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| 1 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 2 | Evaluation of a laparoscopic liver resection in the setting of cirrhosis显示文摘 | Robert M Cannon Bob Saggi Joseph F Buell | 2014 | HPB2014，，2： | 3 |
| 3 | Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer ' s disease显示文摘 | Bard F Cannon C Barbour R | 2000 | Nat Med2000，6，8： | 2 |
| 4 | Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer' s disease-like neuropathology显示文摘 | Bard F Barbour R Cannon C | 2003 | Proc Natl Acad Sci USA2003，100，4： | 1 |
| 5 | Surgical resection for hilar cholangiocarcinoma: experience improves resectability 显示文摘 | Cannon R M Brock G Buell J F | 2012 | HPB (Oxford)2012，14，2： | 1 |
| 6 | Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer's disease 显示文摘 | Bard F Cannon C Barbour R | 2000 | Nature Medicine2000，6，8： | 1 |
| 7 | The effects of leptinon breastfeeding behaviour显示文摘 | Cannon AM Kakulas F Hepworth AR | 2015 | International Journal of Environ-mental Research and Public Health2015，12，10： | 1 |
| 8 | Epitode and isotype specificities of antibodies toβ-amyloid peptide for protection against Alzheimer's disease-like neuropathology 显示文摘 | Bard F Barbour R Cannon C | 2003 | Proc Natl Acad Sci USA2003，100，4： | 1 |
| 9 | Colletotrichum: complex species or species complexes 显示文摘 | DAMM U CANNON P F CROUS P W | 2012 | Studies in Mycology2012，73，1： | 1 |
| 10 | Evaluation of hydrocarbon emission characteristics of typical carbonaceous additives in green sand foundries 显示文摘 | Wang Y J Huang H Cannon F S | 2007 | Environmental Science & Technology2007，41，： | 1 |
| 11 | Metallogeny of the Midcontinent rift system of North America 显示文摘 | Nicholson S W Cannon W F Schulz K J | 1992 | Precambrian Re- search1992，58，14： | 1 |
| 12 | Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double- blind trial 显示文摘 | Zannad F Cannon CP Cushman WC | 2015 | Lancet2015，35，82： | 1 |
| 13 | Crustal scale thrusting and origin of the Montreal River monocline - A 5 - km - thick cross section of the Midcontinent rift in northern Michigan and Wisconsin 显示文摘 | Cannon W F Petennan Z E Sims P K | 1993 | Tectonics1993，12，： | 1 |
| 14 | Rail Roiling Contact Fatigue Research by the European Rail Research Institute 显示文摘 | CANNON D F PRADIER H | 1996 | Wear1996，191，12： | 1 |
| 15 | Characterization of hydrocarbon emissions from green sand foundry core binders by analytical pyrolysis 显示文摘 | Wang Y J Cannon F S Salama M | 2007 | Environmental Science & Technology2007，41，： | 1 |
| 16 | The Colletotrichum boninense species complex 显示文摘 | Damm U Cannon P F Woudenberg J H C | 2012 | Studies in Mycology2012，73，： | 1 |
| 17 | Colletrotrichum names in current use显示文摘 | Hyde K D Cai L Cannon P F et ol | 2009 | Fungal Diversity2009，39，： | 1 |
| 18 | Colletotrichum- current status and future directions 显示文摘 | Cannon P F DammU Johnston P R | 2012 | Studies in Mycology2012，73，1： | 1 |
| 19 | Adsorption and coprecipitation of copper with the hydrous oxides of iron and aluminum显示文摘 | Karthikeyan K G Elliott H A Cannon F S | 1997 | Environmental Science and Technology1997，31，10： | 1 |
| 20 | A revision of the genus Neo- cosmospora (Hypocreales)显示文摘 | Cannon P F Hawksworth D L | 1984 | Transactions of the British My- cological Society1984，82，： | 1 |
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