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	题名	作者	年代	出处	被引量
1	Effects of six months losartan administration on liver fibrosis in chronic hepatitis C patients: A pilot study显示文摘AIM: To evaluate the safety and efficacy of chronic administration of losartan on hepatic fibrosis in chronic hepatitis C patients. METHODS: Fourteen patients with chronic hepatitis C non-responders (n = 10), with contraindications (n = 2) or lack of compliance (n = 2) to interferon plus ribavirin therapy and liver fibrosis were enrolled. Liver and renal function test, clinical evaluation, and liver biopsies were performed at baseline and after losartan administration at a dose of 50 mg/d during the 6 mo. The control group composed of nine patients with the same inclusion criteria and paired liver biopsies (interval 6-14 mo). Histological activity index (HAI) with fibrosis stage was assessed under blind conditions by means of Ishak's score. Subendothelial fibrosis was evaluated by digital image analyses. RESULTS: The changes in the fibrosis stage were significantly different between losartan group (decrease of 0.5±1.3) and controls (increase of 0.89±1.27; P<0.03). In the treated patients, a decrease in fibrosis stage was observed in 7/14 patients vs 1/9 control patients (P<0.04). A decrease in sub-endothelial fibrosis was observed in the losartan group. No differences were found in HAI after losartan administration. Acute and chronic decreases in systolic arterial pressures (P<0.05) were observed after the losartan administration, without changes in mean arterial pressure or renal function. CONCLUSION: Chronic AT-Ⅱ type 1 receptor (AT1R) blockade may reduce liver fibrosis in patients with chronic hepatitis C.	Silvia Sookoian María Alejandra Fernández Gustavo Casta(n\|~)o	2005	World Journal of Gastroenterology2005，11，48：	7
2	Nicotinic Acid Limitation Regulates Silencing of Candida Adhesins during UTI显示文摘	Domergue R Casta(n)o I de Las Pe(n)as A		0，，5723：	1
3	Determination of Nitrites in Commercial Sausages by Anthocyanins Degradation: Experimental Design and Optimization显示文摘	GAL N-VIDAL C CASTA EDA-OVANDO A P EZ-HERN NDEZ M	2014	Journal of the Mexican Chemical Society2014，58，2：	1
4	Is the increased risk ofpreterm birth following excision for cervical intraepithelialneoplasia restricted to the first birth post treatment- 显示文摘	Casta觡on A Landy R Brocklehurst P	2015	BJOG2015，122，9：	1
5	The endovaseular approach in the management of patients with multiple intracranial aneurysms显示文摘	Pierot L Boulin A Castaings L	1997	Neuroradiology1997，39，4：	1
6	Left ventricular pacing site in cardiac resynchronization therapy: clinical follow-up and predictors of failed lateral implant显示文摘	Macias A Gavira J-J Casta 5 o S	2008	European Journal of Heart Failure2008，10，：	1
7	Charges In The Hydrophobic Interior Of Proteins显示文摘	Isom Daniel G Casta eda Carlos A Cannon Brian R	2010	Proc Natl Acad Sci USA2010，107，16：	1
8	Pregnancy and Kidney Transplantation,Triple Hazard?Current Concepts and Algorithm for Approach of Preconception and Perinatal Care of the Patient With Kidney Transplantation显示文摘	L Pez L F Mart Nez C J Casta Eda D A	2014	Transplantation Proceedings2014，46，9：	1
9	Intracranial berry aneur- ysms : angiographic and clinical results after endovascular treatment 显示文摘	Cognard C Weill A Castaings L	1998	Radiology1998，206，：	1
10	Agrobacterium -mediated transformation of Musa acuminata cv. “Grand Nain” scalps by vacuum infiltration显示文摘	P.O.M. Acereto-Escoffié B.H. Chi-Manzanero S. Echeverría-Echeverría R. Grijalva A. James Kay T. González-Estrada E. Casta?o L.C. Rodríguez-Zapata	2005	Scientia Horticulturae2005，，3：	1
11	Rapid di agnosis of human brucellosis by quantitative real-time PCR:a case report of brueellar spondylitis显示文摘	Navarro-Martinez A Navarro E Casta MJ ct al	2008	J Clin Mi- erobiol2008，46，1：	1
12	Transjugular intrahepatic portosystemic shunt(TIPS) for severe veno-occlusive disease of the liver following bone marrow transplantation 显示文摘	AZOULAY D CASTAING D LEMOINE A	2000	Bone Marrow Transplant2000，25，：	1
13	Resection of nonresectable liver metastases from colorectal cancer after percutaneous portal vein embolization 显示文摘	Azoulay D Castaing D Smail A	2000	Ann Surg2000，231，4：	1
14	Scale effects in natural fracture networks显示文摘	Genter A Chilès J P	1997	International Journal of Rock Mechanics and Mining Sciences & Geomechanics Abstracts1997，34，34：	1
15	Resection of nonresectable liver metastases from colorectal liver cancer after percutaneous portal vein embolization显示文摘	Azoulay D Castaing D Smail A	2000	Ann Surg2000，231，4：	1
16	显示文摘	PAWELEC B CASTA(N)O P ZEPEDA T A	2008	Appl Surf Sci2008，254，13：	1
17	Double -codified goht nanolabels for enhanced immunoanalysis显示文摘	Ambrosi A Casta?eda MT Killard AJ Smyth MR Alegret S Merkoci A	2007	Analtical Chemistry2007，79，：	1
18	Ligand-independent regulation of the hairless promoter by vitamin D receptor显示文摘	Engelhard A Bauer RC Casta A	2008	Photochem Photobiol2008，84，2：	1
19	Circulating levels and hepatic expression of molecular mediators of atherosclerosis in nonalcoholic fatty liver disease显示文摘	Silvia Sookoian Gustavo O. Casta?o Adriana L. Burgue?o María Soledad Rosselli Tomas Fernández Gianotti Pablo Mallardi Julio San Martino Carlos Jose Pirola	2009	Atherosclerosis2009，，2：	1
20	Embolization by direct puncture of hypervascularized ORL tumors显示文摘	Pierot L Boulin A Castaings L	1994	Ann Otolaryngol Chir Cervicofac1994，111，7：	1

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