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| 1 | Normal and abnormal spine and thoracic cage development显示文摘Development of the spine and thoracic cage consists of a complex series of events involving multiple metabolic processes, genes and signaling pathways. During growth, complex phenomena occur in rapid succession. This succession of events, this establishment of elements, is programmed according to a hierarchy. These events are well synchronized to maintain harmonious limb, spine and thoracic cage relationships, as growth in the various body segments does not occur simultaneously at the same magnitude or rate. In most severe cases of untreated progressive earlyonset spinal deformities, respiratory insufficiency and pulmonary and cardiac hypertension(cor pulmonale), which characterize thoracic insufficiency syndrome(TIS), can develop, sometimes leading to death. TIS is the inability of the thorax to ensure normal breathing. This clinical condition can be linked to costo-vertebral malformations(e.g., fused ribs, hemivertebrae, congenital bars), neuromuscular diseases(e.g., expiratory congenital hypotonia), Jeune or Jarcho-Levin syndromes or to 50% to 75% fusion of the thoracic spine before seven years of age. Complex spinal deformities alter normal growth plate development, and vertebral bodies become progressively distorted, perpetuating the disorder. Therefore, many scoliotic deformities can become growth plate disorders over time. This review aims to provide a comprehensive review of how spinal deformities can affect normal spine and thoracic cage growth. Previous conceptualizations are integrated with more recent scientific data to provide a better understanding of both normal and abnormal spine and thoracic cage growth. | Federico Canavese Alain Dimeglio | 2013 | World Journal of Orthopedics2013，4，4： | 12 |
| 2 | 闭合复位动态石膏固定治疗儿童发育性髋关节发育不良的疗效分析显示文摘目的研究闭合复位动态石膏固定治疗儿童发育性髋关节发育不良(developmental dysplasia of the hip,DDH)的疗效。方法回顾性分析广州市妇女儿童医疗中心儿童骨科采用闭合复位动态石膏固定治疗DDH患儿276例(308髋),其中男童35例,女童241例;复位时平均年龄(15. 3±4. 4)个月。门诊定期行X线检查,记录再脱位发生率,采用Kalamchi-MacEwen法评估髋关节有无股骨头缺血性坏死(avascular necrosis,AVN),以及AVN的分型。末次随访时采用Severin评级对髋关节进行分级。结果本研究发现276例(308髋) DDH患儿再脱位发生率为5. 5%。T9nnisⅡ度的髋关节再脱位发生率低于T9nnisⅢ度和Ⅳ度,差异有统计学意义(P=0. 027)。总体AVN发生率为11. 7%,其中Ⅱ型22髋,Ⅲ型11髋,Ⅳ型3髋。末次随访时髋臼指数平均为(21. 0±6. 1)°。79. 9%的髋关节获得满意结果(74. 4%Severin评级为Ⅰ级,5. 5%为Ⅱ级); 20. 1%的髋关节结局为不满意(19. 1%Severin评级为Ⅲ级,1%为Ⅳ级)。结论 DDH闭合复位后采用动态石膏固定可以获得良好的疗效,该固定方式不会增加再脱位和AVN的发生率。 | 周庆和 黎艺强 刘远忠 陈伟东 李敬春 Federico Canavese 徐宏文 | 2018 | 临床小儿外科杂志2018，17，10： | 8 |
| 3 | 'Y'型软骨未闭合儿童股骨颈骨折术后股骨近端骺板早闭的风险因素分析显示文摘目的探讨'Y'型软骨未闭合儿童股骨颈骨折术后股骨近端骺板早闭(premature proximal femur physeal closure,PPC)的风险因素。方法回顾性分析2010年3月至2017年5月采用手术治疗的106例'Y'型软骨未闭合股骨颈骨折患儿资料,记录患儿的年龄、性别、侧别、受伤机制、骨折分型、移位程度、手术时机、固定方式、有无过骺板固定、复位方式、复位质量和末次随访时有无股骨头坏死等可疑风险因素。术后6~12个月通过X线片评估有无PPC的发生。结果106例患儿均得到随访,随访时间(20.4±13.3)个月(范围6~86个月)。其中39例患儿股骨颈骨折术后发生PPC,发生率为36.8%(39/106)。发生PPC的患儿39例,男25例,女14例;年龄(9.7±3.6)岁(范围3~15岁);左侧23例,右侧16例;交通伤5例,高处坠落伤21例,运动伤12例,其他类型损伤1例;DelbetⅠ型2例,Ⅱ型26例,Ⅲ型11例;移位程度Ⅱ度26例,Ⅲ度13例;受伤至手术时间(3.3±2.8)d(范围1~14 d);克氏针固定2例,螺钉固定35例,钢板固定2例;过骺板固定2例,未过骺板固定37例;闭合复位15例,开放复位24例;解剖复位14例,可接受复位24例,不可接受复位1例;末次随访时24例出现股骨头坏死,余15例无股骨头坏死。统计学分析显示,有PPC的患儿年龄(t=3.875,P<0.001)、移位程度(Z=-2.118,P=0.034)和股骨头坏死的发生率(χ^2=42.280,P<0.001)均大于无PPC的患儿,差异均有统计学意义;其余各因素两者比较差异均无统计学意义。Logistic回归分析结果显示,年龄(OR=1.288,P=0.011)和股骨头坏死(OR=40.336,P<0.001)是儿童股骨颈骨折术后发生PPC的独立风险因素。ROC曲线分析提示年龄>10岁会增加PPC的风险。年龄≥10岁的患儿PPC发生率(63.6%,21/33)高于年龄<10岁的患儿(24.7%,18/73)(χ^2=14.848,P<0.001)。结论年龄≥10岁和股骨头坏死是'Y'型软骨未闭合儿童股骨颈骨折术后股骨近端骺板早闭的风险因素。 | 汪文涛 黎艺强 郭跃明 李明 梅海波 熊竹 邵景范 李进 陈顺有 Federico Canavese | 2021 | 中华骨科杂志2021，41，2： | 6 |
| 4 | Serial elongation-derotation-flexion casting for children with early-onset scoliosis显示文摘Various early-onset spinal deformities, particularly infantile and juvenile scoliosis(JS), still pose challenges to pediatric orthopedic surgeons. The ideal treatment of these deformities has yet to emerge, as both clinicians and surgeons still face multiple challenges including preservation of thoracic motion, spine and cage, and protection of cardiac and lung growth and function. Elongation-derotation-flexion(EDF) casting is a technique that uses a custom-made thoracolumbar cast based on a three-dimensional correction concept. EDF can control progression of the deformity and- in some cases-coax the initially-curved spine to grow straighter by acting simultaneously in the frontal, sagittal and coronal planes. Here we provide a comprehensive review of how infantile and JS can affect normal spine and thorax and how serial EDF casting can be used to manage these spinal deformities. A fresh review of the literature helps fully understand the principles of the serial EDF casting technique and the effectiveness of conservative treatment in patients with early-onset spinal deformities, particularly infantile and juvenile scolisois. | Federico Canavese Antoine Samba Alain Dimeglio Mounira Mansour Marie Rousset | 2015 | World Journal of Orthopedics2015，6，11： | 2 |
| 5 | Fire retardant halogen - antimony - clay synergism in polypropylene layered ailicate nanocomposites 显示文摘 | Zanetti M Camino G Canavese D | 2002 | Chemical Material2002，14，： | 1 |
| 6 | Vascular endothelial growth factor (VEGF) in the pathogenesis of psoriasis-a possible target for novel therapies? 显示文摘 | Canavese M Altruda F Ruzicka T | 2010 | J Dermatol Sci2010，58，3： | 1 |
| 7 | Accuracy of sentinel lymph node biopsy after neo-adjuvant chemotherapy in patients with locally advanced breast cancer and clinically positive axillary nodes显示文摘 | Canavese G Dozin B Vecchio C | 2011 | EJSO2011，37，8： | 1 |
| 8 | Risk management of renal biopsy:1387 cases over 30 years in a single centre显示文摘 | Canavese C Marengo M | 2007 | Eur J Clin Invest2007，37，12： | 1 |
| 9 | Functional results of displaced proximal humerus fractures in children treated by elastic stable intramedullary nail显示文摘 | A. Khan L. Athlani M. Rousset A. Samba F. Canavese | 2014 | European Journal of Orthopaedic Surgery & Traumatology2014，，2： | 1 |
| 10 | Cryptorchidism: medical and surgical treatment in the 1st year of life显示文摘 | Canavese F Cortese MG Magro P | 1998 | Pedlatr Surg Int1998，14，： | 1 |
| 11 | Pregnancy in kidney transplantation: satisfactory outcomes and harsh realities 显示文摘 | Stratta P Canavese C Giacchino F | 2003 | J Nephrol2003，16，6： | 1 |
| 12 | The role of axillarylymph node dissection in breast cancer patients with sentinellymph node micrometastases显示文摘 | Gipponi M Canavese G Lionetto R | 2006 | Eur J Surg Oncol2006，32，2： | 1 |
| 13 | Sentinel node biopsycompared with complete axillary dissection for staging early breastcancel with clinically negative lymph nodes : results of randomizedtrial显示文摘 | Canavese G Catturich A Vecchio C | 2009 | Ann 0ncol2009，20，6： | 1 |
| 14 | Cryptorchidism:medicaland surgical treatment in the 1st year of life显示文摘 | Canavese F Cortese M G Magro P | 1998 | Pediatr surg Int1998，14，： | 1 |
| 15 | Incidence of biopsy-proven primary glomerulonephritis in an Italian Province显示文摘 | Piero Stratta Giuseppe P. Segoloni Caterina Canavese Luisa Sandri Gianna Mazzucco Dario Roccatello Marco Manganaro Antonio Vercellone | 1996 | American Journal of Kidney Diseases1996，，5： | 1 |
| 16 | Accuracy of sentinel lymph node biopsy after neo-adjuvant chemotherapy in patients with locally advanced breast cancer and clinically positive axillary nodes显示文摘 | Canavese G Dozin B Vecchio C Tomei D Villa G Carli F | 2011 | Eur J Surg Oncol2011，37，： | 1 |
| 17 | 显示文摘 | Stassi S Canavese G | 2012 | Journal of Polymer Science Part B: Polymer Physics2012，50，14： | 1 |
| 18 | Surgical outcome in patients treated for hemangioma during infancy, childhood, and adolescence: a ret - rospective review of 44 consecutive patients显示文摘 | Canavese F Soo BC Chia SK | 2008 | J Pediatr Orthop2008，28，3： | 1 |
| 19 | The case for oxygen free radicals in the pathogenesis of ischemic acute renal failure显示文摘 | CANAVESE C STRATTA P VERCELLONE A | 1988 | Nephron1988，49，： | 1 |
| 20 | Percutaneous pelvic osteotomy and intertrochanteric varus shortening osteotomy in nonambu- latory GMFCS level IV and V cerebral palsy patients: preliminary report on 30 operated hips显示文摘 | Canavese F Gomez H Kaelin A | 2013 | Pediatr Orthop B2013，22，1： | 1 |
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