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| 1 | Triptolide (PG-490) induces apoptosis of dendritic cells through sequential p38 MAP kinase phosphorylation and caspase 3 activation显示文摘Dendritic cells (DCs) are the most potent antigen-presen ting cells that play crucial roles in the regulation of immune response. Triptol ide, an active component purified from the medicinal plant Tripterygium wilfor dii Hook F., has been demonstrated to act as a potent immunosuppressive drug c apab le of inhibiting T cell activation and proliferation. However, little is known a bout the effects of triptolide on DCs. The present study shows that triptolide d oes not affect phenotypic differentiation and LPS-induced maturation of murine DCs. But triptolide can dramatically reduce cell recovery by inducing apoptosis of DCs at concentration as low as 10 ng/ml, as demonstrated by phosphatidylserin e exposure, mitochondria potential decrease, and nuclear DNA condensation. Tript olide induces activation of p38 in DCs, which precedes the activation of caspase 3. SB203580, a specific kinase inhibitor for p38, can block the activation of caspase 3 and inhibit the resultant apoptosis of DCs. Our results suggest that t he anti-inflammatory and immunosuppressive activities of triptolide may be due, in part, to its apoptosis-inducing effects on DCs. | LiuQ ChenT ChenH ZhangM LiN LuZ MaP CaoX | 2004 | 第二军医大学学报2004，25，9： | 41 |
| 2 | Identification of an HLA-A~* 0201-restricted CD8^+ T-cell epitope SSp-1 of SARS-CoV spike protein显示文摘A novel coronavirus, severe acute respiratory syndrome (SA RS)-associated coronavirus (SARS-CoV), has been identified as the causal agent of SARS. Spike (S) protein is a major structural glycoprotein of the SARS virus and a potential target for SARS-specific cell-mediated immune responses. A pa nel of S protein-derived peptides was tested for their binding affinity to HLA -A *0201 molecules. Peptides with high affinity for HLA-A *0201 were then as se ssed for their capacity to elicit specific immune responses mediated by cytotoxi c T lymphocytes (CTLs) both in vivo, in HLA-A2.1/K b transgenic mice, a nd in vitro, from peripheral blood lymphocytes (PBLs) harvested from healthy HLA-A 2.1 + donors. SARS-CoV protein-derived peptide-1 (SSp-1 RLNEVAKNL), induced pepti de-specific CTLs both in vivo (transgenic mice) and in vitro (human PBL s), which specifically released interferon-gamma (IFN-gamma) upon stimulation with SSp-1-pulsed autologous dendritic cells (DCs) or T2 cells. SSp-1-specif ic CTLs also lysed major histocompatibility complex (MHC)-matched tumor cell lines engineered to express S proteins. HLA-A *0201-SSp-1 tetramer staining re vealed the presence of significant populations of SSp-1-specific CTLs in SSp- 1-induced CD8 + T cells. We propose that the newly identified epitope SSp-1 w ill help in the characterization of virus control mechanisms and immunopathology in SARS-CoV infection, and may be relevant to the development of immunotherape utic approaches for SARS. | WangB ChenH JiangX ZhangM WanT LiN ZhouX WuY YangF YuY WangX YangR CaoX | 2004 | 第二军医大学学报2004，25，9： | 21 |
| 3 | A Review of Lignocellulosic Biomass Pretreatment Technologies显示文摘Lignocellulose is the most abundant renewable resource on earth.However,owing to the tightly entangled structural characteristics,it is challenging to convert lignocellulose into bio-based products in the biorefinery process without pretreatment.Pretreatment can destroy the natural resistance structure of lignocellulosic biomass,which is conducive to its downstream enzymatic saccharification and fermentation process.Physical,chemical,and physicochemical pretreatments have been widely conducted for lignocellulosic biomass;several updated approaches and peculiar chemicals have also been proposed for these pretreatment methods in the recent years.Hence,this study comprehensively reviews the novel technologies and chemicals that were applied in the various pretreatments.In addition,the mechanisms,advantages,and disadvantages of the updated pretreatments are discussed to provide a reference for developing new pretreatment methods. | Caoxing Huang Jiao Liu Wenhui Geng Wei Tang Qiang Yong | 2021 | Paper And Biomaterials2021，6，3： | 3 |
| 4 | Concepts and key techniques for 30 m global land cover mapping显示文摘 | ChenJ(陈军) ChenJ(陈晋) LiaoAP(廖安平) CaoX(曹鑫) ChenLJ(陈利军) ChenXH(陈学泓) PengS(彭舒) HanG(韩刚) ZhangHW(张宏伟) HeCY(何超英) WuH(武昊) LuM(陆苗) | | 测绘学报0，，2014： | 2 |
| 5 | Effects of XinFu- Kang oral liquid on the activities of respiratory enzyme in experimental congestive heart failure rats 显示文摘 | WangW W CaoX B Xu S L | 2010 | Heart2010，96，3： | 1 |
| 6 | Conserved plant genes with similarity to mammalian de novo methyltransferases显示文摘 | CaoX Springer NM Muszynski MG | 2000 | Proc Natl Acad Sci USA2000，97，： | 1 |
| 7 | Circulating dendritic cells subsets and CD4 Foxp3 regulatory T cells in aduh patients with chronic ITP before and after treatment with high-dose dexamethasome 显示文摘 | Ling Y CaoX Yu Z | 2007 | EurJ Haemato12007，79，4： | 1 |
| 8 | 显示文摘 | Zhu L Meng J CaoX Q | 2007 | Eur J Inorg Chem2007，2007，24： | 1 |
| 9 | 显示文摘 | 贾翀(JiaC) 程秀才(ChengXC) 曹轩(CaoX) 田野(TianY) 杨雨微(YangYW) 张洋(ZhangY) 崔举庆(CuiJQ) | | 林业科技开发0，，： | 1 |
| 10 | GranzymeBand perforin are important for regulatory T cell mediated suppression of tumor clearance显示文摘 | CaoX CaiSF FehnigerTA | 2007 | Immunity2007，27，4： | 1 |
| 11 | Ionicliquid-basedultrasonic-assisted extraction of piperine from white pepper显示文摘 | CAOX YEX LUY etal | 2009 | Analytica Chimica Acta2009，640，12： | 1 |
| 12 | Hybrid fiberlaser-arc welding of thick section high strength low alloysteel显示文摘 | CAOX WANJARA P HUANG J | 2011 | Materials and Design2011，32，6： | 1 |
| 13 | Encapsulation of plasmid DNA in calcium phosphatenanoparticles: stem cell uptake and gene transfer efficiency显示文摘 | CaoX Derig W Wei Y Su W Yang Y Wei Y Yu J Xu X | 2011 | Int J Nanomedicine2011，6，： | 1 |
| 14 | Morphological features of oncosisand apoptosis of germ cells 显示文摘 | CAOX LIC YUANC | 2010 | 中国男科学杂志2010，24，10： | 1 |
| 15 | Semi - preparaive Separation and Purification of taxol analogs by High - speed counter current chromatography 显示文摘 | CaoX Tian Y ZhangTY | 1998 | Prep Biochem Biotechnol1998，28，1： | 1 |
| 16 | Property (ω1) and Weyl type theorem显示文摘 | SUNC H CAOX H DAI L | 2010 | J Math Anal2010，363，1： | 1 |
| 17 | Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant显示文摘Heat shock proteins (HSPs) are reported to act as effective adjuvants to elicit anti-tumor and anti-infection immunity. Here, we report that Hsp70-like protein 1 (Hsp70L1), a novel HSP derived from human dendritic cells (DCs), has potent adjuvant effects that polarize responses toward Th1. With a calculated molecular weight of 54.8 kDa, Hsp70L1 is smaller in size than Hsp70 but resembles it both structurally and functionally. Hsp70L1 shares common receptors on DCs with Hsp70 and can interact with DCs, promoting DC maturation and stimulating secretion of the proinflammatory cytokines interleukin 12p70 (IL-12p70), IL-1beta, tumor necrosis factor-alpha (TNF-alpha), and the chemokines IP-10, macrophage inflammatory protein-1alpha (MIP-1alpha), MIP-1beta, and normal T cell expressed and secreted (RANTES). The induction of interferon-gamma-inducible protein 10 (IP-10) secretion by Hsp70L1 is not shared by Hsp70, and other functional differences include more potent stimulation of DC IL-12p70, CC-chemokine, and CCR7 and CXCR4 expression by Hsp70L1. Immunization of mice with the hybrid peptide Hsp70L1-ovalbumin(OVA)(257-264) induces an OVA(257-264)-specific Th1 response and cytotoxic T lymphocyte (CTL) that results in significant inhibition of E.G7-OVA tumor growth. The ability of Hsp70L1 to activate DCs indicates its potential as a novel adjuvant for use with peptide immunizations; the Hsp70L1 antigen peptide hybrid may serve as a more effective vaccine for the control of cancer and infectious diseases. | WanT ZhouX ChenG AnH ChenT ZhangW LiuS JiangY YangF WuY CaoX | 2005 | 第二军医大学学报2005，26，7： | 1 |
| 18 | Dairy-manurederivedbio-chareffectivelysorbsleadandatrazine显示文摘 | CAOX MAL GAOB etal | 2009 | ES& T2009，43，9： | 1 |
| 19 | Eliciting T cell immunity against porrly immunogenic tumor by immunization with de-ndritic cell-tumor fusion vaccines 显示文摘 | Saffolds CaoX | 1998 | J Immunol1998，161，10： | 1 |
| 20 | 5′FlankingsequenceandgenomicstructureofEgr-1,amurinemitogeninducibleZincfingerencodinggene显示文摘 | Hwa-Chon Morris-Tsai CaoX etal | 1988 | NucleicAcidsRes1988，16，18： | 1 |
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