility of resonance energy transfer from Sm3+ ions to Eu3+ ions, and the sensitization of Sm3+ ions to Eu3+ ions is achieved effectively. | Yuan Jianhui Yuan Honghui Zhang Zhenhua Cheng Yumin Wang Xiaojun | 2005 | Journal of Rare Earths2005，23，4： | 0 |
| 20 | New Thinking for Asian Economic Community显示文摘 | Mingxuan Cheng Weidong Huo Yumin Zhang | 2005 | China-USA Business Review2005，4，10： | 0 |
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