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| 1 | Fibronectin: Functional character and role in alcoholic liver disease显示文摘Fibronectins are adhesive glycoproteins that can be found in tissue matrices and circulating in various fluids of the body. The variable composition of fibronectin molecules facilitates a diversity of interactions with cell surface receptors that suggest a role for these proteins beyond the structural considerations of the extracellular matrix. These interactions implicate fibronectin in the regulation of mechanisms that also determine cell behavior and activity. The two major forms, plasma fibronectin (pFn) and cellular fibronectin (cFn), exist as balanced amounts under normal physiological conditions. However, during injury and/or disease, tissue and circulating levels of cFn become disproportionately elevated. The accumulating cFn, in addition to being a consequence of prolonged tissue damage, may in factstimulate cellular events that promote further damage. In this review, we summarize what is known regarding such interactions between fibronectin and cells that may influence the biological response to injury. We elaborate on the effects of cFn in the liver, specifically under a condition of chronic alcohol-induced injury. Studies have revealed that chronic alcohol consumption stimulates excess production of cFn by sinusoidal endothelial cells and hepatic stellate cells while impairing its clearance by other cell types resulting in the build up of this glycoprotein throughout the liver and its consequent increased availability to influence cellular activity that could promote the development of alcoholic liver disease. We describe recent findings by our laboratory that support a plausible role for cFn in the promotion of liver injury under a condition of chronic alcohol abuse and the implications of cFn stimulation on the pathogenesis of alcoholic liver disease. These findings suggest an effect of cFn in regulating cell behavior in the alcohol-injured liver that is worth further characterizing not only to gain a more comprehensive understanding of the role this reactive glycoprotein plays in the progression of injury but also for the insight further studies could provide towards the development of novel therapies for alcoholic liver disease. | Razia S Aziz-Seible Carol A Casey | 2011 | World Journal of Gastroenterology2011，17，20： | 5 |
| 2 | Re- sponses in ovulation rate, embryonal survival, and litter traits in swine to 14 generations of selection to increase litter size 显示文摘 | JOHNSON R K NIELSEN M K CASEY D S | 1999 | J Anim Sci1999，77，3： | 5 |
| 3 | Quality of life issues in men undergoing androgen deprivation therapy: a review显示文摘雄激素剥夺治疗(ADT ) 是为治疗前列腺癌症(PCa ) 的一种必要治疗选择。为神经质的治疗的角色开始被限制为人与变形、不能实行,局部地先进的疾病。现在,它为外科和放射疗法被扩大了到 neoadjuvant 或辅助治疗,为在外科或放射以后的生物化学的恶化,并且为非变形的疾病弄平同样主要的治疗。对待的百分之五十个 PCa 病人将在某点收到 ADT。关于与更普遍的 ADT 使用联系的不利效果和费用正在种担心。生活(QoL ) 的质量上的不利效果,当人们是剥夺雄激素的时,包括物理、社会、心理的健康,可能可观。这评论在下列区域检验 QoL 问题:身体女性化,性变化,关系变化,认知、感情方面的症状,疲劳,睡觉骚乱,消沉和物理效果。推进建议因为减少这些改变的治疗学的途径被建议。 | Rowan G Casey Niall M Corcoran S Larry Goldenberg | 2012 | Asian Journal of Andrology2012，14，2： | 2 |
| 4 | Cellular fi bronectin stimulates hepatocytes to produce factors that promote alcohol-induced liver injury显示文摘AIM:To examine the consequences of cellular f ibronectin(cFn)accumulation during alcohol-induced injury,and inv estigate whether increased cFn could have an effect on hepatocytes(HCs)by producing factors that could cont ribute to alcohol-induced liver injury.METHODS:HCs were isolated from rats fed a control or ethanol liquid diet for four to six weeks.Exogenous c Fn(up to 7.5 μg/mL)was added to cells cultured for 20 h,and viability(lactate dehydrogenase),apoptosis(caspase activity)and se cretion of proinflammat-ory cytokines(tumor ne c rosis fac tor alpha,TNF-α and interleukin 6,IL-6),mat rix metalloproteinases(MMPs)and their inhibitors(tissue inhibitors of metall-oproteinases,TIMPs)was det ermined.Degrad ation of iodinated cFn was det ermined over a 3 h time period in the preparations.RESULTS:cFn degradation is impaired in HCs isolated from ethanol-fed animals,leading to its accumulation in the matrix.Addition of exogenous cFn did not affect viability of HCs from control or ethanolfed animals,and apoptosis was affected only at the higher concentration.Sec retion of MMPs,TIMPs,TNF-α and IL-6,however,was increased by exogenously added cFn,with HCs from ethanolfed animals showing increased susceptibility compared to the controls.CONCLUSION:These results suggest that the elevated amounts of cFn observed in alcoholic liver injury can stimulate hepatocytes to produce factors which promote further tissue damage. | Razia S Aziz-Seible Benita L McVicker Kusum K Kharbanda Carol A Casey | 2011 | World Journal of Hepatology2011，3，2： | 2 |
| 5 | Multi-sect-ion CT angiography for detection of cerebral aneurysms显示文摘 | TEKSAM M MCKINNEY A CASEY S | 2004 | AJNR2004，25，6： | 1 |
| 6 | Rapid optimization of a peptide inhibitor of malaria parasite invasion by comprehensive N-methyl scanning显示文摘 | HARRIS K S CASEY J L COLEY A M | 2009 | J Biol Chem2009，284，14： | 1 |
| 7 | Best Practice Advance for CFD in Turbomachinery Design显示文摘 | Casey M Innotec S | 2003 | QNET-CDF Network Newsletter2003，2，3： | 1 |
| 8 | Activation in ventral prefrontal cortex is sensitive to genetic vulnerability for attention-deficit hyperactivity disorder显示文摘 | Durston S Mulder M Casey BJ | 2006 | Biol Psychiatry2006，60，10： | 1 |
| 9 | ACC/AHA clinical performance measures for adults with chronic heart failure : a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures ( Writing Committee to Develop Heart Failure Clinical Performance Measures) endorsed by the Heart Failure Society of America 显示文摘 | Bonow RO Bennett S Casey DE | 2005 | J Am Coll Cardiol2005，46，6： | 1 |
| 10 | New frontiers in food enzymology: recombinant lipoxygenases显示文摘 | Casey R West S I Hardy D David S Robinson Zecai W u Richard K Hughes | 1999 | Trends in Food Science & Technology1999，10，： | 1 |
| 11 | Diet-induced iron deficiency anemia and pregnancy outcome in rhesus monkeys显示文摘 | Mari S Casey E Alice F | | 0，，03： | 1 |
| 12 | Evaluation of the circile of Willis with three-dimensional CT angiography in patients with suspected intracranial aneurysms显示文摘 | Alerico RA Patel M Casey S | 1995 | AJNR Am J Neurorediol1995，16，8： | 1 |
| 13 | Anatomy and Frequency of Large Pontomesencephalic Veins on 3D CT Angiograms of the Circle of Willis显示文摘 | Teksam M Casey S Mckinney A | 2003 | Am J Neuroradiol2003，24，12： | 1 |
| 14 | Responses in ovulation rate, embryonal survival, and litter traits in swine to 14 generations of selection to increase litter size 显示文摘 | JOHNSON R K NIELSEN M K CASEY D S | 1999 | J Anim Sci1999，77，3： | 1 |
| 15 | Posterior reversible encephalopathy syndrome: utility of fluid-atten- uated inversion recovery MR imaging in the detection of cortical and subcortical lesions 显示文摘 | CASEY S O SAMPAIO R C MICHEL E | 2000 | Am J Neuroradiol2000，21，7： | 1 |
| 16 | Cyclooxygenase-2and thromboxane synthase in non-endocrine and endocrine tumors : a review 显示文摘 | ONGURU O CASEY M B KAJITA S | 2005 | Endocr Pathol2005，16，4： | 1 |
| 17 | Weekly compared with daily blood glucose monitoring in women with diet-treated gestational diabetes显示文摘 | HAWKINSJ S CASEY B M LO J Y | 2009 | Obstet Gynecol2009，113，6： | 1 |
| 18 | Fluid mechanics of heart valves显示文摘 | Yoganathan A P He Z Casey Jones S | 2004 | Annu Rev Biomed Eng2004，6，： | 1 |
| 19 | Comparison of human cerebral activation pattern during cutaneous warmth, heat pain, and deep cold pain显示文摘 | Casey K L Minoshima S Morrow T J | 1996 | J Neurophysiol1996，76，1： | 1 |
| 20 | N - acetyl - 1 - cysteine Supplementation Improves Boar Spermatozoa Characteristics and Subsequent Fertilization and Embry- onic Development 显示文摘 | Whitaker B D Casey S J Taupier R | 2012 | Reproduction in Domestic An- imals2012，47，2： | 1 |
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