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| 1 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 2 | Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin,TGF-β1,IL-13 and oxidative stress显示文摘AIM To evaluate the therapeutic effects of bone marrowderived CD11b+CD14+ monocytes in a murine model of chronic liver damage. METHODS Chronic liver damage was induced in C57BL/6 mice by administration of carbon tetrachloride and ethanol for 6 mo. Bone marrow-derived monocytes isolated by immunomagnetic separation were used for therapy. The cell transplantation effects were evaluated by morphometry,biochemical assessment,immunohistochemistry and enzyme-linked immunosorbent assay. RESULTS CD11b+CD14+ monocyte therapy significantly reduced liver fibrosis and increased hepatic glutathione levels. Levels of pro-inflammatory cytokines,including tumor necrosis factor-α,interleukin(IL)-6 and IL-1β,in addition to pro-fibrotic factors,such as IL-13,transforming growth factor-β1 and tissue inhibitor of metalloproteinase-1 also decreased,while IL-10 and matrix metalloproteinase-9 increased in the monocytetreated group. CD11b+CD14+ monocyte transplantation caused significant changes in the hepatic expression of α-smooth muscle actin and osteopontin. CONCLUSION Monocyte therapy is capable of bringing about improvement of liver fibrosis by reducing oxidative stress and inflammation,as well as increasing antifibrogenic factors. | Veruska Cintia Alexandrino de Souza Thiago Almeida Pereira Valéria Wanderley Teixeira Helotonio Carvalho Maria Carolina Accioly Brelaz de Castro Carolline Guimaraes D’assuncao Andreia Ferreira de Barros Camila Lima Carvalho Virgínia Maria Barros de Lorena Vláudia Maria Assis Costa Alvaro Aguiar Coelho Teixeira Regina Celia Bressan Queiroz Figueiredo Sheilla Andrade de Oliveira | 2017 | World Journal of Gastroenterology2017，23，28： | 6 |
| 3 | 非运动症状负担、情绪和步态障碍是导致帕金森病非痴呆患者生活质量下降的最重要因素显示文摘帕金森病存在多种运动和非运动症状表现,其中非运动症状对于帕金森病患者生活质量的影响更为严重。改善帕金森病非运动症状,有助于提高患者的生活质量。既往帕金森病非运动症状研究多为单中心小样本研究,所涉及的非运动症状类型较为局限,无法全面反映非运动症状对帕金森病患者生活质量的影响。为此,该研究通过分析COPPADIS-2015研究队列来关注帕金森病患者非运动症状对其生活质量的影响。该队列是西班牙全国范围内为期5年的多中心综合观察性随访队列研究。 | 张煜(编译) Santos Garcia D de Deus Fonticoba T Suarez Castro E | 2020 | 中华医学杂志2020，100，27： | 3 |
| 4 | 非甾体抗炎药应用中,环氧合酶2、不对称二甲基精氨酸与心血管危害的关系显示文摘已有大规模、安慰剂对照试验确定了非甾体类抗炎药(nonsteroidal anti—inflammatory drugs,NSAIDs)具有心血管危害性:这归因于环氧合酶2(cyclooxygenase,COX-2)的心脏保护产物受到抑制,尤其是前列环素(prostacyclin,PG12)。NSAID降低心脏保护作用的另一种机制可能是通过增强肾脏中甲基精氨酸的形成来限制一氧化氮在整个脉管系统中的作用。 | Ricciotti E Castro C Tang SY Briggs WTE West JA Malik D Rhoades SD Meng H Li X Lahens NF Sparks JA Karlson EW Weljie AM Griffin JL FitzGerald GA6 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 3 |
| 5 | Tm(DOTP)5- :a 23 Na+ shift agent for perfused rat hearts显示文摘 | Buster D C Castro M M Geraldes C F | 1990 | Magn Reson Med1990，15，： | 2 |
| 6 | Reduction of ethyl benzoylacetate and selective protection of 2- (3-hydroxy-1- phenylpropyl) -4-methylphenol: A new and facile synthesis of tolterodine 显示文摘 | De Castro KA Ko J Park D | 2007 | Org Process Res Dev2007，11，5： | 1 |
| 7 | Learning and optimization using the clonal selection principle 显示文摘 | Castro L N D Von Zuben F J | 2002 | IEEE Transactions on Evolutionary Computation2002，6，3： | 1 |
| 8 | Sequential (step-by-step) detection, identification and quantitation of extra virgin olive oil adulterationby chemometric treatment of chromatographic profiles 显示文摘 | F Priego Capot J Ruiz Jira6nez M D Luque de Castro | 2007 | Anal Bioanal Chem2007，388，： | 1 |
| 9 | Fully automated method for the determination of 24,25(OH)D_3 hydroxyvitamins,and Vitamins A and E in human serum by HPLC显示文摘 | Mata-Granados J M Luquede Castro M D Quesada J M | 2004 | Journal of Pharmaceutical and Biomedical Analysis2004，35，： | 1 |
| 10 | The central nervous system and cardiovascular effects of levobupivacaine and ropivacaine in healthy volunteers显示文摘 | Stewart J Kellett N Castro D | 2003 | Anesth Analg2003，97，2： | 1 |
| 11 | Ultrasound-assisted dynamic extraction of valuable compounds from aromatic plants and flowers as compared with steam distillation and superheated liquid extraction显示文摘 | Roldan-Gutierrez J M Ruiz-Jimenez J Luque de Castro M D | 2008 | Talanta2008，75，5： | 1 |
| 12 | Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis:requirement for Akt activation显示文摘 | Del Bufalo D Di Castro V Biroccio A | 2002 | Mol Pharmacol2002，61，： | 1 |
| 13 | Determination of selenium in nutritional supplements and shampoos by flow injection-hydride generation-atomic fluorescence spectrometry 显示文摘 | Gomiz-Gracia L Luque De Castro M D | 1999 | Talanta1999，50，4： | 1 |
| 14 | A novel muta-tion in the growth and differentiation factor 9 (GDF9)gene is associated, in homozygosis, with increased ovula-tion rate in Santa Ines sheep 显示文摘 | Melo E O Silva B D M Castro E A | 2008 | Biology of Reproduction2008，78，141： | 1 |
| 15 | New oxidation catalysts based on iron(III) porphyrins immobilized on Mg-Al layered double hydroxides modified with triethanolamine 显示文摘 | CASTRO K A D F BAIL A GROSZEWICZ P B MACHADO G S SCHREINER W H WYPYCH F NAKAGAKI S | 2010 | Appl Catal A: Gen2010，386，： | 1 |
| 16 | Fabrication of Double Shell Targets with a Glass Inner Capsule Supported by SiO2 Aerogel for Shots on the Omega Laser in 2006 显示文摘 | Bono M Bennett D Castro C | 2006 | Fusion Science and Technology2006，51，4： | 1 |
| 17 | Role of blossoms in watermelon seed infestation by Acidovorax avenae subsp, cit- rulli 显示文摘 | Walcott R R Gitaitis R D Castro A (2 | 2003 | PhvtoDatholo:v2003，93，5： | 1 |
| 18 | Structural, morphological and surface properties as a function of composition of Ru + Ti + Pt mixed-oxided electrodes 显示文摘 | LASSALI T A F CASTRO S C D BOODTS J F C | 1998 | Electrochimica Acta1998，43，1617： | 1 |
| 19 | Symmetry of Below-ground Competition Between Kochia Scoparia Individuals 显示文摘 | Weiner J Wright D B Castro S | 1997 | Oikos1997，，79： | 1 |
| 20 | The influence of market heterogeneity on the relationship between a destination's image and tourists' future behaviour显示文摘 | Castro C B Armario E M Ruiz D M | 2007 | Tourism Management2007，28，1： | 1 |
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