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您的检索式：作者名="CHEN Tangjun"
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| 1 | Autologous fibroblasts induce fibrosis of the nucleus pulposus to maintain the stability of degenerative intervertebral discs显示文摘Lumbar degenerative disc diseases cause low back pain(LBP). The maintenance of the height and stability of the intervertebral disc(IVD) space is an effective treatment for LBP. The following study evaluated the effects of fibroblast injection on intervertebral disc degeneration(IDD) in a preclinical setting. Compared with the IDD group, the fibroblast treatment group demonstrated effective maintenance of IVD height, reduced endplate degeneration, and improved nuclear magnetic resonance signals and overall histological structure. In doing so, fibrotic IVDs maintained the stability and biomechanics of the vertebra. This finding is in agreement with clinical findings that human nucleus pulposus(NP) fibrosis is essential for the maintenance of IVD height and mechanical properties in patients following percutaneous endoscopic lumbar discectomy(PELD). Mechanistically, we demonstrated that injected fibroblasts not only proliferated but also induced NP cells to adopt a fibrotic phenotype via the secretion of TGF-β.Finally, to better mimic human conditions, the efficacy of autologous fibroblast injection in the treatment of IDD was further examined in a nonhuman primate cynomolgus monkey model due to their capacity for upright posture. We showed that the injection of fibroblasts could maintain the IVD height and rescue IVD signals in cynomolgus monkeys. Taken together, the results of our study reveal that autologous fibroblast injection can enhance the natural process of fibrosis during acute and subacute stages of stress-induced IDD. Fibrotic IVDs can maintain the stability, biological activity, and mechanical properties of the intervertebral space, thus providing a new direction for the treatment of intervertebral space-derived lumbar degenerative diseases. | Chen Chen Tangjun Zhou Xiaojiang Sun Chen Han Kai Zhang Changqing Zhao Xunlin Li Haijun Tian Xiao Yang Yifan Zhou Zhiqian Chen An Qin Jie Zhao | 2020 | Bone Research2020，8，1： | 3 |
| 2 | Variable scheduling interval task scheduling for phased array radar显示文摘A scheduling algorithm is presented aiming at the task scheduling problem in the phased array radar. Rather than assuming the scheduling interval(SI) time, which is the update interval of the radar invoking the scheduling algorithm, to be a fixed value,it is modeled as a fuzzy set to improve the scheduling flexibility.The scheduling algorithm exploits the fuzzy set model in order to intelligently adjust the SI time. The idle time in other SIs is provided for SIs which will be overload. Thereby more request tasks can be accommodated. The simulation results show that the proposed algorithm improves the successful scheduling ratio by 16%,the threat ratio of execution by 16% and the time utilization ratio by 15% compared with the highest task mode priority first(HPF)algorithm. | ZHANG Haowei XIE Junwei ZHANG Zhaojian SHAO Lei CHEN Tangjun | 2018 | Journal of Systems Engineering and Electronics2018，29，5： | 3 |
| 3 | Simple and efficient CuI/PEG-400 system for amination of aryl halides with aqueous ammonia 显示文摘 | CHEN Junmin YUAN Tangjun HAO Wenyan | 2011 | Tetrahedron Lett2011，52，29： | 1 |
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