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| 1 | Duodenal gangliocytic paraganglioma with lymph node metastases: a case report and comparative review of 31 cases显示文摘Gangliocytic paraganglioma(GP) is a rare tumor of uncertain origin most often located in the second portion of the duodenum. It is composed of three cellular components: Epithelioid endocrine cells, spindlelike/sustentacular cells, and ganglion-like cells. While this tumor most often behaves in a benign manner, cases with metastasis are reported. We describe the case of a 62-year-old male with a periampullary GP with metastases to two regional lymph nodes who was successfully treated with pancreaticoduodenectomy. Using Pub Med, EMBASE, EBSCOhost MEDLINE and CINAHL, and Google Scholar, we searched the literature for cases of GP with regional lymph node metastasis and evaluated the varying presentations, diagnostic workup, and disease management of identified cases. Thirty-one cases of GP with metastasis were compiled(30 with at least lymph node metastases and one with only distant metastasis to bone), with age at diagnosis ranging from 16 to 74 years. Ratio of males to females was 19:12. The most common presenting symptoms were abdominal pain(55%) and gastrointestinal bleeding or sequelae(42%). Twenty-five patients underwent pancreaticoduodenectomy. Five patients were treated with local resection alone. One patient died secondary to metastatic disease, and one died secondary to perioperative decompensation. The remainder did well, with no evidence of disease at follow-up from the most recent procedure(except two in which residual disease was deliberately left behind). Of the 26 cases with sufficient histological description, 16 described a primary tumor that infiltrated deep to the submucosa, and 3 described lymphovascular invasion. Of the specific immunohistochemistry staining patterns studied, synaptophysin(SYN) stained all epithelioid endocrine cells(18/18). Neuron specific enolase(NSE) and SYN stained most ganglion-like cells(7/8 and 13/18 respectively), and S-100 stained all spindle-like/sustentacular cells(21/21). Our literature review of published cases of GP with lymph node metastasis underscores the excellent prognosis of GP regardless of specific treatment modality. We question the necessity of aggressive surgical intervention in select patients, and argue that local resection of the mass and metastasis may be adequate. We also emphasize the importance of pre-surgical assessment with imaging studies, as well as post-surgical follow-up surveillance for disease recurrence. | Sahara J Cathcart Aaron R Sasson Jessica A Kozel Jennifer M Oliveto Quan P Ly | 2017 | World Journal of Clinical Cases2017，5，6： | 9 |
| 2 | Cyclooxygenasez-linked attenuation of hypoxia-induced pulmonary hypertension and intravascular thrombosis 显示文摘 | Cathcart M C Tamosiuniene R Chen G | 2008 | Pharmacol Exp Ther2008，326，1： | 1 |
| 3 | Regulation of superoxide anion production by NADPH oxides in monocytes/macrophages: Contribu- tions to atherosclerosis显示文摘 | Cathcart M K | 2004 | Artefioscler Thromb Vasc Biol2004，24，1： | 1 |
| 4 | Incidence of primary and recurrent acute urinary retention between 1998 and 2003 in England显示文摘 | Cathcart P van der Meulen J Armitage J Emberton M | 2006 | J Urol2006，176，1： | 1 |
| 5 | Regulation of superoxide anion production by NADPH oxidase in monocytes/macrophages:contributions to atherosclerosis 显示文摘 | Cathcart M K | 2004 | Arterioscler Thromb Vasc Biol2004，24，1： | 1 |
| 6 | Regulation of superoxide anion production by NAD-PH oxidase in monocytes/macrophages contributions to atheroscl-erosis显示文摘 | | 2004 | Arterioscler Thromb Vasc Biol2004，24，1： | 1 |
| 7 | Regulation of superoxide anion production by NADPH oxidase in monocvtes/macrophages contributions to atherosclerosis 显示文摘 | Cathcart M K | 2004 | Arterioscler Thromb Vasc Biol2004，24，1： | 1 |
| 8 | Litter ammonia generation: moisture content and organic versus inorganic bedding materials显示文摘 | Miles D M Rowe D E Cathcart T C | 2011 | Poultry Science2011，90，： | 1 |
| 9 | Regulation of superoxide anion production by NADPH oxides in monocytes/macrophages; Contributions to atherosclerosis显示文摘 | Cathcart M K | 2004 | ArteriosclerThromb Vasc Biol2004，24，1： | 1 |
| 10 | Regulation of superoxide anion production by NADPH oxidase in monocytes/macrophages:contributions to atherosclerosis显示文摘 | CATHCART M K | 2004 | Arterioscler Thromb Vasc Biol2004，24，1： | 1 |
| 11 | Effect of 2 weeks of sprint interval training on health-related outcomes in sedentary overweight obese men显示文摘 | WHYTE L J GILL J M CATHCART A J | 2010 | Metabolism2010，59，10： | 1 |
| 12 | Examinationof thromboxane synthase as a prognostic factor and therapeutic targetin non - small cell lung cancer显示文摘 | CATHCART M C GATELY K CUMMINS R | 2011 | Mol Cancer2011，10，： | 1 |
| 13 | A description of radical nephrectomy practice and outcomes in England:1995-2002显示文摘 | Nuttall M Cathcart P van der Meulen J | 2005 | BJU Int2005，96，1： | 1 |
| 14 | The influence of thymic humoral factor on systemic lupus erythematosus lymphocyte function显示文摘 | WYSENBEEK A J TRAININ N CATHCART M | 1985 | Int J Immunoph1985，7，： | 1 |
| 15 | High litter moisture content suppresses litter ammonia volatilization 显示文摘 | MILES D M ROWE D E CATHCART T C | 2011 | Poultry Science2011，90，7： | 1 |
| 16 | Monocytes and neutrophils oxidize low density lipoprotein making it cytotox- ic 显示文摘 | Cathcart M K Morel D W Chisolm G M | 1985 | Journal of Leukocyte Biology1985，38，2： | 1 |
| 17 | Trends in paediatric circumcision and its complications in England between 1997 and 2003显示文摘 | Cathcart P Nuttall M van der Meulen J | 2006 | Br J Surg2006，93，7： | 1 |
| 18 | Target and Background Infrared Signature Modeling for Complex Synthetic Scenes 显示文摘 | Cathcart J M | 1988 | SPIE Infrared Systems and Components1988，890，： | 1 |
| 19 | 查看详情显示文摘 | Slatter J Schaaf L Sams J Feenstra K Johnson M Bombardt P Cathcart K Verburg M Pearson L Compton L Miller L Baker D Pesheck C Lord R | | 0，，： | 1 |
| 20 | Target and Background Infrared Signature Modeling for Complex Synthetic Scenes显示文摘 | J M Cathcart | 1988 | Proceedings of SPIE1988，890，： | 1 |
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