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| 1 | Presacral venous bleeding during mobilization in rectal cancer显示文摘AIM To analyze the anatomy of sacral venous plexus flow, the causes of injuries and the methods for controlling presacral hemorrhage during surgery for rectal cancer.METHODS A review of the databases MEDLINE? and Embase? was conducted, and relevant scientific articles published between January 1960 and June 2016 were examined. The anatomy of the sacrum and its venous plexus, as well as the factors that influence bleeding, the causes of this complication, and its surgical management were defined.RESULTS This is a review of 58 published articles on presacral venous plexus injury during the mobilization of the rectum and on techniques used to treat presacral venous bleeding. Due to the lack of cases published in the literature, there is no consensus on which is the best technique to use if there is presacral bleeding during mobilization in surgery for rectal cancer. This review may provide a tool to help surgeons make decisions regarding how to resolve this serious complication.CONCLUSION A series of alternative treatments are described; however, a conventional systematic review in which optimal treatment is identified could not be performed because few cases were analyzed in most publications. | Jose Enrique Casal Núnez Vincenzo Vigorita Alejandro Ruano Poblador Ana María Gay Fernández Maria ángeles Toscano Novella Nieves Cáceres Alvarado Lucinda Pérez Dominguez | 2017 | World Journal of Gastroenterology2017，23，9： | 4 |
| 2 | Functional Heterogeneity of Cancer-Associated Fibroblasts from Human Colon Tumors Shows Specific Prognostic Gene Expression Signature显示文摘 | Mercedes Herrera Abul B.M.M.K. Islam Alberto Herrera Paloma Martín Vanesa García Javier Silva Jose M. Garcia Clara Salas Ignacio Casal Antonio García de Herreros Félix Bonilla Cristina Pe?a | 2013 | Clinical Cancer Research2013，，21： | 2 |
| 3 | Combination of hot water, Bacillus subtilis CPA-8 and sodium bicarbonate treatments to control postharvest brown rot on peaches and nectarines 显示文摘 | Casals C Teixide N Vinas I | 2010 | European Journal of Plant Pathology2010，128，1： | 1 |
| 4 | Vitamin A and betacarotene can im- prove nonheme iron absorption from rice,wheat and corn by hu- mans显示文摘 | GARCIA CASAL M N | 1988 | American Journal of Clinical Nutrition1988，，47： | 1 |
| 5 | Design and analysis of the IFMIF-EVEDA beam dump cooling system显示文摘 | PARRO M CASAL N IGLESIAS D | 2012 | Fusion Engineering and Design2012，87，： | 1 |
| 6 | Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer显示文摘Colorectal cancer(CRC)is the second leading cause of cancer-related death worldwide.The five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced stages.Autoantibodies against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early diagnosis.Thus,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid biopsy.To that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to CRC.After bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC prognosis.After validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC detection.Taken together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here could be integrated into a point-of-care(POC)device for CRC detection with high diagnostic ability. | Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo Sanz Jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo Barderas | 2021 | Engineering2021，7，10： | 1 |
| 7 | Standardization of M-mode Echocardiographic Left Ventricular Anatomic Measurements显示文摘 | Deverux R B Lutas E M Casale P N | 1984 | J Am Coil Cardiol1984，4，： | 1 |
| 8 | Comparison of sero-logic tests used in canine brucellosis diagnosis显示文摘 | Mateu-de-Antonio E M Martín M Casal J | 1994 | J Vet DiagnInvest1994，6，2： | 1 |
| 9 | Measurement of the External Surface Area of Powders by a Permeametric Method显示文摘 | J Casal J Arnaldos N Pellicer | 1989 | Powder Technology1989，58，： | 1 |
| 10 | Detec- tion of minced beef adulteration with turkey meat by UV vis, NIR and MIR spectroscopy 显示文摘 | Alamprese C Casale M Sinelli N | 2013 | LWT-Food Science and Technology2013，53，1： | 1 |
| 11 | Selective recovery of glycosylated caseinmacropeptide with chitosan显示文摘 | CASAL E CORZO N MORENO F J | 2005 | Journal of Agricultural and Food Chemistry2005，53，4： | 1 |
| 12 | Transfer of socially com- plex knowledge in mergers and acquisitions显示文摘 | CASAL C C FONTELA E N | 2007 | Journal of Knowledge Management2007，11，4： | 1 |
| 13 | Evaluation of a non-chlorofluorocarbon formulation of cromolyn sodi-urn (Imal) metered-dose intmler versus the chlorofluoro-carbon formulation in the treatment of adult patients with asthma: a controlled trial 显示文摘 | Blumenthal M N Casale T B Fink J N | 1998 | J Allergy Clin Immumol1998，101，1： | 1 |
| 14 | Using RxNorm for Cross -institutional Formulary Data Normalization within a Distributed Grid-computing Environment显示文摘 | Wynden R Anderson N Casale M | 2011 | AMIA Annu Symp Proc2011，，： | 1 |
| 15 | Sirluins in vascular diseases: Emerging roles and therapeutic potential 显示文摘 | D'Onofrio N Vitiello M Casale R et aI | 2015 | Biochim Biophys Acta2015，1852，7： | 1 |
| 16 | Optimisation of a new headspace mass spectrometry instrument显示文摘 | Concepción Cerrato Oliveros Raffaella Boggia Monica Casale Carla Armanino Michele Forina | 2005 | Journal of Chromatography A2005，，1： | 1 |
| 17 | Frequency analysis of hazardous material transportation incidents as a function of distance from origin to incident location显示文摘 | C Samuel N Keren M C Shelley Steven A Freeman Joaquim Casal | 2009 | Journal of Loss Prevention in the Process Industries2009，22，6： | 1 |
| 18 | Detection of minced beef adulteration with turkey meat by UV-vis, NIR and MIR spectroscopy 显示文摘 | Alamprese C Casale M Sinelli N | 2013 | LWT -Food Science and Tech- nology2013，53，1： | 1 |
| 19 | Aquaporin-3 expression in human fetal airway epithelial progenitor cells显示文摘 | Avril-Delplanque A Casal I Castillon N | 2005 | Stem Cells2005，23，7： | 1 |
| 20 | Multipleallergen and single-allergen immunotherapy strategies in polysensitized patients:looking at the published evidence显示文摘 | Calderón MA Cox L Casale TB | 2012 | J Allergy Clin Immunol2012，129，： | 1 |
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