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| 1 | Characterization of goat whey proteins and their bioactivity and toxicity assay显示文摘Goat whey is an industry-discarded dairy by-product that has interesting nutritional value and a nutrient composition with important functional potential,where proteins have a high biological value and play an important role in the organism’s physiology.Therefore,the aim of this study was to identify,quantify,concentrate and investigate the capacity of goat whey proteins to perform different biological activities and to evaluate their acute toxicity.Concentrated proteins were quantified and identified by Bradford,Kjehdal and SDS-PAGE methods.Antibacterial activity was performed against Listeria monocytogenes,Salmonella spp.,Staphylococcus aureus,Pseudomonas aeruginosa and Escherichia coli microorganisms and showed MIC ranging from 15 to 120μg mL-1,with the highest inhibition for L.monocytogenes growth.Antiproliferative activity was performed against human malignant melanoma cells and their proliferation inhibition was up to 66.8%within 72 h of exposure.The highest antioxidant capacity was obtained at concentration 2 mg that showed 29.69%of inhibition of DPPH radical oxidation.The acute toxicity test was performed using Artemia franciscana larvae in which whey proteins were able to preserve larval survival throughout exposure.Thus,we can conclude that goat’s whey has proteins that can play a positive effect on health,with antimicrobial activity and without toxicity.The present study highlights the great potential of goat’s whey to be developed as a safe biopreservative or as a functional ingredient in the food industry. | Maria Isabel Ferreira Campos Paula Perazzo de Souza Barbosa Laura Junqueira Camargo Luciano Da Silva Pinto Bianca Mataribu Catarina Serr˜ao Luis Fernando Marques-Santos Jos´e Hon´orio Lopes Julia Mariano Caju de Oliveira Carlos Alberto de Almeida Gadelha Tatiane Santi-Gadelha | 2022 | Food Bioscience2022，46，2： | 2 |
| 2 | Operative Versus Nonoperative Treatment for Stage 0 Distal Rectal Cancer Following Chemoradiation Therapy: Long-term Results显示文摘 | Angelita Habr-Gama Rodrigo Oliva Perez Wladimir Nadalin Jorge Sabbaga Ulysses Ribeiro Afonso Henrique Silva e Sousa Fábio Guilherme Campos Desidério Roberto Kiss Joaquim Gama-Rodrigues | 2004 | Annals of Surgery2004，，4： | 2 |
| 3 | Pathway discovery in mantle cell lymphoma by integrated analysis of high-resolution gene expression and copy number profiling 显示文摘 | Hartmann EM Campo E Wright G | 2010 | Blood2010，116，6： | 1 |
| 4 | Brucella abortus 1NTA2, a novel strain S19 bp26: luc bmp18 double mutant lacking drug resistance markers 显示文摘 | Campos E Cravero S L Delgui L | 2002 | Vet Microbiol2002，87，： | 1 |
| 5 | Prognostic value of CXCR4 and FAK expression in acute myelogenous leukemia显示文摘 | Tavernier-Tardy E Cornillon J Campos L | 2009 | Leuk Res2009，33，6： | 1 |
| 6 | Oculographicfindings in 145 patients with benign paroxysmal positional vertigo显示文摘 | Domenech Campos E Armen Got Carcell ER M Barona DE | 2006 | Acta Otorrinola ringol Esp2006，57，： | 1 |
| 7 | Mantlecell lymphoma 显示文摘 | Campo E Raffeld M Jaffe ES | 1999 | Semin Hematol1999，36，： | 1 |
| 8 | Corticotomy-assisted orthodontics显示文摘 | Cano J Campo J Bonilla E | 2012 | J Clin Exp Dent2012，4，1： | 1 |
| 9 | The effectiveness of grafting to improve salt tolerance in tomato when an 'excluder' genotype is used as scion显示文摘 | Martinez-Rodriguez M M Estan M T Moyano E Garcia- Abellan J O Flores F B Campos J F A1-Azzawi M J Flowers T J Bolarin M C | 2008 | Environmental & Experimental Botany2008，63，1： | 1 |
| 10 | Efficacy assessment oftwo antibiotic prophylaxis regimens in oral and maxillofacialtrauma surgery: preliminary results显示文摘 | Campos G B Lucena E E da Silva J S | 2015 | Int J Clin Exp Med2015，8，2： | 1 |
| 11 | Absence of cyclin D1 protein expression in splenic marginal zone lymphoma显示文摘 | Campo E Mollejo M | 1998 | Mod Pathol1998，11，7： | 1 |
| 12 | Mantle cell lymphoma: presenting features, response to therapy, and prognostic factors 显示文摘 | Bosch F Lopez-Guillermo A Campo E | 1998 | Cancer1998，82，： | 1 |
| 13 | nm23-H1 expression and disease recurrence after surgical resection of small hepatocellular carcinoma显示文摘 | Boix L Bruix J Campo E | 1994 | Gastroenterology1994，107，2： | 1 |
| 14 | Heuristic procedures for the capacitated vehicle routing problem显示文摘 | Campos V Mota E | 2000 | Computational Optimization and Applications2000，16，3： | 1 |
| 15 | Clinical signicance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leakemia cellsat diagnosis显示文摘 | Campos L Guyo D Archimband E | 2010 | Blood2010，79，2： | 1 |
| 16 | On the Evaluation of Unsaturated Flow in a Natural Slope in Rio de Janeiro, Brazil显示文摘 | Gerscovich D M S Vargas Jr E A Campos T M P de | 2006 | Engi- neering Geology2006，88，12： | 1 |
| 17 | New perspective and challenges in the understanding of mantle celllymphoma显示文摘 | Navarro A Campo E | 2011 | Ann Oncol2011，22，4： | 1 |
| 18 | The 2008 WHO classification of lymphoid neoplasms and be- yond:evolving concepts and practical applications显示文摘 | Campo E Swerdlow SH Harris NL | 2011 | Blood2011，117，： | 1 |
| 19 | Evaluating the effects of height-variable reflectivity and antenna sidelobes on the radar equation显示文摘 | Campos E F | 2008 | Journal of Atmospheric and Oceanic Technology2008，25，8： | 1 |
| 20 | Hybrid composites based on polypropylene and carbon fiber and epoxy matrix显示文摘 | Soares B G Campos E A | 2000 | Polym2000，41，10： | 1 |
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